Given the lack of randomized controlled trials on effectiveness compassion-focused therapy in managing shame associated with body dysmorphic disorder and necessity importance this issue, it became essential to investigate psychodynamic individuals disorder. The present study employed a experimental design. statistical population included all women seeking cosmetic surgery who experienced high levels had referred clinics Tehran during fall 2023. research sample consisted 30 participants,...

Impaired cell cycle regulation and disturbance in signal transduction pathway are two major causes of a condition defined as cancer, one the significant reasons for mortality worldwide. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been commonly used anticancer agents, majority this medications possess quinazoline moiety heteroaromatic core. In study, novel series EGFR-TKIs containing quinazolinone core were designed synthesized. Most compounds showed...

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate in hospitalized an ICU a teaching hospital Tehran, Iran. A questionnaire and used collect data. done the affiliated Shaheed Beheshti Medical University. Overall information extracted from 567 prescriptions March 2005 December 2005. extent occurrence frequency potential were categorized...

Nicotine withdrawal precipitates anxiety- and depression-like behaviors associated with disruptions in neurotransmitter systems, alterations glial neurotrophic factors, heightened oxidative stress. This study aimed to investigate the potential therapeutic effects of magnesium sulfate (MgSO₄) on nicotine withdrawal-induced anxiety depression rats as well its implications for regenerative psychiatry. These findings indicated that MgSO₄ administration effectively attenuated induced by rat...

Alzheimer's disease (AD) is a progressive mental disorder that brings huge economic burden to the healthcare systems. During this illness, acetylcholine levels in cholinergic systems gradually diminish, which results severe memory loss and cognitive impairments. Moreover, Butyrylcholinesterase (BuChE) enzyme participates neurotransmission regulation by playing prominent role latter phase of AD. In study, based on donepezil, an effective acetylcholinesterase (AChE) inhibitor, series...

Acetylcholinesterase enzyme (AChE) is the main target in Alzheimer's disease therapy and designing of novel AChE inhibitors a great deal attention.In this study, 2D-QSAR 3D-QSAR models were generated using stepwise multiple linear regressions (SW-MLR) comparative molecular field analysis (CoMFA) respectively.It was found that CoMFA model with r2 0.947 for training set 0.816 test more favorable than which established by SW-MLR method =0.825 r2pred =0.778 2D-QSAR.In addition, obtaining...

Abstract Soluble epoxide hydrolase (sEH), a member of the α/β fold family, catalyzes hydrolysis epoxy eicosatrienoic acids to vicinal diol which are involved in regulation blood pressure and inflammation. In this study, 2D 3D‐QSAR analysis novel N,N′ ‐disubstituted urea derivatives as sEH inhibitors were performed by stepwise multiple linear regressions (SW‐MLR), artificial neural networks (SW‐ANN), Comparative Molecular Field Analysis (CoMFA) comparative molecular similarity index (CoMSIA)....

Infectious agents are considered as a possible cause of schizophrenia. The aim this study was to evaluate the serum levels cytomegalovirus (CMV), Toxoplasma gondii and Brucella antibodies in schizophrenia patients compared with control group.This cross-sectional performed on 75 who were clinically diagnosed using Diagnostic Statistical Manual Mental Disorders (DSM-5) by two independent psychiatrists. As controls, sex age-matched individuals selected from orthopedic surgical wards, admitted...

In this study, a simple and appropriate procedure for the synthesis of functionalized benzothiadiazine 1,1-dioxide with good yields via Cu-catalyzed intramolecular C–H activation reaction from benzenesulfonylchloride N,N′,N′′-trisubstitutedguanidines, generated by copper(II) oxide-catalyzed hydroamination carbodiimides, is reported.

Background: Platelet count is a readily available biomarker predicting disease severity and risk of mortality in the intensive care units (ICU). This study aims to describe frequency, assess factors, evaluate impact thrombocytopenia on patient outcomes Toxicological ICU (TICU).Methods: In this prospective observational Cohort study, we enrolled 184 patients admitted our TICU from October 1st, 2019, August 23rd, 2020. Mild/moderate severe were defined as at least one platelet counts less than...

Introduction: COVID-19 pandemic is not a new issue that encompasses the entire world. It becoming increasingly urgent to find effective medications. This systematic review was conducted discuss clinical impact of some proposed managements against COVID-19. Methods: PubMed, Scopus, Cochrane Library, Embase, and Google Scholar databases were searched from their inception June 15, 2020, identify studies reporting current treatment process medications for COVID-19. Results: After searching...

Introduction: Novel coronavirus disease (Covid-19) has been recognized as a new human infectious caused by mutated type of that might be associated with thrombocytopenia through different mechanisms. Moreover, the presence underlying is risk hospitalization and poor prognosis Covid-19. Case report: Here, we describe 77-year-old male Covid-19 patient essential thrombocythemia. Although gastrointestinal symptoms (GI) were uncommon in early stages pandemic, he presented to clinic GI general...

Background: Sepsis is one of the significant causes mortality in hospitalized patients. This cross-sectional study was performed to determine frequency positive blood culture and assess sepsis criteria based on Third International Consensus Definitions (related Sequential Organ Failure Assessment score) clinical paraclinical findings (i.e., on-admission leukocytosis, increased lactate level, fever) poisoned patients admitted Toxicological Intensive Care Unit (TICU). Methods: Medical records...

Soluble epoxide hydrolase enzyme (sEH) is one of the most promising and emerging targets to develop drugs for multiple disease indications, including hypertension, diabetes, stroke, dyslipidemia, pain, etc. Most inhibitor scaffolds have a urea or amide moiety mimic active-site transition state. In this regard, we developed series sEH inhibitors with pyrimidin-2-ol ring as new secondary pharmacophore, which was subjected in vitro evaluation. Compound 4w...

Introduction: Non- steroidal anti - inflammatory drugs (NSAIDs) are common prescribed medications worldwide for the treatment of inflammatory conditions and pain. However, adverse effects NSAIDs in long term use have led to investigation selective cyclooxygenase - 2 (COX-2) inhibitors with reduced adverse reactions, including gastrointestinal cardiovascular side nephrotoxicity. Methods Results: In this study, a series 2,5-diaryl-1,3,4-oxadiazole derivatives as novel selective COX-2...