A5062349813- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- Air Quality and Health Impacts
- Nanoplatforms for cancer theranostics
- Inhalation and Respiratory Drug Delivery
- Plasmonic and Surface Plasmon Research
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Neonatal Respiratory Health Research
- Nanotechnology research and applications
- Sulfur Compounds in Biology
- Graphene and Nanomaterials Applications
- Lipid Membrane Structure and Behavior
- Mass Spectrometry Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Luminescence Properties of Advanced Materials
- Extracellular vesicles in disease
- Transition Metal Oxide Nanomaterials
- Adenosine and Purinergic Signaling
- Advanced Battery Materials and Technologies
- Polydiacetylene-based materials and applications
- Neuroscience and Neural Engineering
University of Cyprus
2019-2023
Imperial College London
2013-2020
London Centre for Nanotechnology
2013-2020
Imperial Valley College
2020
South West London and St George's Mental Health NHS Trust
2020
Transnational Press London
2015-2016
Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining effect of AgNP on resident immune cells brain, microglia. Given microglia implicated neurodegenerative disorders such as Parkinson's disease (PD), it important examine how AgNPs affect microglial inflammation fully assess neurotoxicity. In addition, understanding processing by will allow better prediction their long term bioreactivity. present study,...
Gold nanostars (AuNSs) are receiving increasing attention for their potential applications in bionanotechnology because of unique optical properties related to complex branched morphology. Their sharp features allow strong localized surface plasmon resonances, tunable the near-infrared (NIR) region, and large enhancements local electromagnetic fields. Here, application AuNSs metal-enhanced fluorescence (MEF) NIR second (NIR-II) biological windows is explored first time. NIR/NIR-II...
Silver nanowires (AgNWs) are being developed for use in optoelectronics. However before widespread usage, it is crucial to determine their potential effects on human health. It accepted that Ag nanoparticles (AgNPs) exert toxic by releasing Ag+ ions, but much less known about whether reacts with compounds, or any downstream bioactive of transformed AgNPs. Analytical high-resolution transmission electron microscopy has been employed elucidate cellular uptake and reactivity AgNWs inside...
Bacterial infections of the pulmonary system are increasing.
ZnO nanoparticles (NPs) are reported to show a high degree of cancer cell selectivity with potential use in imaging and therapy. Questions remain about the mode by which NPs cause death, whether they exert an intra‐ or extracellular effect, resistance among different types NP exposure. The present study quantifies variability between cellular toxicity, dynamics uptake, dissolution bare RGD (Arg‐Gly‐Asp)‐targeted MDA‐MB‐231 cells. Compared NPs, RGD‐targeting integrin αvβ3 receptors expressed...
There is a need for novel strategies to treat aggressive breast cancer subtypes and overcome drug resistance.
Inhaled nanoparticles (NPs) have high-deposition rates in the alveolar region of lung but effects pulmonary surfactant (PS) on nanoparticle bioreactivity are unclear. Here, impact PS stability and dissolution ZnO nanowires (ZnONWs) was investigated, linked with their vitro human epithelial type 1-like cells (TT1). Pre-incubation ZnONWs Curosurf® (a natural porcine PS) decreased at acidic pH, through formation a phospholipid corona. Confocal live cell microscopy confirmed that lowered...
Single-particle metal enhanced fluorescence from colloidal gold nanostars (AuNSs) enables super bright biologically relevant near-infrared fluorophores.
Au nanodisc arrays with nanoscale control of their structural characteristics, allow significant NIR fluorescence enhancement tunable sensitivities.
The amplification of light in NIR-II from Ag2S QDs via metal enhanced fluorescence (MEF) is reported for the first time. Significant enhancement over 100 times deposited on Au-nanostructured arrays, paves way novel sensing and imaging applications based QDs, with improved detection sensitivity contrast enhancement.
Gold nanostars increase the brightness of weakly-emitting dyes in near-infrared biological window for cellular imaging with tunable enhancement factors.
Metal-enhanced fluorescence (MEF), resulting from the near-field interaction of fluorophores with metallic nanostructures, has emerged as a powerful tool for dramatically improving performance fluorescence-based biomedical applications. Allowing lower autofluorescence and minimal photoinduced damage, development multifunctional multiplexed MEF platforms in near-infrared (NIR) windows is particularly desirable. Here, low-cost fabrication method based on nanosphere lithography applied to...
