A5040486511- Escherichia coli research studies
- Cancer Immunotherapy and Biomarkers
- Antibiotic Resistance in Bacteria
- Urinary Tract Infections Management
- Cancer Cells and Metastasis
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Mosquito-borne diseases and control
- Pediatric Urology and Nephrology Studies
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- Veterinary medicine and infectious diseases
Institute for Molecular Medicine Finland
2022
University of Helsinki
2022
Koç University
2014-2021
We described the clinical predictive role of emerging Escherichia coli O25b/sequence type 131 (ST131) in treatment failure urinary tract infection.In this prospective observational cohort study, outpatients with acute cystitis isolation E. their urine cultures were assessed. All patients followed up for cure after 10 days treatment. Detection O25:H4/ST131 clone was performed by multiplex polymerase chain reaction (PCR) phylogroup typing and using PCR primers O25b rfb allele 3 pabB gene.In a...
We described the predictive role of cytokines in fatality Crimean Congo Hemorrhagic Fever Virus (CCHFV) infection by using daily clinical sera samples. Consequent serum samples selected patients different severity groups and healthy controls were examined human cytokine 17‐plex assay. included 12 (23%) mild, 30 (58%) moderate, 10 (19%) severe patients, volunteers. The mean age was 52 (sd 15), 52% female. Forty‐six (88%) received ribavirin. During disease course, median levels IL‐6, IL‐8,...
Bloodstream infections caused by Escherichia coli ST131 and H30-Rx subclones have emerged worldwide. This study was carried out to evaluate the prevalence of ST131-Rx subclone characterize virulence properties Rx isolates among bloodstream E. isolates. A total 297 non-duplicated were studied. Antibiotic susceptibilities tested using disc diffusion method. PCR amplification sequencing used identify H30-Rx, gene, β-lactamase virotype. Quinolone resistance bacteraemic strains 51 %, it 98 % The...
Abstract Background The detection rate of clinically significant prostate cancer has improved with the use multiparametric magnetic resonance imaging (mpMRI). Yet, even MRI‐guided biopsy 15%–35% high‐risk lesions (Prostate Imaging‐Reporting and Data System [PI‐RADS] 4 5) are histologically benign. It is unclear if these false positives due to diagnostic/sampling errors or pathophysiological alterations. To better understand this, we tested benign PI‐RAD 5 for common malignant epigenetic...
Abstract Preclinical tumor models with native tissue microenvironments provide essential tools to understand how heterogeneous phenotypes relate drug response. Here, we present syngeneic graft of aggressive, metastasis-prone histopathology-specific NSCLC types driven by KRAS mutation and loss LKB1 (KL): adenosquamous carcinoma (ASC) adenocarcinoma (AC). We show that subcutaneous injection primary KL-ASC cells results in squamous cell (SCC) tumors high levels stromal infiltrates, lacking the...
Preclinical tumor models with native tissue microenvironments provide essential tools to understand how heterogeneous phenotypes relate drug response. Here we present syngeneic graft of aggressive, metastasis-prone histopathology-specific NSCLC types driven by KRAS mutation and loss LKB1 (KL): adenosquamous carcinoma (ASC) adenocarcinoma (AC). We show that subcutaneous injection primary KL; ASC cells results in squamous cell (SCC) tumors high levels stromal infiltrates, lacking the source...