A5006652992- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Organometallic Complex Synthesis and Catalysis
- Diabetes Treatment and Management
- Synthesis and Catalytic Reactions
- Pancreatic function and diabetes
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Axial and Atropisomeric Chirality Synthesis
- Microbial Natural Products and Biosynthesis
- Laser Applications in Dentistry and Medicine
- Synthesis of heterocyclic compounds
- Synthetic Organic Chemistry Methods
- Plant and Fungal Interactions Research
- Dental Implant Techniques and Outcomes
- Chemical Reaction Mechanisms
- Endodontics and Root Canal Treatments
- Coordination Chemistry and Organometallics
- Periodontal Regeneration and Treatments
- Advanced Synthetic Organic Chemistry
Hebei University
2025
Shaanxi Normal University
2023-2024
Central China Normal University
2019
Wuxi Third People's Hospital
2012-2019
Wuxi Fourth People's Hospital
2019
Amgen (United States)
2011-2015
Nankai University
1999-2015
Hebei Food Inspection and Research Institute
2015
Henan Institute of Science and Technology
2014
Division of Chemistry
2011
In this paper, we demonstrate the first examples of chiral Lewis acid catalysis in formation tetrahydro-1,2-oxazines with very high enantioselectivity starting diactivated cyclopropanes and nitrones (>90% yields ee). Reactions racemic substituted provide ∼1:1 diastereomeric tetrahydro-1,2-oxazine products enantioselectivity. Mechanistic information for is also detailed.
Abstract Herein, we present a unified chemical synthesis of three subgroups cephalotaxus diterpenoids. Key to the success lies in adopting synthetic strategy that is inspired by biosynthesis but opposite nature. By employing selective one‐carbon introduction and ring expansion operations, have successfully converted cephalotane‐type C 18 dinorditerpenoids (using cephanolide B as starting material) into troponoid‐type 19 norditerpenoids intact 20 This approach has enabled us synthesize...
We have developed a novel method for accessing exo adducts with high enantioselectivity in nitrone cycloadditions to enoates. Pyrazolidinones proved be effective achiral templates the cycloadditions, providing typically >15:1 selectivity and 90-98% ee. The use of Lewis acids that form square planar complexes, such as copper triflate, was important obtaining selectivity.
Catalytic asymmetric sulfur ylide [2,3]-sigmatropic rearrangement of carbenoids generated from aryldiazoacetates has been investigated with a number chiral Rh(II) and Cu(I) catalysts, moderately high enantioselectivity (52-78% ee) can be achieved Cu(MeCN)(4)PF(6)/2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline].
Fatty acid amide hydrolase (FAAH), an amidase-signature family member, is integral membrane enzyme that degrades lipid amides including the endogenous cannabinoid anandamide and sleep-inducing molecule oleamide. Both genetic knock out pharmacological administration of FAAH inhibitors in rodent models result analgesic, anxiolytic, antiinflammatory phenotypes. Targeting activity, therefore, presents a promising new therapeutic strategy for treatment pain other neurological-related or...
GPR40 (FFA1 and FFAR1) has gained significant interest as a target for the treatment of type 2 diabetes. TAK-875 (1), agonist, lowered hemoglobin A1c (HbA1c) both postprandial fasting blood glucose levels in diabetic patients phase II clinical trials. We optimized phenylpropanoic acid derivatives agonists identified AMG 837 (2) candidate. Here we report our efforts searching structurally distinct back-ups 837. These led to identification more polar agonists, such AM-4668 (10), that have...
A series of β-(N-tosyl)amino diazo carbonyl compounds have been prepared by nucleophilic condensation N-tosylimines with acyldiazomethanes. The decomposition these under various catalytic conditions, including Rh(II) carboxylates, Cu(I) and Cu(II) complexes, PhCO2Ag/Et3N, TsOH, SnCl2·2H2O, has investigated. It was found that, in most cases, the gave preferentially 1,2-aryl migration product, but 1,2-hydride predominated when PhCO2Ag/Et3N system. Hammett correlation applied analysis...
[reaction: see text] The use of N-H imide templates provides a solution to the problem rotamer control in Lewis acid catalyzed reactions alpha,beta-disubstituted acryloyl imides. Reactions proceed through s-cis and with improved reactivity because A(1,3) strain is avoided. Enantioselective nitrone, nitrile oxide, Diels-Alder cycloadditions demonstrate principle.
Abstract Herein, we present a unified chemical synthesis of three subgroups cephalotaxus diterpenoids. Key to the success lies in adopting synthetic strategy that is inspired by biosynthesis but opposite nature. By employing selective one‐carbon introduction and ring expansion operations, have successfully converted cephalotane‐type C 18 dinorditerpenoids (using cephanolide B as starting material) into troponoid‐type 19 norditerpenoids intact 20 This approach has enabled us synthesize...
