Thermally-robust and water-soluble Ir(<sc>i</sc>) Ir(<sc>iii</sc>) N-heterocyclic carbene complexes with sulfonate functionalized wingtips are prolific catalysts for carbonate transfer hydrogenation from glycerol without additives in aqueous media.

The acceptorless dehydrogenation of acyclic secondary amines is a highly desirable but still elusive catalytic process. Here we report the synthesis, characterization, and activity Pd-doped hydrotalcites (Pd-HTs) for both primary (cyclic acyclic). These multifunctional catalysts comprise Brønsted basic Lewis acidic surface sites that stabilize Pd in 0, 2+, 4+ oxidation states. speciation corresponding performance strong function metal loading. High observed aliphatic to imines,...

Catalytic transfer hydrogenation of CO₂ from glycerol to afford formic and lactic acid is an attractive path valorizing two waste streams. The process significantly more thermodynamically favorable than direct hydrogenation.

Replication Protein A (RPA), a single-stranded DNA (ssDNA) binding protein, is vital for various aspects of genome maintenance such as replication, recombination, repair and cell cycle checkpoint activation. Binding RPA to ssDNA protects it from degradation by cellular nucleases, prevents secondary structure formation suppresses illegitimate recombination. In our current study, we identified the acetyltransferase p300 be capable acetylating 70kDa subunit in vitro within cells. The...

Abstract Catalytic decarbonylation is an underexplored strategy for deoxygenation of biomass‐derived aldehydes owing to a lack low‐cost and robust heterogeneous catalysts that can operate in benign solvents. A family Pd‐functionalized hydrotalcites (Pd‐HTs) were synthesized, characterized, applied the furfural, 5‐hydroxymethylfurfural (HMF), aromatic aliphatic under microwave conditions. This catalytic system delivered enhanced yields turnover frequencies, even at low Pd loading (0.5 mol %)....

New atom-economical alternatives to Wittig chemistry are needed construct olefins from carbonyl compounds, but none have been developed to-date. Here we report an olefination of carbonyls via aldol-decarbonylative coupling aldehydes using robust and recyclable supported Pd catalysts, producing only CO H2O as waste. The reaction affords homocoupling aliphatic aldehydes, well heterocoupling aromatic ones. Computations provide insight into the selectivity thermodynamics reaction. tandem...

Abstract Cardiac glycosides (CGs) are bioactive compounds originally used to treat heart diseases, but recent studies have demonstrated their anticancer activity. We previously that Antiaris toxicaria 2 (AT2) possesses activity in KRAS mutated lung cancers via impinging on the DNA damage response (DDR) pathway. Toward developing this class of molecules for cancer therapy, herein we report a multistep synthetic route utilizing k‐strophanthidin as initial building block determination...

Multistep H2-free upgrading of alcohols to liquid hydrocarbons is highly desirable for producing drop-in fuel substitutes, but the limited reports this process select substrates require multiple catalysts and bases, resulting in applicability. Direct conversion processes that rely on multifunctional do not base are yet be reported. Here we describe such a Pd-catalyzed deoxygenative coupling heptanol with heterogeneous composed Pd immobilized acid–base supports, which actively participate...

Key words quinolones - heterocyclization fused heterocycles serial oxidation

ABSTRACT Replication Protein A (RPA), a single-stranded DNA (ssDNA) binding protein, is vital for various aspects of genome maintenance such as replication, recombination, repair and cell cycle checkpoint activation. Binding RPA to ssDNA protects it from degradation by cellular nucleases, prevents secondary structure formation illegitimate recombination. In our current study, we identified the acetyltransferase p300 be capable acetylating 70kDa subunit in vitro within cells. The acetylation...

&lt;p&gt;Here we report the synthesis, characterization and activity of tunable Pd-doped hydrotalcites (Pd-HTs) for decarbonylation furfural, hydroxymethylfurfural (HMF), aromatic aliphatic aldehydes under microwave conditions. The reported is a notable improvement over prior heterogeneous catalysts this process. Furfural optimized in benign solvent compatible with biomass processing - ethanol, relatively mild conditions short reaction times. HMF selectively affords excellent yields furfuryl...

