Carly Botheras
A5046336977- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Patient Satisfaction in Healthcare
- Antifungal resistance and susceptibility
- Healthcare Systems and Technology
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
Barwon Health
2023
Deakin University
2021-2023
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials treatments for SAB infection. The limited evidence base partly results from infections being difficult to complete at scale using traditional trial methods. Here we provide the rationale framework an adaptive platform applied infections. We detail design features Network Adaptive Platform (SNAP)...
Abstract Background Staphylococcus aureus (S. aureus) bacteraemia is increasingly acquired from community settings and associated with a mortality rate of up to 40% following complications. Identifying risk factors for complicated S. would aid clinicians in targeting patients that benefit expedited investigations escalated care. Methods In this prospective observational cohort study, we aimed identify infection community-onset bacteraemia. Potential were collected electronic medical records...
Abstract Objectives There is clinical uncertainty over the optimal treatment for penicillin-susceptible Staphylococcus aureus (PSSA) infections. Furthermore, there concern that phenotypic penicillin susceptibility testing methods are not reliably able to detect some blaZ-positive S. aureus. Methods Nine isolates, including six genetically diverse strains harbouring blaZ, were sent in triplicate 34 participating laboratories from Australia (n = 14), New Zealand 6), Canada 12), Singapore 1)...