A5040226697- Tendon Structure and Treatment
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- Bee Products Chemical Analysis
- Elasticity and Material Modeling
- Veterinary Equine Medical Research
- Exercise and Physiological Responses
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Collagen: Extraction and Characterization
- 3D Printing in Biomedical Research
- Connective tissue disorders research
- Heat shock proteins research
- Muscle activation and electromyography studies
- Electrospun Nanofibers in Biomedical Applications
- Adhesion, Friction, and Surface Interactions
- Lower Extremity Biomechanics and Pathologies
- Gear and Bearing Dynamics Analysis
- Genetic and Kidney Cyst Diseases
- Laser Applications in Dentistry and Medicine
- Knee injuries and reconstruction techniques
- Surface Treatment and Residual Stress
- Gene expression and cancer classification
Queen Mary University of London
2016-2025
University of Liverpool
2018
University of East Anglia
2012
Norwich Research Park
2012
During physiological loading, a tendon is subjected to tensile strains in the region of up 6 per cent. These are reportedly transmitted cells, potentially initiating specific mechanotransduction pathways. The present study examines local strain fields within fascicles order determine mechanisms responsible for fascicle extension. A hierarchical approach analysis was adopted, involving micro and macro examination. Micro examination carried out using custom-designed rig, enable tissue isolated...
Tendons transfer force from muscle to bone. Specific tendons, including the equine superficial digital flexor tendon (SDFT), also store and return energy. For efficient function, energy-storing tendons need be more extensible than positional such as common extensor (CDET), when tested in vitro have a lower modulus failure stress, but higher strain. It is not known how differences matrix organization contribute distinct mechanical properties functionally different tendons. We investigated of...
Age-related tendinopathy is common in both humans and horses; the initiation progression of which similar between species. The majority tendon injuries occur to high-strain energy storing tendons, such as human Achilles equine superficial digital flexor (SDFT). By contrast, low-strain positional anterior tibialis extensor (CDET) are rarely injured. It has previously been established that greater extension occurs at fascicular interface SDFT than CDET; this may facilitate large strains...
While the predominant function of all tendons is to transfer force from muscle bone and position limbs, some additionally as energy stores, reducing cost locomotion. Energy storing experience extremely high strains need be able recoil efficiently for maximum storage return. In equine forelimb, superficial digital flexor tendon (SDFT) has much higher failure than positional common extensor (CDET). However, we have previously shown that this not due differences in properties SDFT CDET...
Objectives. Histological examination of pathological tendon generally does not reveal signs inflammation. However, the inflammatory cytokine IL-6 has been shown to be expressed in ruptured rotator cuff tendon. The aim this study was investigate expression family members painful posterior tibialis (PTT) and Achilles (AT) compared with normal
ABSTRACT The role of inflammation in tendon injury is uncertain and a topic current interest. In vitro studies accelerated overload damage can serve as valuable source information on the early stages tendinopathy. Viable fascicle bundles from bovine flexor tendons were subjected to cyclic uniaxial loading 1–10% strain. Immuno‐staining for inflammatory markers matrix degradation was performed samples after mechanical testing. Loaded exhibited visible extracellular damage, with disrupted...
Extracorporeal shock wave therapy (ESWT) is a noninvasive treatment for chronic tendinopathies, however little known about the in-vivo biological mechanisms of ESWT.Using microdialysis, we examined real-time response healthy and pathological tendons to ESWT.A single session ESWT was administered mid-portion Achilles tendon in thirteen individuals (aged 25.7 ± 7.0 years) patellar or six patients with tendinopathies 39.0 14.9 years).Dialysate samples from surrounding peri-tendon were collected...
Abstract Tendon is a simple aligned fibre composite, consisting of collagen-rich fascicles surrounded by softer interfascicular matrix (IFM). The composition and interactions between these material phases are fundamental in ensuring tissue mechanics meet functional requirements. However the IFM poorly defined, therefore tendon structure-function relationships incompletely understood. We hypothesised that has more complex proteome, with faster turnover than fascicular (FM). Using...
Repetitive strain or ‘overuse’ is thought to be a major factor contributing the development of tendinopathy. The aims our study were develop novel cyclic loading system, and use it investigate effect defined conditions on mechanical properties gene expression isolated tendon fascicles. Tendon fascicles dissected from bovine‐foot extensors subjected tensile (1 Hz ) at 30% 60% failure, for 0 h (control), 15 min, 30 1 h, 5 h. Post loading, quasi‐static test failure assessed damage. Gene...
Abstract Although the predominant function of all tendons is to transfer force from muscle bone and position limbs, some additionally as energy stores, reducing energetic cost locomotion. To maximise storage return, energy‐storing need be more extensible elastic than with a purely positional function. These properties are conferred in part by specialisation specific compartment tendon, interfascicular matrix, which enables sliding recoil between adjacent fascicles. However, composition...
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided specialisation IFM to enable repeated sliding recoil. With ageing, becomes stiffer less fatigue resistant, potentially explaining why older become injury-prone. Recent data indicates enrichment elastin within IFM, but this has yet be quantified. We hypothesised that prevalent in energy tendons, mainly localised...
As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that attracting interest from both basic and translational scientists. The Biochemical Society, with its mission supporting advancement science, addressing grand challenges have societal impact, has included OoC into their agenda to review current state art, bottlenecks future directions. This conference brought together representatives main stakeholders in field including academics, end-users, regulators...