A5021365947- Advanced Polymer Synthesis and Characterization
- Organometallic Complex Synthesis and Catalysis
- Astro and Planetary Science
- Polymer Surface Interaction Studies
- Radical Photochemical Reactions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Photopolymerization techniques and applications
- Planetary Science and Exploration
- Oxidative Organic Chemistry Reactions
- Conducting polymers and applications
- Magnetism in coordination complexes
- Synthesis and properties of polymers
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- biodegradable polymer synthesis and properties
- Ionosphere and magnetosphere dynamics
- Molecular Junctions and Nanostructures
- Fluorine in Organic Chemistry
- Crystallization and Solubility Studies
- Dendrimers and Hyperbranched Polymers
- Antimicrobial agents and applications
- Machine Learning in Materials Science
- Solar and Space Plasma Dynamics
University of Warwick
2016-2025
Ingenierie des Materiaux polymeres
2025
Southwest Research Institute
2013-2024
University of Nottingham
1995-2024
Coventry (United Kingdom)
2013-2021
Monash University
2014-2019
Division of Chemistry
2015-2017
Australian Regenerative Medicine Institute
2014-2015
University of Leicester
2014
University of Bath
2002-2012
Photoinduced living radical polymerization of acrylates, in the absence conventional photoinitiators or dye sensitizers, has been realized "daylight'"and is enhanced upon irradiation with UV radiation (λmax ≈ 360 nm). In presence low concentrations copper(II) bromide and an aliphatic tertiary amine ligand (Me6-Tren; Tren = tris(2-aminoethyl)amine), near-quantitative monomer conversion (>95%) obtained within 80 min, yielding poly(acrylates) dispersities as 1.05 excellent end group fidelity...
A new approach to perform single-electron transfer living radical polymerization (SET-LRP) in water is described. The key step this process allow full disproportionation of CuBr/Me6TREN (TREN = tris(dimethylamino)ethyl amine Cu(0) powder and CuBr2 prior addition both monomer initiator. This provides an extremely powerful tool for the synthesis functional water-soluble polymers with controlled chain length narrow molecular weight distributions (polydispersity index approximately 1.10),...
The Jovian Auroral Distributions Experiment (JADE) on Juno provides the critical in situ measurements of electrons and ions needed to understand plasma energy particles processes that fill magnetosphere ultimately produce its strong aurora. JADE is an instrument suite includes three essentially identical electron sensors (JADE-Es), a single ion sensor (JADE-I), highly capable Electronics Box (EBox) resides Radiation Vault all necessary control, low high voltages, computing support for four...
The Integrated Science Investigation of the Sun (ISIS) is a complete science investigation on Solar Probe Plus (SPP) mission, which flies to within nine solar radii Sun’s surface. ISIS comprises two-instrument suite measure energetic particles over very broad energy range, as well coordinated management, operations, data processing, and scientific analysis. Together, observations allow us explore mechanisms dynamics, including their: (1) Origins—defining seed populations physical conditions...
This paper describes the science motivation, measurement objectives, performance requirements, detailed design, approach and implementation, calibration of four Hot Plasma Composition Analyzers (HPCA) for Magnetospheric Multiscale mission. The HPCA is based entirely on electrostatic optics combining an energy analyzer with a carbon-foil time-of-flight analyzer. In order to fulfill mission incorporates three unique technologies that give it very wide dynamic range capabilities essential...
Abstract The MAss Spectrometer for Planetary EXploration (MASPEX) is a high-mass-resolution, high-sensitivity, multi-bounce time-of-flight mass spectrometer (MBTOF) capable of measuring minor species with abundances sub-parts-per-million in Europa’s sputter-produced and radiolytically modified exosphere its oceanic plumes. goal the MASPEX-Europa investigation to determine, through in-situ measurement plume composition, whether conditions habitability exist or have existed on Europa. As...
A versatile and inexpensive photochemical platform for the preparation of high-order multiblock functional materials.
Aqueous single electron transfer living radical polymerization (SET-LRP) has been employed to synthesize multi-block homopolymers and copolymers of a range acrylamide monomers including <italic>N</italic>-isopropylacrylamide (NIPAM), 2-hydroxyethyl (HEAA), <italic>N</italic>,<italic>N</italic>-dimethyl (DMA) <italic>N</italic>,<italic>N</italic>-diethylacrylamide (DEA).
The synthesis of well-defined high molecular weight block copolymers by sequential in situ chain extensions via Cu(0)-mediated living radical polymerization is reported. Optimal conditions for iterative formation were determined using model homopolymer quasiblock systems, including methyl acrylate (MA), ethyl (EA), and n-butyl (nBA; each DPn ≈ 100). PDI after extension was below 1.2, with good agreement between theoretical experimental weights, while the conversion monomer incorporation into...
Dithiomaleimides (DTMs) with alkyl substituents are shown to be a novel class of highly emissive fluorophores. Variable solubility and further functionalization can easily tailored through the choice N S substituents. Inclusion DTM unit into ROP/RAFT initiator or insertion disulfide bond salmon calcitonin (sCT) demonstrates utility for fluorescent labeling polymers proteins. Simultaneous PEGylation sCT is also demonstrated, using as both linker fluorophore. It anticipated that DTMs will...
