A5012778985- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Forensic Toxicology and Drug Analysis
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Prenatal Substance Exposure Effects
- Genomics, phytochemicals, and oxidative stress
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Diagnosis and Treatment of Venous Diseases
- Birth, Development, and Health
- Muscle and Compartmental Disorders
- Venous Thromboembolism Diagnosis and Management
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Signaling Pathways in Disease
Indiana University
2024
Indiana University Bloomington
2021-2024
The University of Texas at San Antonio
2016-2019
Neurosciences Institute
2016-2019
University of Castilla-La Mancha
2011-2013
Institute of Clinical and Experimental Medicine
1977
Abstract Oxidative stress that correlates with damage to nigrostriatal dopaminergic neurons and reactive gliosis in the basal ganglia is a hallmark of methamphetamine (METH) toxicity. In this study, we analyzed protective role transcription factor Nrf2 (nuclear factor‐erythroid 2‐related 2), master regulator redox homeostasis, METH‐induced neurotoxicity. We found deficiency exacerbated dopamine neurons, shown by an increase loss tyrosine hydroxylase (TH)‐ transporter (DAT)‐containing fibers...
Abstract Glutamate signalling through the N ‐methyl‐ d ‐aspartate receptor (NMDAR) activates enzyme neuronal nitric oxide synthase (nNOS) to produce molecule (NO). We hypothesized that disruption of protein–protein interaction between nNOS and scaffolding protein postsynaptic density 95 kDa (PSD95) would block NMDAR‐dependent NO represent a viable therapeutic route decrease opioid reward relapse‐like behaviour without unwanted side effects NMDAR antagonists. used conditioned place preference...
The endocannabinoid system interacts with the reward to modulate responsiveness natural reinforcers, as well drugs of abuse. Previous preclinical studies suggested that direct blockade CB1 cannabinoid receptors (CB1R) could be leveraged a potential pharmacological approach treat substance use disorder, but this strategy failed during clinical trials due severe psychiatric side effects. Alternative strategies have emerged circumvent effects binding through development allosteric modulators....
Abstract The endocannabinoid system interacts with the reward to modulate responsiveness natural reinforcers, as well drugs of abuse. Previous preclinical studies suggested that direct blockade CB1 cannabinoid receptors (CB1R) could be leveraged a potential pharmacological approach treat substance use disorder, but this strategy failed during clinical trials due severe psychiatric side effects. Alternative strategies have emerged circumvent effects binding through development allosteric...
The costs associated with obtaining illicit drugs can fluctuate depending upon the relative drug availability. As a consequence of changing costs, effort that one must exert to obtain is dynamic. Considerable evidence illustrates critical role for dopamine in ventral medial striatum mediating reinforcement. However, little known regarding how release affected by changes earning drugs. We used fast-scan cyclic voltammetry determine operant requirement self-administered cocaine male rats....
Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) an intravenous drug self-administration paradigm to investigate the impact state on morphine-seeking behavior in extinction (i.e. when morphine is withheld). SNI, sham-operated naive groups exhibited similar levels active lever presses for infusions fixed ratio 1 (FR1) schedule. Self-administration morphine, but not vehicle, attenuated...
Abstract Stress affects dopamine‐dependent behaviors in part through the actions of corticotropin releasing factor (CRF) ventral tegmental area (VTA). For example, acute stress engages CRF signaling VTA to suppress motivation work for food rewards. In contrast, promotes drug‐seeking behavior VTA. These diverging behavioral effects food‐ and drug‐based tasks could indicate that modulates goal‐directed a reinforcer‐specific manner. Alternatively, prior drug experience functionally alter how...
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement transmission represents a potential analgesic strategy. However, therapeutic current GABA agonists and modulators limited by unwanted side effects. We postulated that GABA’s degradation enzyme, aminotransferase (GABA-AT), would increase endogenous levels produce analgesia. evaluated antinociceptive efficacy the potent GABA-AT inhibitor OV329 in rodent models neuropathic inflammatory pain...
Abstract Stress affects dopamine-dependent behaviors in part through the actions of corticotropin releasing factor (CRF) ventral tegmental area (VTA). For example, acute stress engages CRF signaling VTA to suppress motivation work for food rewards and promote drug seeking behavior. These diverging behavioral effects food- drug-based tasks could indicate that modulates goal-directed a reinforcer-specific manner. Alternatively, prior experience functionally alter how regulates To address these...