A5046344801- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- Computational Drug Discovery Methods
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Cultural Identity and Representation
- Oral Health Pathology and Treatment
- Peptidase Inhibition and Analysis
- HIV/AIDS oral health manifestations
- Themes in Literature Analysis
- Cancer Treatment and Pharmacology
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- RNA Research and Splicing
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- Drug Transport and Resistance Mechanisms
- Comics and Graphic Narratives
University of Louisville
2022-2025
Pfizer (United States)
2011-2016
The University of Texas MD Anderson Cancer Center
2011
Abstract HER-2 belongs to the ErbB family of receptor tyrosine kinases, which has been implicated in a variety cancers. Overexpression is seen 25–30% breast cancer patients and predicts poor outcome with primary disease. Trastuzumab (Herceptin), monoclonal antibody HER-2, specifically approved for HER-2-positive but active only subset these tumors. Blocking function by small molecule kinase inhibitor, therefore, represents an attractive alternate strategy inhibit growth HKI-272 potent...
Poorly differentiated tumors in non-small cell lung cancer (NSCLC) have been associated with shorter patient survival and time to recurrence following treatment. Here, we integrate multiple experimental models clinicopathologic analysis of delineate a cellular hierarchy NSCLC. We show that the oncofetal protein 5T4 is expressed on tumor-initiating cells worse clinical outcome Coexpression factors involved epithelial-to-mesenchymal transition were observed undifferentiated but not tumor...
Abstract Purpose: Because resistance to paclitaxel and docetaxel is frequently observed in the clinic, new anti-microtubule agents have been sought. The aim of this study was evaluate efficacy oral activity a novel taxane (MST-997) paclitaxel- docetaxel-resistant tumor models vitro vivo. Experimental Design: Tubulin polymerization assays, immunohistochemistry, cell cycle analysis used mechanism action MST-997. effect MST-997 on growth inhibition panel lines that overexpressed P-glycoprotein...
Intratumoral heterogeneity in non-small cell lung cancer (NSCLC) has been appreciated at the histological and cellular levels, but association of less differentiated pathology with poor clinical outcome is not understood molecular level. Gene expression profiling intact human tumors fails to reveal nature functionally distinct epithelial subpopulations, particular tumor cells that fuel growth, metastasis, disease relapse. We generated primary serum-free cultures NSCLC then exposed them...
Abstract Poorly differentiated tumors in non-small cell lung cancer (NSCLC) are refractory to chemotherapy and associated with short survival time. Here we integrate multiple experimental models clinicopathological analysis of patient delineate a cellular hierarchy NSCLC. We demonstrate that the oncofetal protein 5T4 is expressed on tumor-initiating cells worse clinical outcome Coexpression factors involved epithelial-to-mesenchymal transition was observed undifferentiated but not tumor...
Supplementary Figures 1-6, Tables 1-5, Methods from Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells
Supplementary Figures 1-6, Tables 1-5, Methods from Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells
<div>Abstract<p>Poorly differentiated tumors in non–small cell lung cancer (NSCLC) have been associated with shorter patient survival and time to recurrence following treatment. Here, we integrate multiple experimental models clinicopathologic analysis of delineate a cellular hierarchy NSCLC. We show that the oncofetal protein 5T4 is expressed on tumor-initiating cells worse clinical outcome Coexpression factors involved epithelial-to-mesenchymal transition were observed...
<div>Abstract<p>Poorly differentiated tumors in non–small cell lung cancer (NSCLC) have been associated with shorter patient survival and time to recurrence following treatment. Here, we integrate multiple experimental models clinicopathologic analysis of delineate a cellular hierarchy NSCLC. We show that the oncofetal protein 5T4 is expressed on tumor-initiating cells worse clinical outcome Coexpression factors involved epithelial-to-mesenchymal transition were observed...
This pilot project was implemented to minimize barriers in access care, reduce the risk for oral health and systemic diabetes complications, optimize outcomes patients with seeking comprehensive dental treatment.The intervention group included who participated hemoglobin A1c (HbA1c) testing during their initial screening appointment. The participants whose HbA1c value ≤ 9.0% were expedited into scheduling queue next examination Health literacy assessed regarding patients' understanding of...