A5089057439- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Listeria monocytogenes in Food Safety
- Probiotics and Fermented Foods
- Gut microbiota and health
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Microbial Community Ecology and Physiology
- Tactile and Sensory Interactions
- Prosthetics and Rehabilitation Robotics
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Identification and Quantification in Food
- Pressure Ulcer Prevention and Management
- Genomics and Phylogenetic Studies
- Yersinia bacterium, plague, ectoparasites research
- Plant Pathogenic Bacteria Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Essential Oils and Antimicrobial Activity
Massachusetts General Hospital
2021-2025
Harvard University
2020-2025
Boston VA Research Institute
2021
University of California, Davis
2014-2018
University of Tarapacá
2014
National Yang Ming Chiao Tung University
2014
Abstract Dietary prebiotic oligosaccharides are common in people’s diets; however, little is known about how different prebiotics alter the enteric epithelium and microbiome. Here we show two structurally oligosaccharides, human milk (HMO) mannanoligosaccharides (MOS), metabolism of colonic epithelial cells Salmonella enterica sv. Typhimurium ways specific to each prebiotic. Initially, HMO MOS addition decreased S. association with cells. However, gene expression analysis revealed...
Prebiotic oligosaccharides are used to modulate enteric pathogens and reduce pathogen shedding. The interactions with prebiotics that alter Listeria monocytogenes infection not yet clearly delineated. L. cellular invasion requires a concerted manipulation of host epithelial cell membrane receptors initiate internalization often via receptor glycosylation. Bacterial glycans intimately involved in modulating responses through signaling cascades at the intracellular compartments. Characterizing...
Listeria monocytogenes is a bacterial pathogen that found in wide variety of anthropogenic and natural environments. Genome sequencing technologies are rapidly becoming powerful tool facilitating our understanding how genotype, classification phenotypes, virulence phenotypes interact to predict the health risks individual isolates. Currently, 57 closed L. genomes publicly available, representing three four phylogenetic lineages, they suggest has high genomic synteny. This study contributes...
Campylobacter is a food-associated bacterium and leading cause of foodborne illness worldwide, being associated with poultry in the food supply. This initial public release 202 genome sequences as part 100K Pathogen Genome Project. These isolates represent global genomic diversity genus.
Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This public release of 1,183 draft genome sequences as part 100K Pathogen Genome Project. These isolates represent genomic diversity in genus.
Many bacterial pathogens require a type 3 secretion system (T3SS) to establish niche. Host contact activates T3SS assembly of translocon pore in the host plasma membrane. Following formation, docks onto pore. Docking establishes continuous passage that enables translocation virulence proteins, effectors, into cytosol. Here we investigate contribution actin polymerization T3SS-mediated translocation. Using model organism Shigella flexneri , show is required for assembling an open...
Bacterial surface ligands mediate interactions with the host cell during association that determines specific outcome for host-microbe association. The begins receptors on binding microbial to form a partnership initiates responses in both cells. Methods determine cognate partnerships are lacking. Determining these molecular between and surfaces difficult, yet crucial defining biologically important events triggered of microbiome, critical initiating signal from membrane results pathology or...
ABSTRACT Listeria monocytogenes is a food-associated bacterium that responsible for food-related illnesses worldwide. This the initial public release of 306 L. genome sequences as part 100K Pathogen Genome Project. These isolates represent global genomic diversity in .
Pressure ulcers can be a fatal complication. Many immobile wheelchair users face this threat. Current passive and active cushions do reduce the incidence of pressure they have different merits. We proposed an approach to combine their advantages which is based on concept that interface changed with supporting shapes. The purpose paper verify approach. With practical applications in mind, we developed modular system whose support surface composed by height-adjustable elements. Each...
Shigella spp. are human bacterial pathogens that cause bacillary dysentery. Virulence depends on a type 3 secretion system (T3SS), highly conserved structure present in multiple important and plant pathogens. Upon host cell contact, the T3SS translocon is delivered to membrane, facilitates docking enables delivery of effector proteins into cytosol. The composed two proteins, IpaB IpaC, which together form this multimeric within plasma membranes. interaction IpaC with intermediate filaments,...
Shigella is a major foodborne pathogen that infects humans and nonhuman primates the cause of dysentery reactive arthritis worldwide. This initial public release 16 genome sequences from four species sequenced as part 100K Pathogen Genome Project.
The use of percutaneous cranial implants in rhesus macaques (
Abstract Many bacterial pathogens require a type 3 secretion system (T3SS) to establish niche. Host contact activates T3SS assembly of translocon pore in the host plasma membrane. Following formation, docks onto pore. Docking establishes continuous passage that enables translocation virulence proteins, effectors, into cytosol. Here we investigate contribution actin polymerization T3SS-mediated translocation. Using model organism Shigella flexneri , show is required for assembling an open...
Abstract Shigella spp. are human bacterial pathogens that cause bacillary dysentery. Virulence depends on a type 3 secretion system (T3SS), highly conserved structure present in multiple important and plant pathogens. Upon host cell contact, the T3SS translocon is delivered to membrane, facilitates docking enables delivery of effector proteins into cytosol. The composed two proteins, IpaB IpaC, which together form this multimeric within plasma membranes. interaction IpaC with intermediate...