There is a growing concern about the potential adverse effects on human health upon exposure to engineered silver nanomaterials (particles, wires, and plates). However, majority of studies testing toxicity have examined nominally "as-synthesized" materials without considering fate in biologically relevant fluids. Here, in-house nanowires (AgNWs) were prepared by modified polyol process incubated three cell culture media (DMEM, RPMI-1640, DCCM-1) examine impact AgNW-medium interactions...
Lung alveolar secretions block Ag nanowire reactivity.
Abstract Plasmonic gold (Au) nanotriangular arrays, functionalized with a near infrared (NIR) fluorophore-conjugated immunoassay to Carbohydrate Antigen 19-9 (CA 19-9), pancreatic cancer biomarker, produce optically tunable substrates two orders of magnitude fluorescence enhancement. Through nanoscale morphological control, the sensitivities plasmonic arrays are controllable, paving way such optical platforms for multiplexing. Here, we report limit detection (LOD) 7.7 × 10 −7 U.mL −1 CA 19–9...
There is a potential for silver nanowires (AgNWs) to be inhaled, but there little information on their health effects and chemical transformation inside the lungs in vivo. We studied of short (S-AgNWs; 1.5 μm) long (L-AgNWs; 10 instilled into Sprague-Dawley rats. S- L-AgNWs were phagocytosed degraded by macrophages; was no frustrated phagocytosis. Interestingly, both AgNWs internalized alveolar epithelial cells, with precipitation Ag2S surface as secondary nanoparticles. Quantitative serial...
Silver nanowires (AgNWs) are increasingly being used in the production of optoelectronic devices, with manufacturing processes posing a risk for occupational exposures via inhalation. Although some studies have explored environmental effects AgNWs, few data exist on human health effects. Alveolar macrophages central clearance inhaled fibers from lungs, frustrated phagocytosis often stated as key determinant onset inflammatory reactions. However, mechanisms through which fully ingested AgNWs...
The increase of production volumes silver nanowires (AgNWs) and consumer products incorporating them may lead to increased health risks from occupational public exposures. There is currently limited information about the putative toxicity AgNWs upon inhalation incomplete understanding properties that control their bioreactivity. lung lining fluid (LLF), which contains phospholipids surfactant proteins, represents a first contact site with respiratory system. In this work, impact...
The lithium storage properties of the distorted metal-organic framework-derived nanosized ZnO@C are significantly improved by introduction Ag2S quantum dots (QDs) during processing material. In thermal treatment, QDs react to produce Ag nanoparticles and ZnS. metal act shorten electron pathways improve connectivity matrix, partial sulfidation ZnO surface improves cycling stability electrochemical ZnO@C, QDs-treated amorphous carbon in have been compared. small weight ratio at 1:180 shows...
Efficient enhancement of photoluminescence in rare-earth activated upconversion materials is great significance for their practical applications various fields. In this work, three-dimensional mesoporous gold films were fabricated by a low-cost and facile dealloying approach to improve the efficiency. The Au exhibit good chemical stability, large-area uniformity abundant distribution porous nanospaces. Varying time process leads modification pore size distribution, surface roughness residual...
There are no methods sensitive enough to detect enzymes within cells, without the use of analyte labeling. Here we show that it is possible protein ion signals three different H2S-synthesizing inside microglia after pretreatment with silver nanowires (AgNW) using time-of-flight secondary mass spectrometry (TOF-SIMS). Protein fragment ions, including amino acid (C4H8N+ = 70 amu), fragments sulfur-producing cystathionine-containing enzymes, and Ag+ signal could be detected any labels; cells...
There is an imminent need for novel strategies the diagnosis and treatment of aggressive triple-negative breast cancer (TNBC). Cell-targeted multifunctional nanomaterials hold great potential, as they can combine precise early-stage with local therapeutic delivery to specific cell types. In this study, we used mesoporous silica (MS)-coated gold nanobipyramids (MS-AuNBPs) fluorescence imaging in near-infrared (NIR) biological window, along targeted TNBC treatment. Our MS-AuNBPs, acting partly...
Background: The toxicity of inhaled silver nanoparticles on contractile and pro-inflammatory airway smooth muscle cells (ASMCs) that control calibre is unknown. We explored the oxidative activities sulfidation processes toxic-inflammatory response. Method: Silver nanospheres (AgNSs) 20 nm 50 diameter nanowires (AgNWs), short S-AgNWs, 1.5 μm long L-AgNWs, 10 μm, both 72 in were manufactured. measured their effects cell proliferation, mitochondrial reactive oxygen species (ROS) release...
On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows that NPs dissolve into ionic Zn2+ (blue) upon uptake cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy therapy. Cover design by Ivan Gromicho.