At present, the world is facing a pandemic named as COVID-19, caused by SARS-CoV-2. Traditional Chinese medicine has recommended use of liquorice (Glycyrrhiza species) in treatment infections Therefore, present investigation was carried out to identify active molecule from against different protein targets COVID-19 using an

Background: Saudi Arabia has passed through lifestyle changes toward unhealthy dietary patterns such as high fast food consumption. Adolescents and young adults, particularly girls, are the main groups exposed to affected by these adverse eating behaviors.Objective: The aim of this study was examine trends consumption among adolescent adult girls living in Riyadh, compare between them.Design: In a cross-sectional survey, 127 (13–18 years) 69 (19–29 were randomly recruited participate study....

Abstract An ultra high performance liquid chromatography‐tandem mass spectrometric method has been developed for the highly sensitive and selective determination of regulated aflatoxins. The extraction aflatoxins from baby food matrices were performed using liquid–liquid procedure followed by immunoaffinity column cleanup. higher sensitivity target was fulfilled applying a preconcentration step with columns after acetonitrile–water extraction. enhanced selectivity attained triple quadrupole...

Context Kaempferol, a flavonoid glycoside, has many hepatoprotective effects in several animals due to its antioxidant potential.Objective This study evaluated the effect of kaempferol against acetaminophen (APAP)-induced liver damage and examined whether protection involved modulation silent information regulator 1 (SIRT1) signalling.Materials methods Adult male Wistar rats were classified into four groups (n = 8) treated as follows: control + normal saline (vehicle), (250 mg/kg), APAP (800...

Vitamin D deficiency has emerged as a public health problem worldwide due to its important role in and disease. The present work is intended examine prevalence of vitamin among pregnant Saudi women related risk factors. A cross-sectional study was carried out at King Fahad Medical City Riyadh, Arabia. Serum 25-hydroxy (25(OH)D) measured by enzyme-linked immunosorbent assay 160 during the first trimester pregnancy. Socio-demographic, lifestyle maternal characteristics were collected intake...

An UPLC- mass spectrometry method has been proposed for the screening of carbaryl residues in fresh vegetables. Carbaryl treated samples lettuce, cucumber and spinach were procured analyzed a time period fifteen days to find out amount residue. A simple effective liquid–liquid sample extraction technique implemented carbaryl. Multiple reactions monitoring analysis mode considering two daughter transitions was used quantitation confirmation The developed authenticated by establishing various...

Vitamin D deficiency is an epidemic public health problem worldwide. It common in the Middle East and more severe women. This cross-sectional study was conducted to assess vitamin associated risk factors women living Riyadh, Saudi Arabia. Serum 25-hydroxyvitamin (25(OH)D) measured 166 aged 30-65 years. Socio-demographic, lifestyle status characteristics, as well intake of selected dietary supplements, were collected. Weight height measured. (25(OH)D < 20 ng/mL) reported 60.2% participants....

Endoplasmic reticulum (ER) stress plays a key role in cadmium chloride (CdCl2)-induced nephrotoxicity. Sirtuin-1 (SIRT1) is potent inhibitor of ER stress. In this study, we examined whether the protective effect quercetin (QUR) against CdCl2-induced nephrotoxicity rats involved modulation SIRT1 and/or Adult male were divided into five groups (n = 8, each) and treated for eight weeks as follows: control, control + QUR, CdCl2, CdCl2 QUR EX-527 (a inhibitor). Treatment with preserved glomerulus...

This study investigated if cadmium chloride (CdCl2 )-induced hepatic steatosis and fibrosis the protective effect of quercetin (QUR) are mediated modulating activity miR-21, a known lipogenic fibrotic miRNA. Male rats (n = 8/group) were divided as control, control + QUR (50 mg/kg; orally), CdCl2 (10 moml/L; drinking water), miR-21 antagomir (inhibitor) (16 mg/kg/first 3 days), mg/kg). Treatments conducted for 20 weeks, daily. All treatments showed no on fasting glucose insulin levels....

Abstract Bay laurel ( Laurus nobilis L.) contains active antioxidative phenolic components that are beneficial to human health. However, none was examined and reported utilizing health effects related inflammatory bowel diseases (IBD) mainly ulcerative colitis (UC) in correlation gut microbiota (GM). Thus, the current study aimed investigate impacts of bay leaves on UC albino rats targeting GM composition their metabolites production (i.e., short‐chain fatty acids; SCFAs) for improving...

Context Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia.Objective This study examined if AMPK mediates the anti-steatotic effect of ellagic streptozotocin (STZ)-induced type 1 diabetes mellitus rats.Materials and methods Adult male Wistar rats (130 ± 10 g) were divided into 6 groups (n = 8 rats/group) as control, control + EA, EA CC an inhibitor), T1DM, T1DM CC. The treatments with (50 mg/kg/orally) (200 ng/rat/i.p.) given desired for 12 weeks, daily.Results In...

