A5047895435- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- Orthopedic Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Emotions and Moral Behavior
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Psychology of Moral and Emotional Judgment
- Streptococcal Infections and Treatments
- Effects and risks of endocrine disrupting chemicals
- Data Mining Algorithms and Applications
- Carcinogens and Genotoxicity Assessment
- Immune Cell Function and Interaction
- Cardiac, Anesthesia and Surgical Outcomes
- Evolutionary Psychology and Human Behavior
- Psychology of Social Influence
- Evolutionary Game Theory and Cooperation
- Cardiac and Coronary Surgery Techniques
- Economic and Financial Impacts of Cancer
- Deception detection and forensic psychology
- Immune responses and vaccinations
Deutsches Herzzentrum München
2025
Deutsches Herzzentrum der Charité
2006-2024
Humboldt-Universität zu Berlin
1998-2024
Charité - Universitätsmedizin Berlin
1998-2024
Adelphi Group (United Kingdom)
2024
Universidade Estadual Paulista (Unesp)
2024
Freie Universität Berlin
2021-2024
Berlin Heart (Germany)
2021-2022
German Centre for Cardiovascular Research
2018-2022
Zimmer Biomet (Germany)
1998-2001
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathology, it remains unclear whether T cells contribute disease pathology. Here, we combined single-cell transcriptomics proteomics with mechanistic studies assess pathogenic cell functions inducing signals. We identified highly activated CD16
We compared early and long-term results of cryopreserved homograft aortic root replacement in native valve endocarditis or prosthetic associated with periannular abscess.Between May 1986 December 2007, 1163 patients were operated upon. Of these, 221 (n = 185 men, median age 55 years) had due to 99 cases (45%) 122 (55%). Perinannular abscess developed 189 (86%), aortoventricular dehiscence 120 (63.5%) them. Perioperative characteristics, probability survival, freedom from recurrence,...
In the third report of European Registry for Patients with Mechanical Circulatory Support Association Cardio-Thoracic Surgery, outcomes patients receiving mechanical circulatory support are reviewed in relation to implant era.Procedures adult (January 2011-June 2020) were included. from centres <60% follow-ups completed excluded. Outcomes stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) calculated early phase (<3 months) late (>3 months). Risk factors...
Background Among other preoperative parameters, extremely low or high body mass index (BMI) has been discussed as a substantial risk factor for postoperative complications after cardiac surgery. However, the exact relationship between BMI and not yet defined.
Abstract We review the classic studies on social influence and fundamental attribution error to determine (a) whether it is true that behavior of sort observed in those externally caused two senses external causality used by theorists, (b) laypeople have been shown overestimate extent which internally either senses, (c) there a better way characterize errors people make. conclude has not be different sense internal versus characterizes make, (d) these literatures taken together suggest...
We retrospectively analysed the profile and outcome of surgically treated patients with active infective prosthetic valve endocarditis (PVE) over a period 22 years.Between May 1986 December 2008, total 1313 (AIE) were operated on, 349 (26.6%) them for PVE. Of these, 77 (22.1%) had to be upon due early PVE (≤60 days, n=55 men, median age: 58 years) 272 (77.9%) late (n=200 63 years). A large proportion referred our department advanced in condition cardiac pulmonary decompensation. 226 (64.8%)...
OBJECTIVEAcute kidney injury (AKI) requiring renal replacement therapy (RRT) after heart transplantation (OHT) is common and impairs outcomes. This study aimed to identify independent donor recipient risk factors associated with RRT OHT.DESIGNRetrospective data analysis.SETTINGThe were collected from clinical routines in a maximum care university hospital.PARTICIPANTSPatients who underwent OHTINTERVENTIONSThe authors retrospectively analyzed 264 patients OHT between 2012 2021. 189 eligible...
Abstract We investigated some types of triggers embarrassment and their personality correlates. A total 161 undergraduates indicated how embarrassed they would be in a variety situations classified priori into three types. The were based on the kind trigger embodied derived part from current theories embarrassment. Several analytic techniques, including factor analysis, suggested that there are at least sorts people find embarrassing: committing faux pas, being centre attention, threatening...
