A5030673388- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Cholinesterase and Neurodegenerative Diseases
- Mosquito-borne diseases and control
- Vector-Borne Animal Diseases
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Insect Resistance and Genetics
- Pesticide Exposure and Toxicity
- Dengue and Mosquito Control Research
- Bipolar Disorder and Treatment
- Nicotinic Acetylcholine Receptors Study
- Hip and Femur Fractures
- Neurotransmitter Receptor Influence on Behavior
- Malaria Research and Control
- Bone health and osteoporosis research
- Chemical synthesis and alkaloids
- Dementia and Cognitive Impairment Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Enzyme function and inhibition
- Neuroinflammation and Neurodegeneration Mechanisms
- Zoonotic diseases and public health
- Insect symbiosis and bacterial influences
Umeå University
1999-2023
Swedish Defence Research Agency
2009-2022
Swedish University of Agricultural Sciences
2022
University of Kelaniya
2022
Swedish Society for Nature Conservation
2022
National Environment Agency
2008-2009
Singapore General Hospital
2009
Ministry of Health
2009
University of California, San Diego
2005
University Hospital of Umeå
1980-1995
The aims of this study were to estimate the incidence acute confusional state (ACS), its predisposing factors and consequences in 111 consecutive patients operated for fractured neck femur. ACS was 61 percent predicting old age dementia. Drugs with anticholinergic effect, depression, previous stroke that seemed be associated development ACS. Ninety-two who had severe perioperative blood pressure drops developed prolonged ward-stay at orthopedic department, a greater need long-term care after...
BERGGREN, D.; GUSTAFSON, Y.; ERIKSSON, B.; BUCHT, G.; HANSSON, L. -I.; REIZ, S.; WINBLAD, B. Author Information
The authors have investigated whether treatment of sleep apnoea with nasal continuous positive airway pressure (nCPAP) improves depressive symptoms, personal activities daily living (ADL), cognitive functioning and delirium in patients that suffered a stroke. Sixty-three consecutively admitted to stroke rehabilitation unit 2-4 weeks after stroke, an apnoea/hypopnoea index > or =15, were randomized either nCPAP (n=33) control group (n=30). Four dropped out randomization. Both groups assessed...
A procedure for improving the specificity of enzyme-linked immunosorbent assays (ELISA) was devised, based on addition antigen-specific or non-immune immunoglobulins to citrated plasma sample and defining difference in assay response between these two mixtures as part response. When applied measurement tissue plasminogen activator (t-PA; EC 3.4.21.31) antigen plasma, this resulted elimination overestimates obtained a large proportion (10-20%) patients' samples when assayed according...
Chikungunya fever swept across many South and South-east Asian countries, following extensive outbreaks in the Indian Ocean Islands 2005. However, molecular epidemiological data to explain recent spread evolution of virus (CHIKV) region are still limited. This study describes genetic Characteristics evolutionary relationships CHIKV strains that emerged Sri Lanka Singapore during 2006–2008. The viruses isolated also included those imported from Maldives (n=1), India (n=2) Malaysia (n=31). All...
Rift Valley fever virus is an emerging mosquito-borne that causes infections in animals and human beings Africa the Arabian Peninsula. Outbreaks of lead to mass abortions livestock, but such have not been identified beings. Our aim was investigate cause miscarriages febrile pregnant women area endemic for fever.Pregnant with unknown origin who attended governmental hospital Port Sudan, between June 30, 2011, Nov 17, 2012, were sampled at admission included this cross-sectional study. Medical...
Abstract Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore January 2008. After 3 months absence, locally acquired Chikungunya cases resurfaced May 2008, causing an outbreak that resulted total 231 by September The circulating viruses were related to East, Central, and South African genotypes emerged the Indian Ocean region 2005. local due wild-type virus (alanine at codon 226 envelope 1 gene) occurred area where Aedes aegypti...
Emerging mosquito-borne viruses continue to cause serious health problems and economic burden among billions of people living in near the tropical belt world. The highly invasive mosquito species Aedes aegypti albopictus have successively invaded expanded their presence as key vectors Chikungunya virus, dengue yellow fever Zika that has consecutively led frequent outbreaks corresponding viral diseases. Of note, these two gradually adapted changing weather environmental conditions leading a...
