A5028419873- Circadian rhythm and melatonin
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Human Health and Disease
- Biochemical Acid Research Studies
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Photoreceptor and optogenetics research
- Spaceflight effects on biology
- Diet, Metabolism, and Disease
- Antioxidant Activity and Oxidative Stress
- Lipoproteins and Cardiovascular Health
- Psychological and Temporal Perspectives Research
- Neuroscience of respiration and sleep
- Plant-based Medicinal Research
- Chemical and Physical Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Synthesis and Characterization of Heterocyclic Compounds
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Free Radicals and Antioxidants
Bukovinian State Medical University
2017-2024
Ukrainian Medical Stomatological Academy
2018
Proteins can be key biochemical markers for evaluating the functional activity of nervous system cells. They are involved in proliferation and differentiation nerve glial cells arrangement many metabolic functions brain. This study aimed to analyze concentration proteins neurons lateral preoptic nucleus (LPON) hypothalamus mature old rats under standard altered lighting conditions. Our results show that was significantly higher than (0.274±0.0017 optical density units), with a predominance...
Aim: To find out the influence of melatonin on enzyme activities glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in liver rats with alloxan diabetes under conditions variable photoperiod. Materials Methods: Experiments were conducted male outbred white weighing 180}10 mg. Photoperiodic changes: 1) equinox (light from 8:00 a.m. to p.m., 500 lux); 2) light throughout day night (500 3) darkness. Alloxan was induced by administration a 5% solution...
The effect of constant illumination as a stress factor on the state "early response" c-fos gene in lateral magnocellular subnuclei paraventricular nucleus (lmPVN) hypothalamus rats at different time intervals (day and night) has been studied. To identify c-Fos histological sections hypothalamus, secondary (indirect) immunofluorescence method is used. Expression product this gene, protein, animals kept under normal conditions alternation darkness, shows clear-cut circadian character. There...
The aim: To find out density of melatonin receptors 1A in the neurons lateral preoptic nucleus hypothalamus mature and old rats under various light conditions. Materials methods: study was carried on 72 albino with conditions appropriate for experiment. circadian differences material taken at 2 p.m. a.m. Visualization primary antibodies against (Abcam) conducted by means polymeric system Dako diaminobenzidine staining microscope Delta Optical Evolution 100. intensity assessed digital copies...
Ultramicroscopic organization of neurosecretory cells supraoptic nuclei the anterior hypothalamus rats has been examined. Under standard light regimen (12.00C:12.00T) ultrastructure neurons is indicative decrease their functional activity during period day, and increase – dark day. Light stress (24.00C:00T) results in considerable desynchronosis causes destructive changes components examined structures which become more pronounced at 2 a.m. due to inhibition pineal gland activity.
The aim: To determine the influence of melatonin on glucose level and content malondialdehyde, activities pyruvate kinase glucose-6-phosphate dehydrogenase enzymes in blood; histochemical features glycogen distribution liver rats with impaired tolerance. Materials methods: Diabetes was induced by intra-abdominal injection a 5% solution alloxan monohydrate at rate 170 mg/kg body weight. Four days after animals were divided into tolerance melatonin-group (5 mg/ kg «Sigma» USA, daily...
L'analyse du profil lipidique des femmes enceintes avec de l'obésité selon le statut allélique gènes l'enzyme conversion l'angiotensine (ECA I/D) et l'inhibiteur d'activation plasminogène 1 (RA-1 4G/5G)Les modifications survenues dans ou sans obésité ont été étudiées polymorphisme I / D gène (ECA) génique 4G5Gde l' inhibiteur type (RAI-1).La combinaison entre
Introduction. Melatonin production is considerably suppressed by light and affects the ability to transfer daily rhythm information from hypothalamus other neural target sites thus alters expression of some biological rhythms. The hormone controls state hypothalamic-pituitary system endocrine gland activity through melatonin receptors (membrane, cytosolic nuclear ones). In addition, using a mechanism feedback, it interferes with supraoptic nucleus hypothalamus, which regulates water-salt...
A progressive increase of complications type 2 DM makes the problem very important for clinical andfundamental medicine. In particular, neurodegenerative processes in case aggravate courseof disease, change a usual life rhythm, and are valuable cause high rates disability lethality.Deterioration cognitive functions is one main diabetes. certain literary sourcesinhibitors angiotensin-transforming enzyme considered as means to prevent treat complicationsof diabetes mellitus. Their role...
The aim: Was to study enalapril effect on protein peroxide oxidation and lipids of the cerebral cortex hippocampus rats with neurodegeneration pattern. Materials methods: experiments were conducted nonlinear albino male 0,18-0,20 kg body weight. Modeled was simulated by intraperitoneal introduction scopolamine hydrochloride during 27 days in dose 1 mg/kg. Enalapril introduced Results: In modeled scopolamine-induced under effect, content products, reacting 2-thiobarbituric acid proteins a...
Light information that is perceived by the retinal photoreceptors transmitted along retinohypothalamic pathway (the ganglion cells present in it) and supraoptic fibers, suprachiasmatic, paraventricular, arcuate nuclei of hypothalamus, through trunk upper thoracic region lateral intermedial spinal cord, sym- pathic neurons superior cervical pineal gland. In dark, signals from suprachiasmatic nucleus enhance synthesis release norepinephrine sympathetic endings. The experiments were carried out...
The article presents analysis of the results original histochemical studies tigroid substance neurons lateral preoptic nucleus hypothalamus in mature and old rats under influence different light modes. In all observations, was located cytoplasm form individual granular formations sizes shapes. amount is greater than older rats. At same time, it should be noted that experimental conditions significantly affected particular, deprivation, optical density specific staining for increased...
We studied the morphologic and histochemical organization of neurons hypothalamic supraoptic nucleus in rats exposed to different durations photoperiod injection melatonin. Morphometric analyses were performed after staining brain histological sections for RNA. Prolonged illumination leads more pronounced changes parameters structures at 2 a.m. than p.m., particularly decreasing concentration RNA cell nuclei. The use exogenous melatonin does not normalize revealed hypothalamus caused by...