A5052211098- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Electrolyte and hormonal disorders
- Chronic Kidney Disease and Diabetes
- Cardiac Arrhythmias and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Prostate Cancer Treatment and Research
- Diabetes Treatment and Management
- Acute Ischemic Stroke Management
- Cardiovascular Function and Risk Factors
- PARP inhibition in cancer therapy
- Cardiac Imaging and Diagnostics
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Dialysis and Renal Disease Management
- Membrane-based Ion Separation Techniques
- Dementia and Cognitive Impairment Research
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Parathyroid Disorders and Treatments
- Magnesium in Health and Disease
Janssen (Switzerland)
2023-2025
Cilag (Switzerland)
2024
Karolinska Institutet
2017-2022
Baxter (Sweden)
2017-2021
Karolinska University Hospital
2021
Institute for Medical Informatics and Biostatistics
2019
Neuroscience Institute
2018
University of Turin
2018
University of Milano-Bicocca
2018
Thrombolysis in Myocardial Infarction Study Group
2016-2017
BackgroundAlthough germline BRCA mutations have been associated with adverse outcomes in prostate cancer (PC), understanding of the association between somatic/germline alterations homologous recombination repair (HRR) genes and treatment metastatic castration-resistant PC (mCRPC) is limited.The aim this study was to investigate prevalence HRR alterations, particularly BRCA1/2, patients initiating first-line (1L) mCRPC androgen receptor signalling inhibitors (ARSi) or taxanes.Patients...
Background Concerns for hyperkalaemia limit the use of mineralocorticoid receptor antagonists (MRAs). The frequency MRA‐associated in real‐world settings and extent subsequent MRA discontinuation are poorly quantified. Methods results Observational study including all Stockholm citizens initiating therapy during 2007–2010. Hyperkalaemias were identified from potassium (K + ) measurements healthcare. treatment lengths dosages obtained complete collection pharmacy dispensations. We assessed...
The use of non-vitamin K antagonist oral anticoagulants (NOACs) instead vitamin antagonists (VKAs) in patients with atrial fibrillation (AF) and coexisting valvular heart disease (VHD) is substantial interest. This study explored outcomes AF without VHD the ENGAGE AF–TIMI 48 (Effective Anticoagulation factor Xa Next Generation Atrial Fibrillation-Thrombolysis In Myocardial Infarction 48) trial, comparing edoxaban warfarin. Valvular was defined as history or baseline echocardiography evidence...
Community-based reports regarding the association between estimated glomerular filtration rate (eGFR) and dementia risk show conflicting results. The aim of this study is to investigate links among kidney function, function decline, incidence.We analyzed eGFR with (defined as a new diagnosis or initiation treatments) 329,822 residents Stockholm who accessed health care during 2006 2011, were ≥65 years age, had no history dementia, underwent replacement therapy. We also decline 205,622...
Despite long-standing clinical use of sodium polystyrene sulphonate (SPS) for hyperkalaemia management in chronic kidney disease (CKD), its safety profile remains poorly investigated.
Community-based reports regarding eGFR and the risk of cancer are conflicting. We here explore plausible links between kidney function incidence in a large Scandinavian population-based cohort.In Stockholm Creatinine Measurements project, we quantified associations baseline with among 719,033 Swedes ages ≥40 years old no prior history cancer. Study outcomes were any type site-specific rates on basis International Classification Diseases-10 codes over median follow-up 5 years. To possibility...
It has been suggested that lung function can be altered by both free radical and oxidant exposure, while antioxidant vitamin intake is positively related to function. However, the information on relation of blood levels oxidants antioxidants sparse. The present cross-sectional study, conducted from September 1995 May 1996, analyzes association between measured as forced expiratory volume in 1 second (FEV1 with 1) thiobarbituric acid-reactive substances plasma (p-TBARS) low very density...
Background and objectives Patients with CKD have a high risk of atrial fibrillation. Both fibrillation are associated higher stroke death. However, the effect incident on among patients is unknown. Design, setting, participants, & measurements Our study included adults (eGFR<60 ml/min per 1.73 m 2 ) without previously documented who had been in contact health care Stockholm, Sweden during 2006–2011. Incident was identified by administrative diagnostic codes outpatient or inpatient...
Spinal muscular atrophy (SMA) is a pediatric genetic disease, characterized by motor neuron (MN) death, leading to progressive muscle weakness, respiratory failure, and, in the most severe cases, death. Abnormalities at neuromuscular junction (NMJ) have been reported SMA, including neurofilament (NF) accumulation presynaptic terminals, immature and smaller than normal endplates, reduced transmitter release, finally, denervation. Here we studied role of agrin SMAΔ7 mice, experimental model...
Stopping renin-angiotensin system inhibitors (RASi) after an episode of hyperkalemia is common but may involve therapeutic compromises, in that the cessation RASi deprives patients their beneficial cardiovascular effects.Observational study from Stockholm Creatinine Measurements (SCREAM) project including initiating routine care and surviving a first-detected (potassium >5.0 mmol/L). We used target trial emulation techniques based on cloning, censoring weighting to compare stopping vs....
5003 Background: Understanding of the association between HRR mutations and outcomes in mCRPC pts is limited. This analysis investigated prevalence with/out (somatic and/or germline), stratified as BRCA, non-BRCA, or who initiated 1L treatment with novel hormonal therapy (NHT) taxane. Methods: Eligible from PROREPAIR-B (NCT03075735), PROSENZA (NCT02922218), PROSTAC (NCT02362620), PROSABI (NCT02787837) studies underwent paired somatic/germline DNA analyses using a custom NGS panel that...
The choice between initiating a non-vitamin K antagonist oral anticoagulant (NOAC) and vitamin (VKA) in patients with atrial fibrillation (AF) may be challenging. To assist this decision, we developed risk score to identify for whom therapeutic benefit of NOACs over VKA is predicted. ENGAGE AF-TIMI 48 was randomized clinical trial edoxaban vs. warfarin 21 105 AF. Cox proportional hazard models identified factors associated serious net outcome (NCO) disabling stroke, life-threatening...
Trial evidence indicates that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may reduce the risk of cardiovascular (CV) events in patients with diabetes and myocardial infarction (MI). We aimed to expand this observation routine care settings.Prospective observational study including all surviving an MI registered nationwide SWEDEHEART registry during 2010-17. Multivariable Cox regression analyses were used estimate association between GLP-1 RAs use outcome, which was a composite...
The increasing prevalence of ischaemic stroke (IS) can partly be explained by the likewise growing number patients with chronic kidney disease (CKD). Risk scores have been developed to identify high-risk patients, allowing for personalized anticoagulation therapy. However, predictive performance in CKD is unclear. aim this study validate six commonly used risk IS atrial fibrillation (AF) across spectrum function.Overall, 36 004 subjects newly diagnosed AF from SCREAM (Stockholm CREAtinine...
In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, multi-organ failure, and death. We previously demonstrated that alpha-1 adrenergic receptor (⍺
Background and objectives Data from observational interventional studies provide discordant results regarding the relationship between creatinine increase after renin-angiotensin system inhibition (RASi) adverse outcomes. We compared health outcomes among patients with different categories of in upon initiation RASi a large population-based cohort. Design, setting, participants, & measurements performed retrospective analysis Stockholm CREAtinine Measurements database, which contains...