A5103101526- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- RNA modifications and cancer
- Curcumin's Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Kruppel-like factors research
- TGF-β signaling in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Image Analysis Techniques
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Biosensors and Analytical Detection
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- SARS-CoV-2 detection and testing
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Wnt/β-catenin signaling in development and cancer
- Biomarkers in Disease Mechanisms
- RNA and protein synthesis mechanisms
Tarbiat Modares University
2015-2025
Shahid Beheshti University of Medical Sciences
2021
Kowsar Hospital
2021
Abstract Background Among the approximately 8000 Mendelian disorders, >1000 have cutaneous manifestations. In many of these conditions, underlying mutated genes been identified by DNA-based techniques which, however, can overlook certain types mutations, such as exonic-synonymous and deep-intronic sequence variants. Whole-transcriptome sequencing RNA (RNA-seq) identify mutations provide information about their consequences. Methods We analyzed whole transcriptome 40 families with...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), characterized by neuroinflammation, oligodendrocytes (OLs) loss, and demyelination Curcumin, natural phenolic substance, has been shown to have significant therapeutic properties in various neurodegenerative diseases, including MS. In our laboratory loading curcumin dendrosome nanoparticles we improved its solubility bioavailability. Our previous study showed anti-inflammatory anti-oxidative effects...
The authors declare no conflict of interest.
microRNAs (miRNAs or miRs) play key roles in different stages of chronic myeloid leukemia (CML) pathogenesis. The present study aimed to demonstrate whether miR-155 enables CD34+ CML cells escape from the growth-inhibitory effects TGF-β1 and bone morphogenetic protein (BMP) signaling. Among differentially expressed miRNAs cells, was highly up-regulated. QRT-PCR revealed an inverse correlation between two members TGF-β pathway-TGF-βR2 SMAD5. Results showed that SMAD5 is not only up-regulated...
Background: Megakaryopoiesis is characterized by progressive polyploidization and the expression of megakaryocytic markers. Numerous transcription factors physiological signaling pathways regulate this phenomenon. Megakaryocyte differentiation induction in K562 cell line hematopoietic stem cells via nanocurcumin drug has been identified our previous study. are typical Chronic Myelogenous Leukemia (CML) that resistant to apoptosis express bcr-abl fusion gene. These have potential...
Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as key factor gaining cancer stem (CSC) features and tumor aggressiveness. This study aimed evaluate expression patterns clinical significance RCC impact its targeting on cell/mesenchymal cells EMT characteristics renal spheroid derived (SDCs) compared parental (PCs) RCC. The...
Breast cancer is recognized as a major clinical challenge in gynecological diseases worldwide. Exosomes are small vesicles derived from multicellular bodies that secreted by many cells into the extracellular environment and thus participate intercellular communication through transfer of genetic information such encoded non-encoded RNAs to target cells. Tumor-derived exosomes thought be rich source microRNAs (miRs) can regulate function other tumor microenvironment. However, exact mechanisms...
Exosomes are extracellular endosomal nanoparticles, which formed under complex processes during the formation of multivesicular bodies. They also achieved from conditioned media a variety cell types, especially mesenchymal stem cells (MSCs). can modulate intracellular physiological actions via signaling molecules on surface or secretion components to spaces. Furthermore, they potentially used as crucial agents for cell-free therapy; however, their isolation and characterization be...
Abstract Background SARS-Cov-2 is a new virus that caused an epidemic disease, COVID-19. According to the world health organization, detecting patients/carriers by far most important action prevent pandemic. Recently, loop-mediated isothermal amplification (LAMP) technique has become more popular due easy handling of one-step kit used for detection many diseases than RT-PCR-based techniques. methods Herein, we RT-LAMP so as detect To this end, 40 paired-samples patients and healthy people...