A5061551299- Glycosylation and Glycoproteins Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Carbohydrate Chemistry and Synthesis
- Immune Cell Function and Interaction
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- MicroRNA in disease regulation
- Heat shock proteins research
- Autophagy in Disease and Therapy
- Hedgehog Signaling Pathway Studies
- Clusterin in disease pathology
- Advanced Proteomics Techniques and Applications
- Cancer Mechanisms and Therapy
- Inflammasome and immune disorders
- Proteoglycans and glycosaminoglycans research
- Cellular Mechanics and Interactions
- Prostate Cancer Treatment and Research
- Cancer Diagnosis and Treatment
- Immune cells in cancer
Dalian Medical University
2020-2025
First Affiliated Hospital of Dalian Medical University
2024-2025
Older patients with cancer, particularly those over 75 years of age, often experience poorer clinical outcomes compared to younger patients. This can be attributed age-related comorbidities, weakened immune function, and reduced tolerance treatment-related adverse effects. In the checkpoint inhibitors (ICI) era, age has emerged as an influential factor impacting discovery predictive biomarkers for ICI treatment. These age-linked changes in system influence composition functionality...
Clear cell renal carcinoma (ccRCC) is a globally severe cancer with an unfavorable prognosis. PANoptosis, form of death regulated by PANoptosomes, plays role in numerous types. However, the specific roles genes associated PANoptosis development and advancement ccRCC remain unclear. Our study developed risk model utilizing three PANoptosis-associated (Caspase 4 (CASP4), TLR3, CASP5). This demonstrated high degree precision predicting prognosis for patients ccRCC. high-risk group had strongest...
Kidney renal clear cell carcinoma (KIRC), a therapy-resistant aggressive kidney cancer, exhibits resistance to immune checkpoint inhibitors. Altered sialylation is involved in tumor development, affecting microenvironment dynamics. In the study, through systematic bioinformatics analysis and experimental verification, we demonstrated that ST3Gal5 expression was elevated tissues of KIRC patients, correlating with poor prognosis, ST3Gal1 downregulated associated better prognosis....
Abstract Background CD56 has been observed in malignant tumours exhibiting neuronal or neuroendocrine differentiation, such as breast cancer, small-cell lung and neuroblastoma. Abnormal glycosylation modifications are thought to play a role regulating tumour cell proliferation, migration, invasion. Nevertheless, the exact roles molecular mechanisms of polysialylated (PSA-CD56) development progression clear renal carcinoma (ccRCC) remain elusive. Here we unveil biological significance...
ST3Gal IV is one of the principal sialyltransferases responsible for biosynthesis α2, 3-sialic acid to termini N -glycans or O- glycans glycoproteins and glycolipids. It has been reported that expression associated with gastric carcinoma, pancreatic adenocarcinoma breast cancer. While functions in cervical cancer are still poorly understood. In this study, we found was downregulated human tissues compared normal cervix tissues, negatively pathological grade upregulation inhibited growth...
<title>Abstract</title> Bladder cancer (BC) ranks as the fourth in males and tenth most common worldwide. Conventional treatment modalities, including surgery, radiation, chemotherapy, immunotherapy, have limited efficacy certain advanced instances. The involvement of GALNT6-mediated aberrant O-glycosylation modification several malignancies immune evasion is a subject speculation. However, its significance BC has not been investigated. Through integration bioinformatics analysis laboratory...
Background. The most common site of prostate cancer metastasis is bone tissue with many recent studies having conducted genomic and clinical research regarding metastatic cancer. However, further work needed to better define those patients that are at an elevated risk such metastasis. Methods. SEER TCGA databases were searched develop a nomogram for predicting Results. Herein, we leveraged the Surveillance, Epidemiology, End Results (SEER) database construct predictive capable readily...
Background: Clear cell renal carcinoma (ccRCC), the predominant subtype of RCC, is distinguished by unique biological characteristics and heterogeneity, including eosinophilic clear subtypes. Notwithstanding progress in therapy, immune checkpoint inhibitors (ICIs), tyrosine kinase (TKIs), prognosis for individuals with metastatic ccRCC remains poor, presumably owing to metabolic alterations leading mitochondrial dysfunction, which affects treatment response variability. Methods: We analyzed...