A5112620903- Plant Gene Expression Analysis
- Horticultural and Viticultural Research
- Berry genetics and cultivation research
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cell death mechanisms and regulation
- Genomics and Phylogenetic Studies
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Hepatitis B Virus Studies
- Plant biochemistry and biosynthesis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Plant Pathogens and Fungal Diseases
- Cancer and Skin Lesions
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Ginseng Biological Effects and Applications
- Neurofibromatosis and Schwannoma Cases
- Plant and Fungal Species Descriptions
- Esophageal and GI Pathology
Shandong Provincial Hospital
2005-2025
Shandong First Medical University
2021-2025
Fujian Medical University
2025
Xiamen University
2025
Ningxia Academy of Agriculture and Forestry Sciences
2019-2023
Shandong Provincial QianFoShan Hospital
2013-2021
Zhongda Hospital Southeast University
2021
Shandong University
2013-2020
Shandong Center for Disease Control and Prevention
2017
Hangzhou First People's Hospital
2011-2016
Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these portal hypertension (PH) patients has been poorly evaluated.To evaluate diagnosis PH.A total 238 underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze variables associated with PH grade. Then, performances seven indexes, aspartate aminotransferase...
Abnormally expressed long noncoding RNAs (lncRNAs) have been reported to affect the occurrence and progression of hepatocellular carcinoma (HCC) by modulating autophagy axis. However, none studies has explored clinical significance these autophagy-related lncRNAs in HCC comprehensively. In this study, RNA-seq, miRNA-seq, data normal patients from TCGA database genes Human Autophagy Database were extracted. Subsequently, we screened out 78 differentially lncRNAs, four prognostic-related...
Aims: TIPE2 is a novel inflammation regulator, and the role of in colitis-induced colon cancer not clear. The aim this study was to test whether inhibits TLR4 pathway patients explore potential mechanism TI
Lycium barbarum and L. ruthenicum have been used as traditional medicinal plants in China other Asian counties for centuries. However, the molecular mechanisms underlying fruit development ripening, well associated production of nutritional components, little explored these two species.A competitive transcriptome analysis was performed to identify regulators pathways involved ripening red wolfberry (L. barbarum) black ruthenicum) using an Illumina sequencing platform. In total, 155,606 genes...
Amiodarone is a class III antiarrhythmic drug that commonly used in the clinic to treat ventricular arrhythmias and atrial fibrillation. We present case report of adverse effects amiodarone review its characteristics.
Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is risk early rebleeding after endoscopic treatment (EVT). Thrombocytopenia the most common hemostatic abnormality in cirrhosis. However, it still unclear about whether thrombocytopenia increases failure EVT cirrhotic patients with AVB. Objectives: We investigated association between and Design: International multicenter, retrospective study....
Abstract The immunosuppressive tumor microenvironment (TME) is a critical determinant of therapeutic resistance in colorectal cancer (CRC). TME encompasses diverse cellular and stromal elements, including cells, immune extracellular matrix (ECM), lymphatic vessels. Among these components, tumor-associated macrophages (TAMs) predominate both quantitatively functionally, with M2-polarized being the principal subset responsible for immunosuppression. Identifying genes that promote M2...
At present, there is no perfect noninvasive method to assess portal hypertension and esophageal varices. Early predicting varices can provide evidence for managing cirrhotic patients. We aimed further investigate von Willebrand factor (vWF) as a predictor of hypertension, especially varices.A total 60 hepatitis B patients with cirrhosis 45 healthy subjects were enrolled in this study. Levels six markers examined. All underwent hepatic venous pressure gradient (HVPG)...
AIM:To determine the role of Fas/Fas ligand (FasL) in immune escape colon cancer cells. METHODS:Immunohistochemistry was used to observe expression Fas and FasL tissues patients.In situ hybridization detect localization mRNA tissues.Terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay CD45 staining were performed apoptosis tumor-infiltrating lymphocytes (TILs).Co-culture assays cells (SW480) Jurkat (Fas-sensitive cells) counterattack lymphocytes. RESULTS:Of 53...