ABSTRACT Puumala virus (PUUV) is the endemic hantavirus in northern Sweden and causes nephropathia epidemica (NE), a milder form of hemorrhagic fever with renal syndrome. There need for fast reliable diagnostics to differentiate disease from other infections. By aligning RNA sequences isolated 11 different bank voles one human patient, we designed real-time reverse transcriptase (RT) PCR method detection PUUV RNA. The RT-PCR assay showed linearity 20 2 × 10 6 copies correlation coefficient...
Abstract Background Affecting both livestock and humans, Rift Valley Fever is considered as one of the most important viral zoonoses in Africa. However, no licensed vaccines or effective treatments are yet available for human use. Naked DNA an interesting approach since virus highly infectious existing attenuated vaccine strains display adverse effects animal trials. In this study, gene-gun immunisations with cDNA encoding structural proteins were evaluated mice. The induced immune responses...
There is a need for improved screening methods spatial neglect.To construct VR-test battery and evaluate its accuracy usability in patients with acute stroke.VR-DiSTRO consists of standard desktop computer, CRT monitor eye shutter stereoscopic glasses, force feedback interface, software, developed to create an interactive immersive 3D experience. VR-tests were validated the conventional Star Cancellation test, Line bisection, Baking Tray Task (BTT), Visual Extinction test. A validation The...
The brains from 12 schizophrenic patients were investigated postmortem for their content of noradrenaline (NA), dopamine (DA), 5‐hydroxytryptamine (5‐HT), homovanillic acid (HVA), and 5‐hydroxyindolacetic (5‐HIAA). Six the schizophrenics had been lobotomized 25–30 years prior to death. A control group matched age was collected in autopsy room. concentrations NA, DA, HVA different parts brain did not differ those controls. 5‐HT determined 11 nuclei or areas brain. lower mean values compared...
Abstract Background Hantaviruses cause human disease in endemic regions around the world. Outbreaks of hantaviral diseases have been associated with changes rodent population density and adaptation to settlements leading their proliferation close proximity dwellings. In a parallel study initiated determine prevalence pathogens Singapore's wild population, 1206 rodents were trapped screened. The findings established hantavirus seroprevalence 34%. This paper describes molecular...
Abstract Mosquito‐borne infectious diseases are emerging in many regions of the world. Consequently, surveillance mosquitoes and concomitant agents is great importance for prediction prevention mosquito‐borne diseases. Currently, morphological identification traditional procedure. However, sequencing specified genes or standard genomic regions, DNA barcoding, has recently been suggested as a global classification different species. Our aim was to develop genetic method identify study their...
Introduction: Mosquito-borne viruses have a widespread distribution across the globe and are known to pose serious threats human animal health. The maintenance dissemination of these in nature driven through horizontal vertical transmission. In temperate climate northern Sweden, there is dearth knowledge on whether mosquito-borne that occur transmitted transovarially. To gain better understanding virus circulation maintenance, mosquito larvae were sampled Sweden during first second year...
ABSTRACT– Eighteen patients with the clinical diagnosis dementia of Alzheimer type (AD/SDAT) and 20 multiinfarct (MID) were interviewed using a subscale to Comprehensive Psychopathological Rating Scale (CPRS), consisting items measuring psychopathological symptoms signs commonly seen in dementia. The aim investigation was evaluate whether difference psychopathology between AD/SDAT MID could be observed during semistructured psychiatric interview CPRS. In both groups duration illness similar...
Predicting risk of zoonotic diseases, i.e., diseases shared by humans and animals, is often complicated the population ecology wildlife host(s). We here demonstrate how ecological knowledge a disease system can be used for early prediction human using Puumala hantavirus (PUUV) in bank voles (Myodes glareolus), which causes Nephropathia epidemica (NE) humans, as model system. Bank vole populations at northern latitudes exhibit multiannual fluctuations density spatial distribution, phenomenon...