A5056002165- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- RNA and protein synthesis mechanisms
- Sulfur-Based Synthesis Techniques
- Asymmetric Hydrogenation and Catalysis
- Molecular Sensors and Ion Detection
- SARS-CoV-2 detection and testing
- Luminescence and Fluorescent Materials
- Phytochemistry and Biological Activities
- Synthesis and Catalytic Reactions
- Bacteriophages and microbial interactions
- HIV/AIDS drug development and treatment
- Click Chemistry and Applications
- Malaria Research and Control
- Advanced Biosensing Techniques and Applications
- Chemical synthesis and alkaloids
- Synthetic Organic Chemistry Methods
- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Traditional and Medicinal Uses of Annonaceae
Chulalongkorn University
2016-2025
Royal Society of Chemistry
2023
University of Notre Dame
2023
Michigan State University
2023
The University of Texas at El Paso
2023
Stockholm University
2023
Curtin University
2023
Rutherford Appleton Laboratory
2023
Confederazione Nazionale dell'Artigianato e Della Piccola e Media Impresa
2023
Columbia University
2023
The development of simple fluorescent and colorimetric assays that enable point-of-care DNA RNA detection has been a topic significant research because the utility such in resource limited settings. most common motifs utilize hybridization to complementary strand coupled with sensitive reporter molecule. Here, paper-based assay for based on pyrrolidinyl peptide nucleic acid (acpcPNA)-induced nanoparticle aggregation is reported as an alternative traditional approaches. PNA probes are...
Malarial dihydrofolate reductase (DHFR) is the target of antifolate antimalarial drugs such as pyrimethamine and cycloguanil, clinical efficacy which have been compromised by resistance arising through mutations at various sites on enzyme. Here, we describe use cocrystal structures with inhibitors substrates, along pharmacokinetic profiling for design, characterization, preclinical development a selective, highly efficacious, orally available drug candidate that potently inhibits both...
Until now, an electrochemical lateral flow assay (eLFA) capable of detecting nucleic acids has remained a challenge and been scarcely explored because its complicated multistep nature. Here, we report automated paper-based eLFA device for the quantitative detection hepatitis B virus (HBV)—the major cause liver cirrhosis hepatocellular carcinoma (HCC). Using time-delayed microfluidic strategy fabricated on paper, precisely sequenced solution transfer was enabled by single sample loading. A...
Addition reactions to imines are relatively less developed compared those of carbonyl compounds due low electrophilicity and ease α-deprotonation. With the use an appropriate activator, which can coordinate imine nitrogen atom, be enhanced a range nucleophilic addition becomes possible. When activator is chiral, it will also create chiral environment direct approach nucleophile one face over other resulting in enantioselectivity. The potential catalytic asymmetric organic synthesis enormous,...
A mixed-base, β-amino acid containing, pyrrolidinyl peptide nucleic (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA−DNA binding specificity strictly follows the Watson−Crick base-pairing rules.
ConspectusThe specific pairing between two complementary nucleobases (A·T, C·G) according to the Watson–Crick rules is by no means unique natural nucleic acids. During past few decades a number of acid analogues or mimics have been developed, and peptide (PNA) one most intriguing examples. In addition forming hybrids with DNA/RNA as well itself high affinity specificity, uncharged peptide-like backbone PNA confers several properties not observed in other classes analogues. therefore suited...
Abstract The activation of the sulfur atom thiols with (diacetoxyiodo)benzene (DIB) has been explored in preparation symmetrical disulfides and sulfenamides. Disulfides can be produced excellent yields (75–95 %) upon treatment DIB. reaction was complete less than five minutes at room temperature. Aliphatic, aromatic, heteroaromatic are compatible this transformation. Moreover, obtained from further reacted a nucleophilic amine presence base to provide corresponding sulfenamides fair good...
The objective of this study was to determine the interactions between selected strawberry esters and pea protein isolate (PPI) in a protein-containing aqueous model system, utilizing modified ultrafiltration equilibrium dialysis techniques. Strawberry esters, including ethyl butanoate, isopentanoate, hexanoate, methyl anthranilate, demonstrated different binding parameters PPI. Overall flavor affinities (nK) all decreased as temperature increased from 5 °C 25 °C. Among these compounds,...
2,2':6',2' '-Terpyridineplatinum(II) complexes are shown to possess cytotoxicity against a number of human ovarian tumor cell lines. Many the show similar activity cisplatin- and doxorubicin-resistant lines as parental cells suggesting that there is little or no cross-resistance with cisplatin doxorubicin. The bis[2,2':6',2' '-terpyridineplatinum(II)] strongly dependent on nature linker. Bis[2,2':6',2' flexible linker at 4'-position poor cytotoxicity; by contrast rigid short linkers...
A range of (2,2':6',2' '-terpyridine)platinum(II) complexes are shown to possess antiprotozoal activity in vitro against Leishmania donovani, Trypanosoma cruzi, and brucei, the causative organisms tropical diseases leishmaniasis trypanosomiasis. The best compounds caused 100% 78% inhibition growth intracellular amastigote forms L. donovani T. respectively, at a concentration 1 μM bloodstream trypomastigote brucei 0.03 μM. results obtained with which fourth ligand platinum(II) is capable...
Novel analogues of pyrimethamine (Pyr) and cycloguanil (Cyc) have been synthesized tested as inhibitors Plasmodium falciparum dihydrofolate reductase carrying triple (N51I+C59R+S108N, C59R+S108N+I164L) quadruple (N51I+C59R+S108N+I164L) mutations responsible for antifolate resistance. The were designed to avoid steric clash the p-Cl group with side chain Asn108, augmented by additional resistant mutants. Cycloguanil derivatives also Val16 in A16V+S108T mutant. Many compounds inhibition...