A5018923390- CRISPR and Genetic Engineering
- Hemoglobinopathies and Related Disorders
- Prenatal Screening and Diagnostics
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Heterotopic Ossification and Related Conditions
- Adipose Tissue and Metabolism
- Sleep and related disorders
- Neuroendocrine regulation and behavior
- Orthopaedic implants and arthroplasty
- Dietary Effects on Health
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Behavioral Health and Interventions
- Angiogenesis and VEGF in Cancer
- Parvovirus B19 Infection Studies
- Bullying, Victimization, and Aggression
- TGF-β signaling in diseases
- Animal Nutrition and Physiology
- Genetic Syndromes and Imprinting
- Vestibular and auditory disorders
The University of Texas at Austin
2021-2025
Sanofi (United States)
2019-2024
Sanofi (France)
2019
Baylor College of Medicine
2007-2011
ABSTRACT In male hamsters, puberty is associated with increased serotonin innervation and unusual responses to fluoxetine, such as enhanced play‐fighting activity against intruders but also an acceleration of its maturation from attacks focused on the face (frontal attacks) lower belly rump, suggesting a role for (5‐HT). We tested 5‐HT 1A 3 receptor subtypes behavior observed during resident intruder tests through peripheral treatment agonists antagonists. Contrary observations in adult we...
Synthesis of bone requires both essential progenitors to form the various structures and correct microenvironment for their differentiation. To identify these factors, we have used a system that exploits morphogenetic protein's ability induce endochondral formation rapidly. One earliest events observed was influx proliferation fibroblastic cells express vascular smooth muscle cell markers, alpha actin (alpha SMA), myosin heavy chain, monocytic marker CD68. The expression factors lost by days...
In male hamsters, puberty is associated with increased serotonin innervation and unusual responses to fluoxetine, such as enhanced play-fighting activity against intruders but also an acceleration of its maturation from attacks focused on the face (frontal attacks) lower belly rump, suggesting a role for (5-HT). We tested 5-HT1A 5-HT3 receptor subtypes behavior observed during resident/intruder tests through peripheral treatment agonists antagonists. Contrary observations in adult we didn't...
BIVV003 is a gene-edited autologous cell therapy in clinical development for the potential treatment of sickle disease (SCD). Hematopoietic stem cells (HSC) are genetically modified with mRNA encoding zinc finger nucleases (ZFN) that target and disrupt specific regulatory GATAA motif BCL11A erythroid enhancer to reactivate fetal hemoglobin (HbF). We characterized ZFN-edited HSC from healthy donors SCD. Results preclinical studies show ZFN-mediated editing highly efficient, enriched biallelic...
Abstract Juvenile male hamsters exposed to chronic social stress eat more, gain weight, and have larger fat pads. The purpose of the present study was address possible changes in food hoarding orexin/hypocretin innervation response stress. Male early adolescence were a resident‐intruder paradigm or control condition daily for 2 weeks. Metabolism‐related physiological measures behaviors tracked, brains immunocytochemically labeled orexin‐A. Our data confirm our previous observations on...
Background: High fetal hemoglobin (HbF) levels are associated with decreased severity in sickle cell disease (SCD) and beta thalassemia (BT). We developed a novel gene‐edited therapy using autologous hematopoietic stem progenitor cells (HSPCs) that have been genetically modified zinc finger nucleases (ZFNs) to reactivate HbF expression. The ZFNs target the GATA1 binding motif (GATAA) within an intronic erythroid‐specific enhancer (ESE) of BCL11A , which encode major repressor HbF....