A5057130605- Cancer Research and Treatments
- Bacteriophages and microbial interactions
- Gut microbiota and health
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Microbial Metabolites in Food Biotechnology
- Ubiquitin and proteasome pathways
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diet and metabolism studies
- Nanoplatforms for cancer theranostics
- Bacterial biofilms and quorum sensing
- Biochemical Analysis and Sensing Techniques
- Probiotics and Fermented Foods
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Cancer therapeutics and mechanisms
- Antibiotic Resistance in Bacteria
- Animal Genetics and Reproduction
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Enzyme Catalysis and Immobilization
- Tissue Engineering and Regenerative Medicine
National University of Singapore
2017-2025
University of Birmingham
2017
Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for brain-targeted therapeutic delivery, although its feasibility is hampered by anatomical and absorptive limitations of OE. In this study, we identified Lactobacillus plantarum WCFS1 (Lp), commensal strain with natural affinity OE engineered it to function as vector cerebral drug delivery. Upon intranasal administration, Lp released specific payload molecules within OE, subsequent transport...
Abstract Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serve tumor-targeting vectors for delivering prodrugs. In this study, we harness bacteria-cancer interactions native the microbiome achieve high prodrug delivery. We identify oral commensal strain Lactobacillus plantarum with intrinsic cancer-binding mechanism and engineer enable...
Abstract Synthetic biology research and technology translation has garnered increasing interest from the governments private investors in Asia, where great potential driving a sustainable bio‐based economy. This Perspective reviews latest developments key enabling technologies of synthetic its application bio‐manufacturing, medicine, food agriculture Asia. Asia‐centric strengths to grow economy, such as advances genome editing presence biofoundries combined with availability natural...
The EvgS/EvgA two-component system of Escherichia coli is activated in response to low pH and alkali metals regulates many genes, including those for the glutamate-dependent acid resistance a number efflux pumps. EvgS, sensor kinase, one five unconventional histidine kinases (HKs) E. has large periplasmic domain cytoplasmic PAS addition phospho-acceptor, HK dimerization, internal receiver, phosphotransfer domains. Mutations that constitutively activate protein at 7 map domain. Here, we built...
Nucleic acid detection is crucial for monitoring diseases which rapid, sensitive, and easy-to-deploy diagnostic tools are needed. CRISPR-based technologies can potentially fulfill this need nucleic detection. However, their widespread use has been restricted by the requirement of a protospacer adjacent motif in target extensive guide RNA optimization. In study, we developed FELICX, technique that overcome these limitations provide useful alternative to existing technologies. FELICX comprises...