The implantable continuous-flow left ventricular assist devices (LVADs) HeartMate II (HM II) and HeartWare HVAD (HW) underwent design modifications. impact of these changes on life-threatening pump malfunctions was evaluated.We retrospectively analysed due to thrombosis or cable damage in patients supported with primarily implanted HM (n = 191) HW 347), separated into the old new designs. In 2010, strain relief device improved (132 79 new) sealed grafts were introduced (68 inflow connector...
Abstract Objectives The aim of this study was to investigate whether echocardiographic assessment myocardial work is a predictor outcome in patients undergoing operative revascularization. Background Global index (GWI) calculated by means speckle tracking, blood pressure measurement at the moment strain analysis, and normalized reference curve. prognostic value GWI who are scheduled for bypass surgery unknown. Methods In retrospective 193 operation were tracked using calculation Longitudinal...
Abstract Aims Assessing frailty and sarcopenia is considered a valuable cornerstone of perioperative risk stratification in advanced heart failure patients. The lack an international consensus on diagnostic standard impedes its implementation the clinical routine. This study aimed to compare feasibility prognostic impact different assessment tools patients undergoing continuous‐flow left ventricular assist device (cf‐LVAD) implantation. Methods results We prospectively compared values six...
Temporary mechanical circulatory support (tMCS) is a life-saving treatment option for patients in cardiogenic shock (CS), but many aspects such as patient selection, initiation threshold and optimal modality selection remain unclear. This study describes standard operating procedure (SOP) tMCS allocation CS presents outcome data before after implementation. Data from 421 treated with between 2018 2021 were analyzed. In 2019, we implemented new SOP allocating to modalities. The association...
Abstract Background Obesity is a known cardiovascular risk factor and associated with higher postoperative complication rates in patients undergoing cardiac surgery. In heart failure (HF), conflicting evidence terms of survival has been reported, whereas sarcopenia poor prognosis. An increasing number HF require left ventricular assist device (LVAD) implantations. The mortality improved recent years but still relatively high. impact body composition on outcome this population remains...
Background and methods Microaxial left ventricular assist devices are used increasingly for treating cardiogenic shock. We compared the short-term outcome of patients supported with different microaxial A retrospective propensity score-adjusted analysis was performed in shock treated either Impella CP (n = 64) or 5.0/5.5 62) at two tertiary cardiac care centers between 1/14 12/19. Results Patients group were significantly older (69.6 ± 10.7 vs. 58.7 11.9 years, p .001), more likely INTERMACS...
<b><i>Background and Objectives:</i></b> The 6-minute walk test (6MWT), as a clinical assessment tool for functional exercise capacity, is an integral component of lung allocation scores (LASs). In times the coronavirus disease (COVID-19) pandemic, patients underwent 6MWTs wearing surgical mask in ambulatory care. We investigated impact on distances (6MWDs). <b><i>Method:</i></b> 6MWDs 64 with end-stage diseases oronasal were retrospectively...
In 3 studies, we asked participants to report on their own emotional experience in specific scenarios, and predict how others would respond. line with speculation the literature, Study 1 found underestimation of percentage who embarrassment. We also truly false consensus effects. 2 experiences inhibition due embarrassment, commonly had been inhibited. evidence a effect but no effect. 3, that underestimated probability other people experiencing anger, fear, guilt, jealousy, joy, shame. again...
Nonparametric statistical classification methods that work without specific requirements to the distribution of underlying data play an important role especially in medical applications. Such a method is "Classification and Regression Trees" (CART), already suggested by Sonquist, 1970 improved later on Breiman et al., 1984. Of essential importance for practice assessment validity tree obtained. In this paper resampling-methods are used purpose. With construction resulting from validation...
Mitral regurgitation (MR) is frequently observed in patients undergoing left ventricular assist device implantation. We investigated the impact of preoperative MR on patients.A retrospective propensity score-matched analysis adult enrolled EUROMACS registry between 1 January 2011 and 30 November 2021 was performed. Patients were divided into 2 groups according to grade MR: none-to-mild (MR 0-II) or moderate-to-severe III-IV).Following 1:1 score matching, each group consisted 914 patients....