A5009210353- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Diet and metabolism studies
- Diversity and Career in Medicine
- Tryptophan and brain disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- ATP Synthase and ATPases Research
- Alzheimer's disease research and treatments
- Metabolism, Diabetes, and Cancer
- Redox biology and oxidative stress
- Prostate Cancer Diagnosis and Treatment
University of Rochester
2024
University of Rochester Medical Center
2022-2024
Abstract Hydrogen peroxide (H 2 O ) functions as a second messenger to signal metabolic distress through highly compartmentalized production in mitochondria. The dynamics of reactive oxygen species (ROS) generation and diffusion between mitochondrial compartments into the cytosol govern oxidative stress responses pathology, though these processes remain poorly understood. Here, we couple H biosensor, HyPer7, with optogenetic stimulation ROS-generating protein KillerRed targeted multiple...
Organisms surveil and respond to their environment using behaviors entrained by metabolic cues that reflect food availability. Mitochondria act as hubs at the center of mitochondrial energy production is protonmotive force (PMF), an electrochemical gradient generated metabolite consumption. The PMF serves a central integrator status, but its role in governing signaling poorly understood. We used optogenetics dissipate Caenorhabditis elegans tissues test food-related behaviors. Our data...
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative characterized by neuronal dysfunction leading to decreased memory and cognitive function. AD research has largely focused on the potential pathogenic role of two hallmarks: amyloid beta phosphorylated tau. However, pharmacological interventions targeting these hallmarks have met with limited clinical trial success. Thus, other variables may initiate etiology prior or contribute development tau pathologies. Iron...