A5011661768- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Wnt/β-catenin signaling in development and cancer
- Single-cell and spatial transcriptomics
- Pancreatic function and diabetes
- Congenital heart defects research
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Arsenic contamination and mitigation
- Cancer-related gene regulation
- Plant Stress Responses and Tolerance
- Nerve injury and regeneration
- Photosynthetic Processes and Mechanisms
Dokuz Eylül University
2020-2023
Karlsruhe Institute of Technology
2022-2023
Izmir University
2020-2022
Ege University
2020
Owing to its pronounced regenerative capacity in many tissues and organs, the zebrafish brain represents an ideal platform understand endogenous regeneration mechanisms that restore tissue integrity function upon injury or disease. Although radial glial neuronal cell populations have been characterized with respect specific marker genes, comprehensive transcriptomic profiling of regenerating telencephalon has not conducted so far. Here, by processing lesioned unlesioned hemispheres...
Sox transcription factors are crucial for vertebrate nervous system development. In zebrafish embryo, sox1 genes expressed in neural progenitor cells and neurons of ventral spinal cord. Our recent study revealed that the loss sox1a sox1b function results a significant decline V2 subtype (V2s). Using single-cell RNA sequencing, we analyzed transcriptome lineage progenitors cord at four time points during embryonic development, employing Tg(sox1a:eGFP) line. addition to previously...
Wnt/β-catenin signaling controls many biological processes for the generation and sustainability of proper tissue size, organization function during development homeostasis. Consequently, mutations in Wnt pathway components modulators cause diseases, including genetic disorders cancers. Targeted treatment pathway-associated diseases entails detailed understanding regulatory mechanisms that fine-tune signaling. Here, we identify neurotrophin receptor-associated death domain (Nradd), a homolog...
Abstract The Sox family of transcription factors plays a crucial role in the development vertebrate nervous system. In zebrafish embryo, sox1 genes are expressed neural progenitor cells and neurons ventral spinal cord. We recently reported that loss function sox1a sox1b leads to significant decline subtype V2 neurons, called V2s, zebrafish. Here, single-cell RNA sequencing approach was used analyse transcriptome lineage progenitors cord at four different time points during first five days...
The Sox family of transcription factors plays a crucial role in the development vertebrate nervous system. In zebrafish embryo, sox1 genes are expressed neural progenitor cells and neurons ventral spinal cord. We recently reported that loss function sox1a sox1b leads to significant decline subtype V2 neurons, called V2s, zebrafish. Here, single-cell RNA sequencing approach was used analyse transcriptome lineage progenitors cord at four different time points during first five days embryonic...
Abstract Non-alcoholic fatty liver disease (NAFLD) includes a range of conditions ranging from excess fat accumulation to failure. NAFLD is strongly associated with high-fat diet (HFD) consumption that constitutes metabolic risk factor. While HFD has been elucidated concerning its several systemic effects, there little information about influence on the brain at molecular level. Here, by using (HFD)-feeding adult zebrafish, we first reveal uptake results in weight gain and liver. Prolonged...