A liquid–liquid extraction based high performance liquid chromatography-fluorescence method has been proposed for the quantitation of naturally producing aflatoxins in nuts and nut products. Aflatoxins from products was involved methanol – water extraction, immunoaffinity column cleanup followed by post derivatization technique. The gel contents monoclonal antibody are very specific to toxins interest, which makes experiment rapid, simple, highly sensitive. Additionally, improve...

Shrimp is a prevalent food in the Arabian Gulf that known for its good sensory properties and high nutritional value. The aim of present work was to assess effects diverse processing methods on composition shrimp antioxidant activity powder. (Penaeus semisulcatus) flesh treated using four processes (salting, frying, grilling, boiling), following which macronutrient content, fatty acid profile, vitamins mineral contents were measured. Also, all powder extracts assessed 2, 2 diphenyl 1...

Regular physical activity is essential for lifelong optimal health. Contrarily, inactivity linked with risk many chronic diseases. This study was conducted to evaluate the levels and factors associated among a multi-ethnic population of young men living in Saudi Arabia. cross-sectional involving 3,600 (20-35 years) Riyadh, Sociodemographic data were collected from subjects by face-to-face interviews. Physical characteristics evaluated using Global Activity Questionnaire. Weight height...

Twenty-nine Yemeni honey samples were analyzed to determine total phenolic and flavonoid contents using Folin-Ciocalteu spectrophotometric technique. These tested collected from different regions corresponding various floral species: jujube, cactus multifloral plants. method was adopted for the analysis of contents. Gallic acid quercetin considered as best standards response these compounds are equivalent most other acids compounds, respectively. The obtained results in a wide range; highest...

This study examined if the Fisetin against streptozotocin-induced diabetic cardiomyopathy (DC) in rats involves regulating cardiac metabolism and suppressing protein kinase R (PKR). Male were divided (12/groups) as control (non-diabetic), + Fisetin, T1DM, T1DM Fisetin. was administered orally at a final dose of 2.5 mg/kg for 12 weeks. In T1DM1-induced rats, prevented heart body weights loss, lowered circulatory levels troponin I creatinine kinase-MB (CK-MB), increased fasting insulin levels,...

This study examined if the protective effect of Ellagic acid (EA) against streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats involves activation Nrf2. Diabetes mellitus was induced by a single i.p dose STZ (65 mg/kg). The Rats were divided into 5 groups (n = 12/each) and treated for 8 weeks as control, control + EA (100 mg/kg), STZ, trigonelline (Nrf2 inhibitor/0.2 prevented renal damage, oxidative stress, inflammation, apoptosis. These effects associated with reduced activity...

Aloe perryi (ALP) is an herb that has several biological activities such as antioxidant, antibacterial, and antitumor effects frequently used to treat a wide range of illnesses. The activity many compounds augmented by loading them in nanocarriers. In this study, ALP-loaded nanosystems were developed improve their activity. Among different nanocarriers, solid lipid nanoparticles (ALP-SLNs), chitosan (ALP-CSNPs), CS-coated SLNs (C-ALP-SLNs) explored. particle size, polydispersity index (PDI),...

This study examined the protective effect of 11-keto-β-boswellic acid (AKBA) against streptozotocin (STZ)-induced diabetic cardiomyopathy (DC) in rats and possible mechanisms action. Male were divided into 5 groups (n = 8/each): (1) control, AKBA (10 mg/kg, orally), STZ (65 i.p.), + compound C (CC/an AMPK inhibitor, 0.2 i.p.). improved structure systolic diastolic functions left ventricles (LVs) rats. It also attenuated increase plasma glucose, insulin, serum hepatic levels triglycerides...

Background: Iron deficiency is known to be the most common nutritional disorder. About 30% of world’s population iron deficient (ID). Women are more likely exposed anemia than men, which an epidemic public health problem. Objective: A cross-sectional study was carried out investigate prevalence and associated risk factors among non-pregnant women in Riyadh, Saudi Arabia. Methods: Non-pregnant (n = 250) aged 20– 65 years were involved this study. Sociodemographic, status, menstrual history,...

Breakfast skipping is linked with obesity incidence. This study was conducted to assess the prevalence of breakfast among a multi-ethnic population young men residing in Saudi Arabia and its relationship sociodemographic determinants weight status. A total 3600 aged 20 35 years living Riyadh, Arabia, were involved this cross-sectional study. Sociodemographic breakfast-consumption frequency collected from subjects by personal interviews. defines as at least one day per week. Weight height...

The date palm is widely known as a richer nutritional source and natural medical agent. Date fruit major of carbohydrates dietary fiber, it has contains proteins, minerals, vitamins, phenolic compounds, carotenoids, sterols, triterpenoids. beneficial potential this well in Arab countries even the world. many health benefits such Glucose-lowering potential, anti-cancer activity, antioxidant hypocholesterolemia-lowering antimicrobial anti-inflammatory bone stimulating which attributed to...