A5103011696- Hydraulic and Pneumatic Systems
- Welding Techniques and Residual Stresses
- Bone Metabolism and Diseases
- Spine and Intervertebral Disc Pathology
- Iterative Learning Control Systems
- Non-Destructive Testing Techniques
- Advanced Welding Techniques Analysis
- Advanced Electron Microscopy Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Advanced Photocatalysis Techniques
- Hydraulic Fracturing and Reservoir Analysis
- Bone health and treatments
- Simulation and Modeling Applications
- Bone health and osteoporosis research
- Reservoir Engineering and Simulation Methods
- Cancer-related molecular mechanisms research
- Control Systems in Engineering
- Oil and Gas Production Techniques
- Circular RNAs in diseases
- Hydrogen embrittlement and corrosion behaviors in metals
- Copper-based nanomaterials and applications
- Hydrocarbon exploration and reservoir analysis
- Structural Health Monitoring Techniques
- Catalytic Processes in Materials Science
- TGF-β signaling in diseases
Institute of Computing Technology
2019-2025
Chinese Academy of Sciences
2021-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2013-2024
Guangzhou University of Chinese Medicine
2018-2024
University of Chinese Academy of Sciences
2021-2024
Huawei Technologies (China)
2024
Jiangsu University of Science and Technology
2016-2024
Beijing Institute of Technology
2023-2024
Lanzhou University
2024
Shanxi University
2020-2023
BackgroundForkhead box protein f1 (Foxf1) is associated with cell differentiation, and may be a key player in bone homoeostasis. However, the effect of Foxf1 on osteogenesis marrow-derived mesenchymal stem cells (BMSCs) ovariectomy-induced loss, as well its clinical implications, unknown.MethodsBy quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) western blotting, we assayed expression tissue, BMSCs, macrophages (BMMs), derived from ovariectomised (OVX) mice, during...
Previous studies indicated that let-7 enhances osteogenesis and bone formation of human adipose-derived mesenchymal stem cells (MSCs).We also have confirmed let-7f-5p expression was upregulated during osteoblast differentiation in rat marrow-derived MSCs (BMSCs) downregulated the vertebrae patients with glucocorticoid (GC)-induced osteoporosis (GIOP).The study performed to determine role GC-inhibited osteogenic murine BMSCs vitro GIOP vivo.Here, we report dexamethasone (Dex) inhibited...
Plastrum testudinis extracts (PTE) show osteoprotective effects on glucocorticoid-induced osteoporosis in vivo and vitro. However, the underlying molecular mechanism of PTE promoting osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) is unclear.BMSC proliferation was investigated using Cell Counting Kit-8 assay. BMSC mineralization were assayed alkaline phosphatase Alizarin red staining, respectively. The mRNA expression levels Let-7f-5p, Tnfr2, Traf2, Pi3k, Akt,...
Postmenopausal osteoporosis (PMOP) is a severe health issue faced by postmenopausal women.microRNA-128 (miR-128) associated with aging, inflammatory signaling, and diseases, such as PMOP.It has also been reported to modulate in vitro osteogenic/adipogenic differentiation.However, its function osteoclast formation unknown.Methods: First, the expression of miR-128 nuclear factor activated T cells 1 (Nfatc1, bone resorption master marker) was investigated tissues derived from PMOP patients,...
Cryo-electron microscopy (cryo-EM) is a widely used technology for ultrastructure determination, which constructs the 3D structures of protein and macromolecular complex from set 2D micrographs. However, limited by electron beam dose, micrographs in cryo-EM generally suffer extremely low signal-to-noise ratio (SNR), hampers efficiency effectiveness downstream analysis. Especially, noise not simple additive or multiplicative whose statistical characteristics are quite different ones natural...
Accumulating evidence indicates that circular RNAs (circRNAs) play vital roles in tumorigenesis by modulating gene expression. However, the molecular mechanisms underlying functions of circRNAs remain largely unknown. Here, we demonstrated a Yes1 associated transcriptional regulator (YAP1)-derived circRNA, circ-LECRC (circRNA low expressed CRC), was significantly downregulated colorectal cancer (CRC). High expression positively correlated with lower TNM stage and good prognosis CRC patients....
Solar-driven CO2 reduction into fuels and chemicals has gained increasing attention in recent years. In this study, oxygen-vacancies-functionalized Ni(OH)2 (OVs-Ni(OH)2 ) nanosheets are synthesized by a photochemical method to serve as catalyst for reduction. Characterization reveals that COOH* is the key intermediate -to-CO photoreduction. Experimental results theoretical calculations confirm OVs modification can greatly modulate interaction strength between OVs-Ni(OH)2 , while lowering...
Objective To evaluate the influence of insufficient bone cement distribution on outcomes following percutaneous vertebroplasty (PVP). Methods This retrospective matched-cohort study included patients 50–90 years age who had undergone PVP for single level vertebral compression fractures (VCFs) from February 2015 to December 2018. Insufficient (Group A)/sufficient B) in fracture area was assessed pre- and post-operative computed tomography (CT) images. Assessments were before, 3-days...