Miles W. Mee
A5049378073- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Veterinary Oncology Research
- Protein Structure and Dynamics
- Virus-based gene therapy research
- Advanced Proteomics Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Biotin and Related Studies
- Computational Drug Discovery Methods
- Ubiquitin and proteasome pathways
- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
University of Guelph
2022-2024
University of Toronto
2019-2024
Ontario Institute for Cancer Research
2020-2022
Multi-omics datasets represent distinct aspects of the central dogma molecular biology. Such high-dimensional profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple using statistical fusion, rationalizes contributing evidence highlights associated genes. As part ICGC/TCGA Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing from...
Abstract In recent decades, the development of new drugs has become increasingly expensive and inefficient, molecular mechanisms most pharmaceuticals remain poorly understood. response, computational systems network medicine tools have emerged to identify potential drug repurposing candidates. However, these often require complex installation lack intuitive visual mining capabilities. To tackle challenges, we introduce Drugst.One, a platform that assists specialized in becoming...
Abstract Global insights into cellular organization and function require comprehensive understanding of interactome networks. Similar to how a reference genome sequence revolutionized human genetics, map the network is critical fully understand genotype-phenotype relationships. Here we present first “all-by-all” binary map, or “HuRI”. With ~53,000 high-quality protein-protein interactions (PPIs), HuRI approximately four times larger than information curated from small-scale studies available...
Deciphering the functional impact of genetic variation is required to understand phenotypic diversity and molecular mechanisms inherited disease cancer. While millions variants are now mapped in genome sequencing projects, distinguishing remains a major challenge. Protein-coding can be interpreted using post-translational modification (PTM) sites that core components cellular signaling networks controlling processes pathways. ActiveDriverDB an interactive proteo-genomics database uses more...
Knowing which proteins interact with each other is essential information for understanding how most biological processes at the cellular and organismal level operate their perturbation can cause disease. Continuous technical methodological advances over last two decades have led to many genome-wide systematically-generated protein–protein interaction (PPI) maps. To help store, visualize, analyze disseminate these specialized experimental datasets via web, we developed freely-available...
Summary Hundreds of different protein complexes that perform important functions across all cellular processes, collectively comprising the “complexome” an organism, have been identified 1 . However, less is known about fraction interactome exists outside complexome, in “outer-complexome”. To investigate features “inner”- versus outer-complexome organisation yeast, we generated a high-quality atlas binary protein-protein interactions (PPIs), combining three previous maps 2–4 and new...
Canine lymphoma, the most common hematological cancer in dogs, shares many molecular and clinical characteristics with human Non-Hodgkin lymphoma (NHL). The standard treatment for canine is "CHOP" multiagent chemotherapy protocol consisting of Cyclophosphamide, Doxorubicin (Hydroxydaunorubicin), Vincristine (Oncovin™), Prednisone. Approximately 70-85% patients treated CHOP achieve remission. However, duration remission varies majority dogs eventually relapse. To identify possible biomarkers...
Abstract The standard treatment for canine lymphoma is the CHOP chemotherapy regimen. Proteasome inhibitors have been employed with of human haematological malignancies but remain to be fully explored in lymphoma. We identified an association between poor response and high mRNA expression levels proteasomal subunits a cohort 15 patients, sought determine effect proteasome on viability B‐cell cell line (CLBL‐1). aim this study was investigate whether sensitize these cells agents doxorubicin,...
The majority of canine lymphoma patients treated with the standard care, CHOP chemotherapy protocol, initially achieve remission but eventually relapse a multi-drug-resistant phenotype. This study assesses gene expression profiles tumor cell populations using RNA-Seq data from 15 matched patient samples taken prior to treatment and again six weeks into CHOP. Two distinct clusters were present in t-SNE dimensionality reduction profiles. There was significant difference progression-free...