A5078936950- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Cardiac Arrest and Resuscitation
- Electrolyte and hormonal disorders
- Liver Disease and Transplantation
- Sepsis Diagnosis and Treatment
- Renal and related cancers
- Trauma and Emergency Care Studies
- Genomics and Rare Diseases
- Autopsy Techniques and Outcomes
- Medical and Health Sciences Research
- Renal Transplantation Outcomes and Treatments
- BRCA gene mutations in cancer
Groene Hart Ziekenhuis
2024
Erasmus MC
2012-2019
Erasmus University Rotterdam
2012-2017
In Brief Background Although chronic deterioration in renal function is frequently seen after cardiac transplantation, which partly explained by the use of calcineurin inhibitors, data on consequences acute kidney injury (AKI) transplantation are scarce. current study, incidence AKI and its impact mortality was evaluated. Methods Five hundred thirty-one transplant recipients (age ≥18 years) were evaluated for postoperative defined Kidney Disease Improving Global Outcome criteria. Secondary...
Critically ill patients with AKI necessitating renal replacement therapy (RRT) have high in-hospital mortality, and survivors are at risk for kidney dysfunction hospital discharge. The objective was to evaluate the association between impaired function discharge long-term overall survival.Degree of in relation effects on survival patient mortality investigated a retrospective cohort study 1220 adults admitted an intensive care unit who received continuous RRT 1994 2010.After discharge,...
The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part heterogeneous performance these markers that has been reported literature. We studied influence timing values proteins, measured before rise serum creatinine (SCr) critically ill, non-septic patients. Seven hundred adult ill patients were prospectively included for urine measurements at four time-points prior to (T = 0, -16, -20 and -24 h)....
Because of the delayed rise serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers.Twenty-six consecutive adult liver transplantations were evaluated. Markers measured at four different time points during an intensive care unit admission.Plasma NGAL detected AKI with optimal area under curve 8 h after admission (0.86; p = 0.004) 4 for urinary (0.80; 0.012). The other markers...
Acute kidney injury (AKI) necessitating renal replacement therapy (RRT) is associated with high mortality and increased risk for end stage disease. However, it unknown if this applies to patients a preliminary unremarkable medical history. The purpose of study was describe overall survival in critically ill AKI RRT stratified by the presence comorbidity.A retrospective cohort performed, between 1994 2010, including all adult RRT, comorbidity. Logistic regression, curve cox proportional...
Chronic kidney disease (CKD) remains unexplained in at least 20% of patients. Massively parallel sequencing (MPS) can be a valuable diagnostic tool patients with CKD, but prospective data from routine clinical practice are limited. We aimed to determine the yield and relevance MPS-based gene panel testing CKD real-world context. additionally examined barriers implementation genetic testing. In this cohort study, we recruited (eGFR <60mL/min/1.73 m2 without underlying diagnosis) onset <50...
Renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) is associated high mortality. However, little known about the prognosis of renal function after ICU discharge and effect persisting impaired on long-term survival. The objective this study was to evaluate overall mortality a cohort AKI necessitating RRT. We hypothesized that both patient characteristics degree insufficiency at hospital will influence