Previous studies found that glucocorticoids were closely associated with the oncogenesis and development of numerous types tumors. The aim present study was to investigate effect dexamethasone on growth angiogenesis Lewis lung cancer cells in mice who received palliative surgery. carcinoma inoculated subcutaneously into right axilla C57BL/6 mice. When tumor diameter reached 0.5 cm, 2 weeks later, surgery performed, randomly divided 3 groups 6 animals each group (control group, cisplatin...
Objectives Peptic ulcer is the most common source of non-variceal bleeding. However, it remains controversial whether outcomes cirrhotic patients with peptic bleeding differ from those variceal
To observe the influence of popular antitumor drugs [5-fluorouracil (5-FU), mitomycin (MMC), cisplatin (CP) and all-trans retinoic acid (ATRA)] on expression Fas system in SW480 colon cancer cells.The expressions Fas/FasL protein mRNA line cells before after treatment (5-FU, MMC, CP ATRA) were detected by immunocytochemistry, flow cytometry reverse-transcriptase polymerase chain reaction. Coculture assays Jurkat (Fas-sensitive cells) performed to counterattack lymphocytes. Apoptosis...
Esophageal squamous cell carcinoma (ESCC) accounts for almost 90% of esophageal cancer cases and is the sixth most common cause cancer-associated mortality worldwide. Cisplatin standard therapeutic reagent ESCC; however, chemoresistance frequently occurs after a few weeks, which leads to ESCC recurrence. Aberrant expression B lymphoma Mo-MLV insertion region 1 homolog (BMI1) has been reported activate multiple growth-regulatory pathways, induce antiapoptotic abilities in numerous types cells...
The Polycomb group genes are a general class of regulators that responsible for maintaining homeotic gene expression throughout cell division. plays an important role in oncogenesis several types human cancer. Melanoma nuclear protein 18 and B-cell-specific Moloney leukemia virus insert site 1 key proteins. Studies have shown melanoma is potential tumor suppression, overexpressed malignancies. However, the roles esophageal squamous carcinoma still unclear. In this study, we analyzed levels...
RLIP76 is an anti-apoptotic transporter, participating in the multi-specific drug transport and resistance. In absence of chemotherapy drugs, knockout or inhibition leads to pronounced tumor regression. transports anthracycline vinca alkaloid drugs mediates resistance these drugs. However, functions colorectal cancer remain unclear. HCT-8 vincristine (VCR)-resistant cell line HCT-8/VCR (HCT-8/V) were used present study. The effects knockdown by lentivirus examined cultured cells, including...
Rubus eucalyptus Focke belong to genus in the family Rosaceae, fresh fruits of which can be used for medicine and cosmetic. The plastome R. is 155,672 bp length, with one large single copy region 85,277 bp, small 18,864 two inverted repeat (IR) regions 25,748 bp. It contains 130 genes, including 86 protein-coding 8 ribosomal RNA, 37 transfer RNA. Phylogenetic tree shows that was at basal Rosaceae. published within provides significant insight elucidating phylogenetic relationship taxa tribe
Glycyrrhiza uralensis is a tradational Chinese medicine of Leguminosae, which contains many chemicals, such as glycyrrhizin, liquiritin glycyrol, melatonin (N-acetyl-5-methoxy tryptamine), glycyrrhizol A, B and four known isoflavonoids (5-O-methylglycryol, isoglycyrol, 6,8-diisoprenyl-5,7,4′-trihydroxy isoflavone, gancaonin).Illumina paired-end reads data was used to assemble the complete chloroplast (cp) genome. About 15,445,866 raw Paired-End Reads length distribution in 127,702 bp (GC...
Ectopic breast tissue is reported to occur in 0.4% - 6% of women. Breast neoplasms may develop ectopic tissue, as eutopic tissue. The most frequent condition cancer. Fibroadenomas have been reported, but are rare. We report two cases fibroadenomas axillary tissues. sonographic appearance the nodules was spherical and hypoechoic. found component near nodule. It important diagnose before a histologic examination.
This study introduces a meticulously constructed genome assembly at the chromosome level for Rosaceae family species Prinsepia uniflora, traditional Chinese medicinal herb. The final encompasses 1272.71 megabases (Mb) distributed across 16 pseudochromosomes, boasting contig and super-scaffold N50 values of 2.77 79.32 Mb, respectively. Annotated within this is substantial 875.99 Mb repetitive sequences, with transposable elements occupying 777.28 constituting 61.07% entire genome. Our...