A5103176470- Mycorrhizal Fungi and Plant Interactions
- Plant Pathogens and Fungal Diseases
- Gut microbiota and health
- Forest Ecology and Biodiversity Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Fungal Biology and Applications
- Plant-Microbe Interactions and Immunity
- Genomics and Phylogenetic Studies
- Clostridium difficile and Clostridium perfringens research
- RNA Research and Splicing
- RNA modifications and cancer
- Plant Pathogenic Bacteria Studies
- Legume Nitrogen Fixing Symbiosis
- Bacteriophages and microbial interactions
- Bioinformatics and Genomic Networks
- S100 Proteins and Annexins
- Genetic Associations and Epidemiology
- Brucella: diagnosis, epidemiology, treatment
- Mycobacterium research and diagnosis
- Virus-based gene therapy research
- Connexins and lens biology
- Burkholderia infections and melioidosis
Canadian Food Inspection Agency
2023-2024
Children's Hospital of Eastern Ontario
2018-2021
University of Ottawa
2013-2018
Canadian Institute for Advanced Research
2013-2016
The mutualistic symbiosis involving Glomeromycota, a distinctive phylum of early diverging Fungi, is widely hypothesized to have promoted the evolution land plants during middle Paleozoic. These arbuscular mycorrhizal fungi (AMF) perform vital functions in phosphorus cycle that are fundamental sustainable crop plant productivity. unusual biological features AMF long fascinated evolutionary biologists. coenocytic hyphae host community hundreds nuclei and reproduce clonally through large...
Summary Arbuscular mycorrhizal fungi ( AMF ) are known to improve plant fitness through the establishment of symbioses. Genetic and phenotypic variations among closely related isolates can significantly affect growth, but genomic changes underlying this variability unclear. To address issue, we improved genome assembly gene annotation model strain Rhizophagus irregularis DAOM 197198, compared its content with five R . sampled in same field. All harbor striking variations, large numbers...
Summary Arbuscular mycorrhizal fungi ( AMF ) are important plant symbionts that have long been considered evolutionary anomalies because of their apparent long‐term lack sexuality, but recent explorations available DNA sequence challenged this notion by revealing the presence homologues fungal mating type – high‐mobility group MATA ‐ HMG and core meiotic genes in these organisms. To obtain more insights into sexual potential , s were sought transcriptome three isolates, functional...
Genomic variations comprise a spectrum of alterations, ranging from single nucleotide polymorphisms (SNPs) to large-scale structural variants (SVs), which play crucial roles in bacterial evolution and species diversification. Accurately identifying SNPs SVs is beneficial for subsequent evolutionary epidemiological studies. This study presents VariantDetective (VD), novel, user-friendly, all-in-one pipeline combining SNP SV calling generate consensus genomic using multiple tools.
Abstract Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, is an aggressive cancer with a poor prognosis. Despite current management, 5-year survival rate for patients metastatic RMS ∼30%; underscoring need to develop better treatment strategies. We have recently reported that pannexin 1 (PANX1) levels are downregulated and restoring its expression inhibits progression. Here, we surveyed characterized molecular changes induced by PANX1 re-expression RMS. cataloged...
Rare monogenic diseases affect millions worldwide; although over 4500 rare disease genotypes are known, disease-modifying drugs available for only 5% of them. The sheer number these conditions combined with their rarity precludes traditional costly drug discovery programs. An economically viable alternative is to repurpose established diseases. Many genetic result from increased or decreased protein activity and identification clinically approved which moderate this pathogenic dosage holds...
Abstract The global spread of antimicrobial resistance genes (ARGs) poses a significant threat to public health. While antibiotics effectively treat bacterial infections, they can also induce gut dysbiosis, the severity which varies depending on specific antibiotic treatment used. However, it remains unclear how dysbiosis affects mobility and dynamics ARGs. To address this, mice were pre-treated with streptomycin, ampicillin, or sulfamethazine, then orally inoculated Salmonella enterica...
The global spread of antimicrobial resistance genes (ARGs) poses a significant threat to public health. While antibiotics effectively treat bacterial infections, they can also induce gut dysbiosis, the severity which varies depending on specific antibiotic treatment used. However, it remains unclear how dysbiosis affects mobility and dynamics ARGs. To address this, mice were pre-treated with streptomycin, ampicillin, or sulfamethazine, then orally inoculated
This announcement reports the complete genome sequence of a non-Shiga toxin-producing Escherichia coli strain that was isolated from municipal biosolids collected Canadian wastewater treatment plant. contains multiple metal, antimicrobial, and heat resistance genes, as determined by sequencing, could be useful bacterial model for future studies.
Glanders is a highly contagious and life-threatening zoonotic disease caused by Burkholderia mallei (B. mallei). Without an effective vaccine or treatment, early diagnosis has been regarded as the most method to prevent glanders transmission. Currently, of heavily reliant on serological tests. However, given that markedly different host immune responses can be elicited genetically strains same bacterial species, infection B. mallei, whose genome unstable plastic, may result in various...