Abstract Replication Protein A (RPA) is the major single-stranded DNA (ssDNA) binding protein in cell and plays a role replication, recombination, damage response (DDR) repair. RPA functions to protect ssDNA from degradation also serves as an interaction hub recruit replication DDR machinery. Under normal cellular conditions, abundance excess that of generated during S phase so fork collapse catastrophe event elevated levels stress. inhibition thus promising cancer therapeutic strategy...

The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic Lewis acidic surface sites that stabilize Pd species in 0, 2+, 4+ oxidation states. speciation corresponding cataytic performance a strong function metal loading. Excellent observed the oxidative transamination primary amines secondary to imines using low loading (0.5 mol%), without need...

&lt;div&gt; &lt;p&gt;The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic Lewis acidic surface sites that stabilize Pd species in 0, 2+, 4+ oxidation states. speciation corresponding cataytic performance a strong function metal loading. Excellent observed the oxidative transamination primary amines secondary to imines using low loading (0.5...

The synthesis, characterization, and activity of Pd-doped layered double hydroxides (Pd-LDHs) for acceptorless amine dehydrogenation is reported. These multifunctional catalysts comprise Brønsted basic Lewis acidic surface sites that stabilize Pd species in 0, 2+, 4+ oxidation states. speciation corresponding cataytic performance a strong function metal loading. Excellent observed the oxidative transamination primary amines secondary to imines using low loading (0.5 mol%), without need...

New atom-economical alternatives to Wittig chemistry are needed construct olefins from carbonyl complexes, but none have been developed to-date. Here we report an olefination of carbonyls via aldol-decarbonylative coupling aldehydes using robust and recyclable supported Pd catalysts, producing only CO H&lt;sub&gt;2&lt;/sub&gt;O as waste. The reaction accommodates homocoupling with a a-methylene groups, well heterocoupling. Computations provide insight into the selectivity reaction. tandem...

New atom-economical alternatives to Wittig chemistry are needed construct olefins from carbonyl complexes, but none have been developed to-date. Here we report an olefination of carbonyls via aldol-decarbonylative coupling aldehydes using robust and recyclable supported Pd catalysts, producing only CO H 2 O as waste. The reaction accommodates homocoupling with a a-methylene groups, well heterocoupling. Computations provide insight into the selectivity reaction. tandem aldol-decarbonylation...

Here we report the synthesis, characterization and activity of tunable Pd-doped hydrotalcites (Pd-HTs) for decarbonylation furfural, hydroxymethylfurfural (HMF), aromatic aliphatic aldehydes under microwave conditions. The reported is a notable improvement over prior heterogeneous catalysts this process. Furfural optimized in benign solvent compatible with biomass processing - ethanol, relatively mild conditions short reaction times. HMF selectively affords excellent yields furfuryl alcohol...

The Cover Feature shows the atom- and energy-efficient continuous production of biomass-derived platform chemicals over Pd/hydrotalcite bifunctional catalysts. More information can be found in Full Paper by N. An et al on page 312 Issue 2, 2020 (DOI: 10.1002/cssc.201901934).

Abstract Cardiac Glycosides (CGs) are used to treat congestive heart disease. Their application has since been extended cancer treatment. While the mechanism of action is still unknown, it was previously believed that Na+/K+ ATPase might play a crucial role in mitigation. However, we recently reported cardiac glycosides could specifically enhance anti-cancer effect chemotherapy KRAS mutant lung by inhibiting DNA Damage Response (DDR), and these effects were independent ATPase....

Design of active and selective supported catalysts is critical for developing new tandem processes upgrading biomass-derived alcohols. Hydrogen-free alcohols to liquid hydrocarbons desirable producing drop-in fuel substitutes, but direct atom-economical are yet be reported. Here we report a novel alcohol deoxygenation cascade that meets these criteria. This hydrogen-free catalyzed by multifunctional Pd catalysts, whose supports feature range acid-base properties: primarily basic MgO, acidic...

&lt;p&gt;Design of active and selective supported catalysts is critical for developing new tandem processes upgrading biomass-derived alcohols. Hydrogen-free alcohols to liquid hydrocarbons desirable producing drop-in fuel substitutes, but direct atom-economical are yet be reported. Here we report a novel alcohol and&lt;b&gt; &lt;/b&gt;deoxygenation cascade that meets these criteria. This hydrogen-free catalyzed by multifunctional Pd catalysts, whose supports feature range acid-base...