Multivalent glycopolymers exhibit a strong affinity for specific lectin proteins depending on their carbohydrate functionality. In this work, we report facile one-pot synthesis of diblock PEG-glycopolymers using combination Cu(0) mediated living radical polymerization and click chemistry to attach three different carbohydrates, α-D-mannose, α-D-glucose β-D-glucose, iron oxide nanoparticle (IONP) surfaces. The resultant IONP@P(OEGA)-b-P(sugar) nanoparticles were then extensively characterized...
The combination of copper(0) mediated living radical polymerization (Cu(0)-LRP) with thiol–halogen, thiol–epoxy and copper catalysed alkyne azide coupling (CuAAC) click chemistry has been employed to give a new route multiblock sequence-controlled glycopolymers.
Photoinduced living radical polymerization of acrylates is achieved upon UV irradiation (λmax ≈ 360 nm) in the presence an aliphatic tertiary amine ligand (Me6-Tren) low concentrations CuBr2, yielding poly(acrylates) with near perfect retention end group fidelity. The effect nature solvent on rate was investigated order to expand scope and identify limitations system. Subsequently, a range acrylic monomers containing hydrophobic hydrophilic substituents have been screened, including lauryl...
Photoinduced living radical polymerization has been employed to synthesize α,ω-telechelic multiblock copolymers of a range acrylic monomers including methyl acrylate (MA), ethyl (EA), ethylene glycol ether (EGA), and solketal (SA). Under carefully optimized conditions, well-defined tricosablock (23 blocks) copolymer was obtained (Đ = 1.18) with high conversion (>98%) achieved throughout all the iterative monomer additions. Crucially, reduced temperature (15 °C) found result in an observed...
Abstract Measurement of molecular weight is an integral part macromolecular and polymer characterization which usually has limitations. Herein, this article presents the use a bench‐top 80 MHz Nuclear Magnetic Resonance (NMR) spectrometer for diffusion‐ordered spectroscopy as practical rapid approach determination weight/size using novel solvent polymer‐independent universal calibration.
The synthesis of well-defined protein/peptide-polymer conjugates with interesting self-assembly behavior via single electron transfer living radical polymerization in water is described. A range protein/peptides different physical and chemical properties have been modified to macroinitiators optimized conditions ensure successful from soluble, insoluble, dispersed protein/peptide molecules or protein aggregates. This powerful strategy tolerates a functional monomers mediates efficient homo...
The controlled polymerization of <italic>N</italic>-isopropyl acrylamide (NIPAM) is reported in a range international beers, wine, ciders and spirits utilizing Cu(0)-mediated living radical (SET-LRP).
Herein, we demonstrate the synthesis of well-defined poly(n-alkyl acrylate)s via copper(0)-mediated radical polymerisation in a self-generating biphasic system. During n-butyl acrylate DMSO, polymer phase separates to yield polymer-rich layer with very low copper content (ICP-MS analysis: 0.016 wt%). The poly(n-butyl acrylate) has been characterized by range techniques, including GPC, NMR and MALDI-TOF, confirm both controlled character end group fidelity. Moreover, have successfully chain...
The entropy-driven affinity of trivalent (in)organic arsenicals for closely spaced dithiols has been exploited to develop a novel route peptide/protein–polymer conjugation. A arsenous acid (As(III)) derivative (1) obtained from p-arsanilic (As(V)) was shown readily undergo conjugation the therapeutic peptide salmon calcitonin (sCT) via bridging Cys1-Cys7 disulfide, which verified by RP-HPLC and MALDI-ToF-MS. Conjugation proceed rapidly (t < 2 min) in situ stoichiometrically through...
A photo-polymerization protocol, utilizing a pre-formed and well-characterized Cu(<sc>ii</sc>) formate complex, [Cu(Me<sub>6</sub>-Tren)(O<sub>2</sub>CH)](ClO<sub>4</sub>), mediated by UV light is described.
Atom transfer radical polymerization (ATRP) of acrylamide (AM) has proved challenging, typically exhibiting low conversions and broad molecular weight distributions (MWDs). Herein, we report the synthesis well-defined polyacrylamide (both homo block copolymers) via aqueous copper(0)-mediated reversible-deactivation (Cu(0)-RDRP), exploiting in situ disproportionation Cu(I)Br presence Me6Tren to yield insoluble Cu(0) Cu(II)Br2 which acts as a deactivator. Careful optimization levels Me6TREN...
There is an urgent unmet medical need for new treatments wound and burn infections caused by multidrug-resistant Gram-negative "superbugs," especially the problematic Pseudomonas aeruginosa. In this work, incorporation of colistin, a potent lipopeptide into self-healable hydrogel (via dynamic imine bond formation) following chemical reaction between amine groups present in glycol chitosan aldehyde-modified poly(ethylene glycol), reported. The storage module (G') colistin-loaded ranges from...
Well-defined fluorescent functional polymers with terminal catechol groups were synthesized by SET-LRP under aqueous conditions for “<italic>grafting to</italic>” modification of iron oxide nanoparticles.