A5102002763- CAR-T cell therapy research
- X-ray Diffraction in Crystallography
- Lung Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Global Cancer Incidence and Screening
- Crystallization and Solubility Studies
- Metastasis and carcinoma case studies
- Blood transfusion and management
- Lung Cancer Treatments and Mutations
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cancer Immunotherapy and Biomarkers
- Air Quality and Health Impacts
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Medical Malpractice and Liability Issues
- Radiomics and Machine Learning in Medical Imaging
- Ubiquitin and proteasome pathways
- Global Health Care Issues
- Cancer Risks and Factors
- Immunotherapy and Immune Responses
- Metal-Organic Frameworks: Synthesis and Applications
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Colorectal Cancer Screening and Detection
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Gilead Sciences (France)
2024
Peking Union Medical College Hospital
2023-2024
Peking University People's Hospital
2024
Peking University
2024
Academy of Medical Sciences
2024
Suizhou Central Hospital
2024
Guangdong Medical College
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2022-2023
Kite (United States)
2022
Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell therapy approved for relapsed/refractory large B lymphoma (LBCL) and has treatment with similar efficacy across conventional LBCL subtypes. Toward patient stratification, we assessed whether tumor immune contexture influenced clinical outcomes after axi-cel. We evaluated the microenvironment (TME) of 135 pre-treatment post-treatment biopsies taken from 51 patients in ZUMA-1 phase 2 trial. uncovered...
Objective To project future trajectories of the gastric cancer (GC) burden in China under different scenarios GC prevention and identify strategies to improve affordability cost-effectiveness. Design Using a cohort Chinese men women born during 1951–1980, we assumed that were conducted, including eradication Helicobacter pylori (Hp) endoscopy screening (one-time, annual, biennial, triennial or stratified according personal risk). We performed literature search up-to-date data populate Markov...
A major goal in genomic research is to identify genes that may jointly influence a biological response. From many years of intensive biomedical research, large body knowledge, or pathway information, has accumulated available databases. There strong interest leveraging these pathways improve the statistical power and interpretability studying gene networks associated with complex phenotypes. This prior information valuable complement large-scale data such as expression generated from...
Background Endothelial dysfunction is associated with two main complications of chimeric antigen receptor T (CAR-T) cell therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS). This study evaluates the Activation Stress Index (EASIX) as a prognostic marker for high-grade CRS ICANS in patients treated CD19-directed CAR-T cells. Methods In this retrospective study, training cohort 93 from ZUMA-1 trial validation 121 independent centers (University...
Abstract Background Cancer has become a global health problem, and assessments of cancer mortality are important for effective public policy‐making adequate resource allocation. In this study, we aimed to predict the rates numbers deaths related four common cancers (lung, liver, stomach, esophagus) in China from 2020 2030 estimate corresponding burden caused by population aging tobacco smoking. Methods data (2004–2017) were extracted China's death surveillance datasets, figures (2020–2030)...
To estimate the long-term effect of changing demography in China on blood supply and demand.We developed a predictive model to demand during 2017-2036 mainland 31 province-level regions. Model parameters were obtained from World Population Prospects, statistical yearbook 2016, China's report safety records large tertiary hospital. Our main assumptions stable age-specific per capita over time.We estimated that change demographic structure between 2016 (baseline year) 2036 would result 16.0%...
Surface water pollution and digestive cancers are concerning environmental health issues. Multiple pollutants of surface coexist within unique geospatial heterogeneous contexts flow, which can lead to complex patterns impact on cancer incidence. This complexity has posed challenges comprehensive assessment. In this study, we integrated nationwide data 21 collected from 3632 sections nine large river basins incidence for six covering 381.6 million people in China. Local Moran's I method was...
Recent advancements in robot tool use have unlocked their usage for novel tasks, yet the predominant focus is on rigid-body tools, while investigation of soft-body tools and dynamic interaction with rigid bodies remains unexplored. This paper takes a pioneering step towards one-shot soft manipulating objects, challenging problem posed by complex interactions unobservable physical properties. To address these problems, we propose Implicit Physics-aware (IPA) policy, designed to facilitate...
Hypomagnesemia has been correlated with inferior outcomes in patients large B cell lymphoma (LBCL) undergoing stem transplants. As T-cell and myeloid dysfunction have associated low magnesium conditions, we investigated whether serum (Mg) levels could predict clinical LBCL who received chimeric antigen receptor therapy. Patients axi-cel under the ZUMA-1 trial or as FDA approved therapy at Mayo Clinic were examined. Serum samples obtained specified time points cytokine analysis was performed....
Mortality outcomes in trials of low-dose computed tomography (CT) screening for lung cancer are inconsistent. This study aimed to evaluate whether CT urban areas China could reduce mortality and investigate the factors that associate with effect. A decision tree model three scenarios (low-dose screening, chest X-ray no screening) was developed compare results a simulated Chinese cohort (100,000 smokers aged 45–80 years). Data participant characteristics were obtained from national registries...
Background A relationship of blood uric acid (UA) with hypertension and cardiovascular risk is under debate thus salt intake hypothesized to contribute such associations. Methods In this cross-sectional study, stratified cluster random sampling elicited a sample 1805 Kazakhs 92.4% compliance. Hypertension moderate-or-high total (mTCR) were defined according guidelines. Sodium was assessed by urinary sodium excretion. Prevalence ratios (PRs) used express associations UA mTCR. Results the...
Objective: China is a developing country with urban–rural disparities and accelerating population aging. Therefore, quantifying the effects of aging on cancer mortality burden urgently needed. Methods: Using data from China’s death surveillance datasets (2004–2017), we decomposed quantified factor variations rates in urban rural during 2004–2017 through decomposition method. R ratios were used to assess extent decreases attributable offsetting increases for 4 aging-related cancers (lung,...
Abstract Little is known about the association between surface water quality and cancer incidence, especially in China. Drinking has been linked to incidence of several cancers individual-level studies. However, few studies have attempted examine multiple pollutants at population level. This study used monitoring population-level data from across China spatial associations types cancer. We found a “dose–response” relationship number present high levels incidence. These results provide...
Smoking increases the risk of numerous cancers; however, an association smoking with adult gliomas has not been found in a population. This case-control study included 4556 glioma cases (ICD-9 code 191.0–191.9) aged ≥30 years and 9112 controls from national survey mortality China 1989–1991. Controls 325 255 surviving spouses all-cause deaths were randomly assigned to each 103 areas according sex age groups at ratio 2:1. information was ascertained retrospectively by interviewing spouses....
Abstract An association between passive smoking and stroke is unclear in China, particularly the with hemorrhagic stroke. This study included 16205 deaths due to aged ≥30 years non-stroke controls randomly selected frequency-matched cases on gender age. Smoking of spouses, defined as ≥1 cigarette per day for up 1 year, was taken a measure exposure subjects that retrospectively ascertained by interviewing surviving spouses. After adjustment variables, increased risk death 10% (odds ratio...