A5072168735- Pancreatic function and diabetes
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Cannabis and Cannabinoid Research
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Hearing, Cochlea, Tinnitus, Genetics
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Diabetes and associated disorders
- Hydrogels: synthesis, properties, applications
- Diabetes Management and Research
- Lipid Membrane Structure and Behavior
- Diet and metabolism studies
- Advanced biosensing and bioanalysis techniques
- Retinal Diseases and Treatments
- Molecular Sensors and Ion Detection
- Steroid Chemistry and Biochemistry
- Adenosine and Purinergic Signaling
- Pediatric Hepatobiliary Diseases and Treatments
- Conducting polymers and applications
- Aldose Reductase and Taurine
- Electron Spin Resonance Studies
- Supramolecular Self-Assembly in Materials
Curtin University
2020-2025
Carol Davila University of Medicine and Pharmacy
2024-2025
Clinical Emergency Hospital Bucharest
2024-2025
Ear Science Institute Australia
2021-2023
Queen Elizabeth II Medical Centre
2021-2023
Babeș-Bolyai University
2019-2020
Interdisciplinary Centre for Comparative Research Foundation
2008
University of Toronto
2008
Hai phong University Of Medicine and Pharmacy
2008
Iuliu Hațieganu University of Medicine and Pharmacy
2005-2006
Bile acids have recently been studied for potential applications as formulation excipients and enhancers drug release; however, some bile are not suitable this application. Unconjugated lithocholic acid (ULCA) has shown formulation-stabilizing anti-inflammatory effects. Lipophilic drugs poor gut absorption after an oral dose, which necessitates the administration of high doses causes subsequent side Probucol (PB) is a highly lipophilic with that resulted in restrictions on its clinical...
Background: Necrobiosis lipoidica (NL) is a rare granulomatous skin disorder with predilection for females, often associated diabetes mellitus (DM). This paper aims to comprehensively review the literature on NL, focusing its association DM, thyroid disorders, and metabolic syndrome. Methods: A systematic search was conducted in English-language from inception October 2023, utilizing PubMed. We identified 530 studies selected 19 based clinical significance, statistical support, relevance...
Abstract Inner ear delivery requires safe and effective drug vehicles incorporating high‐viscosity formulations with permeation enhancers. This study designs novel thermoresponsive‐smart polymer‐bile acid cyclodextrin‐based nanogels for inner delivery. Nanogels are examined their rheological physical properties. The biocompatibility studies will be assessed on auditory macrophage cell lines by investigating the impact of cellular viability, mitochondrial respiration, glycolysis,...
Background/Objectives: Chronic wounds, including hidradenitis suppurativa (HS) and venous ulcers (VU), are commonly associated with complex microbial communities that may influence wound healing treatment outcomes. Understanding diversity antibiotic resistance patterns is essential in order to optimize therapeutic strategies. This study aimed investigate the populations profiles HS VU patients, comparing prevalence of common pathogens their antimicrobial profiles. Methods: We conducted a...
Recent studies in our laboratories have shown promising effects of bile acids ➀ drug encapsulation for oral targeted delivery (via capsule stabilization) particularly when encapsulated with Eudragit NM30D® and ➁ viable-cell supporting cell viability biological activities, postencapsulation). Accordingly, this study aimed to investigate applications acid-Eudragit capsules ready delivery. Mouse-cloned pancreatic β-cell line was cultured cells using capsules, capsules’ images, viability,...
Background: Sensorineural hearing loss has been associated with oxidative stress. However, an antioxidant that passes effectively through the ear remains elusive. Method: Probucol (PB)-based nanoparticles were formed using a spray-drying encapsulation technique, characterized and tested in vitro. Results: Uniform, spherical produced. The addition of lithocholic acid to PB formulations did not affect drug content or production yield, but it modify capsule size, surface tension, electrokinetic...
Abstract Hearing loss is a widespread condition, affecting people from range of demographics. Gene therapy an emerging method for the amelioration this condition. Challenges associated with delivery genes to various sites within ear remain significant challenge. In present work, novel polymer nanoparticle system was developed, incorporating bile acid excipient. Bile acids have previously been shown improve drug through their permeation enhancing properties; however, few studies report use in...
Probucol (PB) is a highly lipophilic drug with potential protective effects on pancreatic β-cells from inflammation and oxidation. PB has poor bioavailability solubility, despite many attempts, significant improvement in antidiabetic or absorption yet to be discovered. Recently, the role of bile acids been established formulation stabilisation as cell-penetrating agents. Promising results pharmaceutical studies stability release patterns when lithocholic acid (LCA) conjugated sodium alginate...
The pathophysiology of a multitude diseases is influenced by bioenergetic dysfunction. Healthy mitochondria are presented as essential for the regulation and function multiple cell types, including cells relevance this research: pancreatic beta cells, muscle liver cells. Hence, effects hydrogels (particularly nanogels) on bioenergetics needs to be taken into account when designing optimum delivery matrices. Several polymers have been suggested use in nanogels, with focus chitosan due its...
Introduction: Recent studies in our laboratory have shown that some bile acids, such as chenodeoxycholic acid (CDCA), can exert cellular protective effects when encapsulated with viable β-cells via anti-inflammatory and anti-oxidative stress mechanisms. However, to explore their full potential, formulating acids (that are intrinsically lipophilic) be challenging, particularly if larger doses required for optimal pharmacological effects. One promising approach is the development of nano gels....
Aim: Excessive free radicals contribute to oxidative stress and mitochondrial dysfunction in sensorineural hearing loss (SNHL). The antioxidant probucol holds promise, but its limited bioavailability inner ear barriers hinder effective SNHL treatment. Methodology: We addressed this by developing probucol-loaded nanoparticles with polymers lithocholic acid tested them on House Ear Institute-Organ of Corti cells. Results: Probucol-based effectively reduced stress-induced apoptosis, enhanced...
In a recent study, in our laboratory, primary unconjugated bile acids, commonly found humans, chenodeoxycholic acid (CDCA), have been shown to improve stability of nanoencapsulated lipophilic drugs and their release profile after oral administration likely via electrokinetic stabilisation. Hence, this study aimed examine the effects CDCA on exerting similar hydrophilic drugs.Various CDCA-based formulations were produced for orally administered drug, metformin. Analyses these included...
Background: Hearing loss is a condition that may affect wide array of patients from various backgrounds. There are no cures for sensorineural hearing loss. Gene therapy one possible method improving status; however, gene delivery remains challenging. Materials & methods: Polymer nanoaggregates alginate and poly-L-lysine were prepared with without bile acid. The had physical properties, cytotoxicity, release expression analyzed. Results discussion: nanoparticles produced appropriate size...
The aim of this study is to test the biocompatibility hydrogels with polysaccharides and bile acids on three murine cell lines.