A5069465371- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Invertebrate Immune Response Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Hereditary Neurological Disorders
- Genetic Neurodegenerative Diseases
- Insect Resistance and Genetics
- RNA Research and Splicing
- RNA regulation and disease
- Advanced biosensing and bioanalysis techniques
- Coenzyme Q10 studies and effects
- Plant Genetic and Mutation Studies
- Digestive system and related health
- Effects of Radiation Exposure
- Botulinum Toxin and Related Neurological Disorders
Buck Institute for Research on Aging
2019-2025
Jackson Laboratory
2021-2025
Defeating peripheral neuropathy The mechanisms underlying neuropathies are not well understood. Spaulding et al . studied mouse models of the inherited Charcot-Marie-Tooth (CMT) disease, which is caused by mutations in transfer RNA (tRNA) synthetases. Changes gene expression and rate protein synthesis neurons spinal cord triggered cell stress response activated sensor GCN2. When GCN2 was genetically deleted or inhibited with drugs, blocked, much milder. Zuko found that mutant glycyl-tRNA...
Aging | doi:10.18632/aging.206224. Sudipta Bar, Tyler A.U. Hilsabeck, Blaine Pattavina, José Alberto López-Domínguez, Nathan Basisty, Joanna Bons, Mark Watson, Birgit Schilling, Judith Campisi, Pankaj Kapahi, Amit Sharma
Abstract Exposure to genotoxic stress by environmental agents or treatments, such as radiation therapy, can diminish healthspan and accelerate aging. We have developed a Drosophila melanogaster model study the molecular effects of radiation-induced damage repair. Utilizing quantitative intestinal permeability assay, we performed an unbiased GWAS screen (using 156 strains from Genetic Reference Panel) search for natural genetic variants that regulate gut in adult D. . From this screen,...
Abstract The underlying causes of aging remain elusive, but may include decreased intestinal homeostasis followed by disruption the barrier, which can be mimicked nutrient‐rich diets. S3QELs are small‐molecule suppressors site III Qo electron leak; they suppress superoxide generation at complex mitochondrial transport chain without inhibiting oxidative phosphorylation. Here we show that feeding different to Drosophila on a high‐nutrient diet protects against greater permeability, enterocyte...
Abstract Background Charcot–Marie–Tooth disease type 1X is caused by mutations in GJB1 , which the second most common gene associated with inherited peripheral neuropathy. The encodes connexin 32 (CX32), a gap junction protein expressed myelinating glial cells. X‐linked, and cause loss of function. Aims A large number disease‐associated variants have been identified, many result mistrafficking mislocalization protein. An existing knockout mouse lacking Gjb1 expression provides valid animal...
Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects radiation-induced on intestine. In this model, examined irradiation-responsive senescence in fly Through an unbiased genome-wide association study (GWAS) utilizing 156 strains from Genetic Reference Panel (DGRP), identified meltrin β (the drosophila orthologue mammalian ADAM19) as potential modulator senescence-associated secretory phenotype...
Abstract Exposure to genotoxic stress by environmental agents or treatments, such as radiation therapy, can diminish health span and accelerate aging. We have developed a Drosophila melanogaster model study the molecular effects of radiation-induced damage repair. Utilizing quantitative intestinal permeability assay, we performed an unbiased GWAS screen (using ∼150 strains from DGRP reference panel) search for natural genetic variants that regulate gut permeability. From this screen,...