A5017372580- Viral Infections and Immunology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Menopause: Health Impacts and Treatments
- Heart Failure Treatment and Management
- Estrogen and related hormone effects
- Cardiac Fibrosis and Remodeling
- Regulation of Appetite and Obesity
- Cardiomyopathy and Myosin Studies
- Diabetes Treatment and Management
- Cardiac Imaging and Diagnostics
- Growth Hormone and Insulin-like Growth Factors
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Diabetes and associated disorders
- Hip and Femur Fractures
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Ion channel regulation and function
- Blood Pressure and Hypertension Studies
- Apelin-related biomedical research
- Cardiovascular Effects of Exercise
- Pancreatic function and diabetes
Kanazawa Medical University
2015-2024
Ajinomoto (United States)
2020
Weatherford College
2020
Community Medical Center
2013
Toyama City Hospital
2010
Gunma University
1995-2009
General Department of Preventive Medicine
2000-2009
Gunma University Hospital
1999-2003
Kanazawa Medical Center
2002
The University of Tokyo
2000-2001
Sphingosine 1-phosphate (S1P) stimulates thymidine incorporation (DNA synthesis), cell growth and migration in human aortic endothelial cells (HAECs). The extent of the S1P-induced responses are comparable to those stimulated by vascular factor, one most potent stimulators angiogenesis. These S1P were mimicked dihydrosphingosine 1-phosphate, an receptor agonist, inhibited pertussis toxin (PTX), inactivator Gi/Go-proteins. also induced activation extracellular signal-regulated kinase (ERK)...
We examined the actions of sphingosine 1-phosphate (S1P) on signaling pathways in Chinese hamster ovary cells transfected with putative S1P receptor subtypes, <i>i.e.</i> Edg-1, AGR16/H218 (Edg-5), and Edg-3. Among these receptor-transfected cells, there was no significant difference expressing numbers receptors their affinities to S1P, which were estimated by [<sup>3</sup>H]S1P binding cells. In vector-transfected slightly increased cytosolic Ca<sup>2+</sup> concentration...
Doxorubicin (DOX)-induced cardiomyopathy has been found to be associated with impaired Ca(2+) handling in the sarcoplasmic reticulum (SR), leading reduced cardiac function. We have recently demonstrated that expression of mRNA encoding sarco(endo)plasmic Ca(2+)-ATPase 2 (SERCA2), a major transport protein SR, is markedly decreased DOX-treated hearts. To extend this observation, we dissected molecular mechanisms by which DOX downregulates SERCA2 gene transcription. Using cultured rat neonatal...
Post-operative ileus (PI) is an inevitable adverse consequence of abdominal surgical procedures. We performed a randomized study the effects herbal medicine dai-kenchu-to (DKT) on 24 patients with PI. Patients received either 15 g oral DKT or placebo daily for 14 days. The upper gastrointestinal motility, frequency secondary operation and recurrence PI were investigated. was significantly lower in receiving compared placebo. Oral administration clinically effective reducing both need further surgery
We investigated the effect of interleukin-6 (IL-6) expression on sarco/endoplasmic reticulum Ca 2 +-ATPase (SERCA), atrial natriuretic peptide (ANP) and B-type (BNP) mRNA levels in cultured rat neonatal ventricular myocytes. IL-6 plays a key role regulating cardiac hypertrophy development heart failure, SERCA, ANP BNP are all hormones with regulatory properties. Compared baseline measurements, treatment 50 U/ml significantly decreased SERCA gene expression, but increased These results...
Acupuncture has recently been attracting more and people throughout the world as an alternative treatment, however little is known about its physiological activities (i.e. immune system). We examined acupuncture both quantitatively qualitatively by measuring CD-positive cell counts cytokine expression levels in blood, to determine activity of T cells, B macrophages natural killer (NK) cells. Fifteen milliliters peripheral blood obtained from 17 healthy volunteers aged 21-51 years, were...
More and more patients have been diagnosed as having chronic fatigue syndrome (CFS) in recent years. Western drug use for this is often associated with many side-effects little clinical benefit. As an alternative medicine, traditional Chinese medicine (TCM) has provided some evidences based upon ancient texts studies, not only to offer benefit but also insights into their mechanisms of action. It perceived advantages such being natural, effective safe ameliorate symptoms CFS fatigue,...
The prognosis for patients with idiopathic dilated cardiomyopathy (DCM) is poor, although clinical features are variable. Prediction of outcome has been difficult in individual based on laboratory data. In some DCM, myocardial damage secondary to viral or immune-mediated inflammation may persist. To objectively assess inflammation, we measured plasma concentrations C-reactive protein (CRP) 188 DCM over 5-8 years. All had dyspnea and fatigue at rest; all a left ventricular ejection fraction...
Exogenous sphingosine 1-phosphate (S1P) increased cytosolic Ca(2+) concentration, stimulated thymidine incorporation (DNA synthesis) and inhibited cell migration in rat aortic smooth-muscle cells (AoSMCs). Although exogenous sphingosine, a substrate of kinase or precursor S1P, markedly induced the intracellular accumulation lipid failed to mimic S1P-induced actions. In contrast, dihydrosphingosine (DHS1P), an S1P receptor agonist, duplicated these actions even though DHS1P was approx....
Abstract Aspiration pneumonia (AP) has been recognized as one of the most common postoperative complications after hip surgery in elderly. The objective present study was to evaluate risk for AP elderly patients with femoral neck fractures. We recruited 426 (age 84.9 ± 7.4 years) a history carried out at Toyama Municipal Hospital. occurred 18 cases (4.23%). Statistical test found significant differences age, gender, serum albumin level, and cognitive impairment, between non-AP groups....