The hybrid two-step (evaporation-spin coating) fabrication method demonstrates substantial promise for achieving conformal perovskite growth on highly textured surfaces, such as industrially silicon heterojunction (SHJ) substrates with pyramidal features...
Abstract The performance and stability of wide‐band‐gap (1.68 eV) perovskite solar cells (PSCs) are critically constrained by two main challenges: i) nonradiative recombination ii) insufficient environmental stability. In this study, a chemical synergistic passivation strategy is presented, which combines oleic acid (OA) with phenylethylammonium iodide (PEAI). neutralization reaction between OA PEAI forms amide groups (─CONH), giving the new passivator (O‐PEAI) high dissociation constant (...
In the presence of an Evans oxazolidinone as chiral auxiliary, anion derived from α-diazoacetamide adds to aromatic N-tosylimines with high stereoselectivity (see scheme). The addition products can be used in a concise and stereoselective synthesis syn- anti-α-hydroxy-β-amino acid derivatives. Supporting information for this article is available on WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z460730_s.pdf or author. Please note: publisher not responsible content functionality any...
Metalla-analogues of polycyclic aromatic hydrocarbons (PAHs) have captivated chemists with their fascinating structures and unique electronic properties. To date, metallabenzene, metallanaphthalene metallaanthracene been reported. more complicated fused rings rarely Herein, we successfully synthesized a series new iridafluoranthenes fused-ring ranging from pentacyclic to heptacyclic metallaaromatic in high yields under mild reaction conditions for the first time. Their photophysical redox...
Abstract Herein, we report a concise and divergent synthesis of the complex hasubanan alkaloids metaphanine oxoepistephamiersine from commercially available inexpensive cyclohexanedione monoethylene acetal. Our features palladium‐catalyzed cascade cyclization reaction to set tricyclic carbon framework desired molecules, regioselective Baeyer–Villiger oxidation followed by MeNH 2 triggered skeletal reorganization construct benzannulated aza [4.4.3]propellane, strategically late‐stage...
Herein, we present the first racemic total synthesis of structurally complex monoterpene indole alkaloids rhynchines A–E, starting from commercially available methyl nicotinate and 3-(2-bromoethyl)-1H-indole. The success our is attributed to utilization a bioinspired synthetic strategy, which facilitated rapid construction pentacyclic core skeleton target molecules through biomimetic skeletal rearrangement late-stage C–H oxidative cyclization. Additionally, silica-gel-promoted...
Glucagon-like peptide-1 (GLP-1) is a short peptide that can significantly reduce blood glucose level. Recombination oral long-acting glucagon-like (rolGLP-1), GLP-1 analog generated from site-specific mutation of GLP-1. CTB non-toxic portion the cholera toxin and an ideal protein antigen carrier. In this study, we firstly constructed vector pET-22b (+)-CTB-10×rolGLP-1 to express fusion composed ten tandem repeated rolGLP-1 in BL21 (DE3) line E.coli. The CTB-10×rolGLP-1 was expressed...
In Gegenwart eines Evans-Oxazolidinons als chiralem Auxiliar addiert das Anion von α-Diazoacetamid hoch stereoselektiv an aromatische N-Tosylimine (siehe Schema). Die Additionsprodukte können in einer kurzen Synthese gezielt syn- und anti-α-Hydroxy-β-aminosäurederivate umgewandelt werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z460730_s.pdf or from author. Please note: The publisher not responsible content...
Recombinant orally long-acting glucagon-like peptide 1 (rolGLP-1), a novel analog of native GLP-1 that can stimulate insulin secretion, was constructed via site-directed mutagenesis by our laboratory. This study designed to investigate the pharmacokinetics, pharmacodynamics, and cytotoxicity rolGLP-1. Diabetic <i>db/db</i> mice were given <sup>125</sup>I-rolGLP-1 through single dose oral administration evaluate pharmacokinetics rolGLP-1 trichloroacetic acid-Radioactive assay (TCA-RA)....
(N-Tosyl)amino substituted β-keto diazo carbonyl compounds have been prepared by reaction of titanium enolate β-ketodiazoester or -ketone with an activated N-tosylimine. Rh2(OAc)4-catalyzed the (N-tosyl)amino α-diazocarbonyl leads to efficient formation pyrrole derivatives.
Abstract Aromatic α-hydroxyiminoacetonitriles can be conveniently prepared by a facile one-pot procedure in high yields involving chlorination of the corresponding aldoximes with tert-butyl hypochlorite followed reaction alkali cyanide.