About
Contact & Profiles
A5025868255
Research Areas
- Fibroblast Growth Factor Research
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
Technion – Israel Institute of Technology
2022
Heparan sulfate proteoglycans (HSPGs) mediate essential interactions throughout the extracellular matrix (ECM), providing signals that regulate cellular growth and development. Altered HSPG composition during tumorigenesis strongly aids cancer progression. Heparanase (HPSE) is principal enzyme responsible for heparan catabolism markedly up-regulated in aggressive cancers. HPSE overactivity degrades HSPGs within ECM, facilitating metastatic dissemination releasing mitogens drive...
10.1073/pnas.2203167119
article
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Proceedings of the National Academy of Sciences
2022-07-26
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