A5027873242- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Multimodal Machine Learning Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Diet and metabolism studies
- Domain Adaptation and Few-Shot Learning
- Face recognition and analysis
Northwest A&F University
2021-2025
Shanghai Jiao Tong University
2024
Heat stress causes many pathophysiological responses in the brain, including neuroinflammation and cognitive deficits. β-Hydroxybutyric acid (BHBA) has been shown to have neuroprotective effects against inflammation induced by lipopolysaccharide. The aim of present study was evaluate BHBA on heat stress, as well underlying mechanisms. Mice were pretreated with vehicle, or minocycline (positive control group) followed exposure (43°C) for 15 min 14 days. In mice subjected we found that...
I-motifs are noncanonical four-stranded DNA structures formed by C-rich sequences at acidic environment with critical biofunctions. The particular pH sensitivity has inspired the development of i-motifs as sensors and motors in nanotechnology. However, folding regulation mechanisms remain elusive. Here, using single-molecule FRET, we first show that more dynamic than G4s. Impressively, display a high diversity six species slow interconversion. Further results indicate can be linearized...
Ribonuclease P (RNase P) plays a vital role in the maturation of tRNA across bacteria, archaea, and eukaryotes. However, how RNase assembles various components to achieve specific cleavage precursor (pre-tRNA) different organisms remains elusive. In this study, we employed single-molecule fluorescence resonance energy transfer probe dynamics from E. coli ( Escherichia ) Mja Methanocaldococcus jannaschii during pre-tRNA by incorporating five Cy3-Cy5 pairs into P. Our results revealed...