A5091096322- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Pharmacological Effects and Assays
- Pesticide Residue Analysis and Safety
- Adrenal Hormones and Disorders
- Muscle metabolism and nutrition
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Biosimilars and Bioanalytical Methods
- Diet, Metabolism, and Disease
- Doping in Sports
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Stress Responses and Cortisol
- Lung Cancer Research Studies
- Phytoestrogen effects and research
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pharmaceutical Economics and Policy
- COVID-19 Impact on Reproduction
University of Turin
2020-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2022-2023
University of Lausanne
2015-2020
University Centre of Legal Medicine
2015-2020
University Hospital of Lausanne
2015-2019
Volumetric Absorptive Microsampling (VAMS) is emerging as a valuable technique in the collection of dried biological specimens, offering potential alternative to traditional sampling methods. The objective this study was assess suitability 30 μL VAMS for measurement endogenous steroid hormones.
Detection of endogenous anabolic androgenic steroids (EAAS), like testosterone (T), as doping agents has been improved with the launch Steroidal Module Athlete Biological Passport (ABP) in urine samples.
Abstract Context Adrenal venous sampling (AVS) is the gold standard procedure for subtype diagnosis in patients with primary aldosteronism (PA). Cortisol usually adopted normalization of aldosterone levels peripheral and adrenal samples. However, asymmetrical cortisol secretion can potentially affect lateralization index, leading to misdiagnosis. Objective We aimed assess prevalence undergoing AVS whether variations vein might influence interpretations. then evaluated use metanephrines...
Aim: Quantification of testosterone (T) and 5α-dihydrotestosterone serum concentrations proved to be an efficient alternative urinary steroid profiling for the detection T doping. In this context, additional markers could discovered by exploratory untargeted steroidomics studies. Results: Endogenous metabolites were monitored ultra high-performance liquid chromatography coupled high-resolution mass spectrometry in samples collected during a administration clinical trial. A three-step...
Aim: Quantitative endogenous steroid profiling in blood appears as a complementary approach to the urinary module of World Anti-Doping Agency's Athlete Biological Passport Steroidal Module for detection testosterone doping. To refine this further, UHPLC–MS/MS method was developed simultaneous determination 14 free and conjugated steroids serum. Results: The validated quantitative purposes with satisfactory results terms selectivity, linearity range, trueness, precision combined uncertainty...
The systematic use of confirmatory tests in the diagnosis primary aldosteronism (PA) increases costs, risks and complexity to diagnostic work-up. In light this, some authors proposed aldosterone-to-renin (ARR) cut-offs and/or integrated flow-charts avoid this step. Patients with resistant hypertension (RH), however, are characterized by a dysregulated renin-angiotensin-aldosterone system, even absence PA. Thus, it is unclear whether these strategies might be applied same reliability setting...
In type 2 diabetes mellitus (T2DM), the antidiuretic system participates in adaptation to osmotic diuresis further increasing urinary osmolality by reducing electrolyte-free water clearance. Sodium glucose co-transporter inhibitors (SGLT2i) emphasize this mechanism, promoting persistent glycosuria and natriuresis, but also induce a greater reduction of interstitial fluids than traditional diuretics. The preservation homeostasis is main task and, turn, intracellular dehydration drive...
Background and Aim: Asymmetric dimethylarginine (ADMA) symmetric (SDMA) have been proposed as mediators of endothelial dysfunction.In this study, we aimed to investigate the diagnostic prognostic role ADMA SDMA in acute cerebrovascular disease. Methods Results:A prospective case-control study was performed, enrolling 48 patients affected by ischemic stroke with no cardioembolic origin, 20 TIA, 40 subjects at high cardiovascular risk 68 healthy subjects.ADMA levels were significantly lower...
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect testicles. Lower testosterone levels have been associated with worse clinical outcomes and higher mortality. Our objective was to evaluate the hypothalamic−pituitary−gonadal axis of men admitted SARS-CoV-2 pneumonia its link pneumonia-treatment intensification. Short-term changes in hormonal parameters were also assessed. Methods: Men recruited two different hospitals Piedmont, Italy. In all patients,...
The simultaneous measurement of dexamethasone and cortisol has proven the ability to increase diagnostic performance overnight dexamethasone-suppression test. Furthermore, therapeutic drug monitoring administered corticosteroid drugs could represent a crucial tool for investigating unexpected variations steroid hormones' circulating levels. In this work, an LC-MS/MS method quantification cortisol, cortisone, six additional exogenous corticosteroids in serum/plasma matrix was developed...