A5011580097- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Peroxisome Proliferator-Activated Receptors
- Dental Implant Techniques and Outcomes
- Adipose Tissue and Metabolism
- Dental materials and restorations
- Microbial Metabolic Engineering and Bioproduction
- Pelvic and Acetabular Injuries
- Cerebral Palsy and Movement Disorders
- Dermatologic Treatments and Research
- Management of metastatic bone disease
- Dental Research and COVID-19
- Cardiac Ischemia and Reperfusion
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Musculoskeletal pain and rehabilitation
- Hip and Femur Fractures
- Cardiovascular Function and Risk Factors
- Neurological and metabolic disorders
- Diagnosis and Treatment of Venous Diseases
- Abdominal vascular conditions and treatments
- Venous Thromboembolism Diagnosis and Management
Ain Shams University
2011-2024
Ministry of Health
2023
Ain Shams University Hospital
2023
Tanta University Hospital
2023
Military Hospital
2023
Royal Oldham Hospital
2023
Cairo University
2023
Royal Hospital
2023
Benha University
2021
Ministry Of Health
2020
Very-long-chain acyl-CoA dehydrogenase (VLCAD) is one of four straight-chain (ACD) enzymes, which are all nuclear encoded mitochondrial flavoproteins catalyzing the initial step in fatty acid beta-oxidation. We have used very fast, Rapid Amplification cDNA Ends (RACE) based strategy to obtain sequence cDNAs encoding human VLCAD from placenta and fibroblasts. Alignment predicted amino with those other ACD enzymes revealed extensive homology. Moreover, oxidase showed homology corroborating...
The accumulation of β-oxidation intermediates was studied by incubating normal and enzyme-deficient human fibroblasts with [2H4]linoleate L-carnitine analyzing the resultant acylcarnitines tandem mass spectrometry. Labeled decenoyl-, octanoyl-, hexanoyl-, butyrylcarnitines were only observed cells. Intermediates longer chain length, corresponding to substrates for enzymes associated inner mitochondrial membrane, not unless a cell line deficient in one these enzymes, such as very-long-chain...
The mitochondrial metabolism of 5-enoyl-CoAs, which are formed during the beta-oxidation unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms, was studied extracts and purified enzymes beta-oxidation. Metabolites were identified spectrophotometrically by high performance liquid chromatography. 5-cis-Octenoyl-CoA, a putative metabolite linolenic acid, efficiently dehydrogenated medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3) to 2-trans-5-cis-octadienoyl-CoA,...
Several inherited disorders of fatty acid beta-oxidation have been described that relate mainly to saturated precursors. This study is the first report an enzyme defect related only unsaturated oxidation and provides in vivo evidence fat humans proceeds by reductase-dependent pathway. The patient was a black female, presenting neonatal period with persistent hypotonia. Biochemical studies revealed hyperlysinemia, hypocarnitinemia, normal organic profile, unusual acylcarnitine species both...
BACKGROUND: Children with cerebral palsy (CP) can present severe secondary dystonia or without associated spasticity of their extremities. OBJECTIVE: To assess the outcomes combined anterior and posterior lumbar rhizotomy for treatment mixed hypertonia in lower extremities children CP. METHODS: Fifty CP were subjected to rhizotomies a prospective study. Clinical outcome measurements recorded preoperatively evaluated at 2, 6, 12 months postoperatively. The operative techniques performed by...
Amniocytes isolated from two pregnancies at risk for fatty acid oxidation defects were incubated with stable isotopically labelled palmitate, in the presence of L-carnitine, to probe that pathway. The acylcarnitines then quantitated using tandem mass spectrometry. a pregnancy medium-chain acyl-CoA dehydrogenase (MCAD) deficiency produced characteristic acylcarnitine profile increased levels octanoylcarnitine and decanoylcarnitine, indicative MCAD deficiency. DNA analysis confirmed fetus was...
Background The treatment of varicose veins has undergone tremendous changes over the years. High ligation saphenofemoral junction (SFJ) and stripping great saphenous vein (GSV) have been considered standard treatments for GSV insufficiency a century are still adopted as preferred method in majority surgical centers North Africa. However, increase minimally invasive such endovenous thermal ablation (EVTA), radiofrequency (RFA), ultrasound-guided foam sclerotherapy, cryo-stripping produced...
Introduction: Hypocalcemia is an important and common complication following thyroid surgery with reports varying from 0.5% to 75%. Despite being self-limiting in most patients, symptomatic hypocalcemia of particular concern because a delay its manifestation the consequent need for prolonged patient hospitalization or re-admission. Aim Work: The aim this study evaluate clinical usefulness oral calcium vitamin D administration after total thyroidectomy prevention post-operative hypocalcemia....
Abstract Objective The aim of our study was to assess cases trigeminal pain by MRI evaluate the underlying pathology and correlate imaging findings with clinical data. Materials methods Forty-five patients (28 males 17 females) or without other associated neurologic symptoms signs were included in this study. brain, dedicated view protocol conducted contrast injection selected according conventional scan. Detailed assessment course nerve (anatomical based assessment). Results MR could depict...
Thoracic and lumbar fractures represent nearly 90% of traumatic spine injuries. Thoracolumbar region is susceptible to injury because its location between the stiff kyphotic thoracic mobile lordotic region. To compare short-segment fixation with screws into index level long-segment in maintaining angle correction pain. A prospective study included 91 patients, who had single-level thoracolumbar fracture Cobb's ≤ 25° underwent posterior fixation. Forty-four patients level, 47 skipped level....
Aim: The present study aimed at developing nurses` performance guidelines for patients undergoing cholecystectomy based on needs assessment. Methods: A descriptive exploratory design was utilized the conduction of this study. This conducted in surgical departments El demerdash Hospital, affiliated to Ain Shams University. Sample: convenient sample 50 nurses from both genders wards working with (open and laparoscopic) cholecystectomy. They were recruited above-mentioned settings. Tools: 1)...
Food safety is an emerging global issue that impacts world trade and human health. Bacillus cereus among the most significant foods borne pathogens. 50 total random samples of karish cheese were obtained from a variety food markets in Governorate El-Menoufia. They investigated bacteriologically order to isolate, B. species. According bacteriological analysis, 70% tested contained The isolates resistance Amoxicillin, Penicillin, Amoxicillin Clavulanic acid. Contrarily, they susceptible...
Ingestion of magnetic foreign bodies in children can present elusively on radiographs, requiring detailed history for accurate intervention guidance. Clustering and the weight multiple magnets may indicate falsely distal positions GI tract.
Introduction: One of the most common symptoms that patients have in any hospital surgery departments is hemorrhoids.There are several ways treating them.Many different types energy devices recently been used for hemorrhoidectomy to improve intraoperative hemostasis and lessen postoperative pain. Ain work: Evaluation role harmonic scalpel versus an open closed hemorrhoidectomy.Patients methods: Twenty with hemorrhoids underwent without use a group 1, twenty 2, using 3. Sixty both genders had...
Background: In the context of acute mesenteric ischemia (AMI), extent bowel resection poses a surgical complexity due to potential exacerbation postsurgery. Consequently, employing damage-control surgery (DCS) alongside subsequent second-look operation presents an opportunity effectively address critical state patient and evaluate viability after resuscitative measures.Objectives: Evaluate role DCS in salvaging small segments that were doubtful during primary necrotic bowel. Assess overall...