A5016460153- HIV Research and Treatment
- Ultrasound and Hyperthermia Applications
- Effects of Radiation Exposure
- NF-κB Signaling Pathways
- Head and Neck Cancer Studies
- Burn Injury Management and Outcomes
- Mosquito-borne diseases and control
- RNA regulation and disease
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- RNA modifications and cancer
- RNA Research and Splicing
- Pomegranate: compositions and health benefits
University of Birmingham
2018-2020
Aarhus University
2013
Centre National de la Recherche Scientifique
2013
Institut de Génétique Moléculaire de Montpellier
2013
Aarhus University Hospital
2010-2012
The HIV-1 Rev protein mediates export of unspliced and singly spliced viral transcripts by binding to the response element (RRE) recruiting cellular factor CRM1. Here, we investigated recruitment transcription sites reporters that splice either post- or cotranscriptionally. In both cases, observed localized recruited CRM1 remained at reporter when cells were treated with splicing inhibitor Spliceostatin A (SSA), showing proteins associate RNA prior during early spliceosome assembly....
Abstract Viral replication is defined by the cellular microenvironment and one key factor local oxygen tension, where hypoxia inducible factors (HIFs) regulate response to oxygen. Human immunodeficiency virus (HIV) infected cells within secondary lymphoid tissues exist in a low-oxygen or hypoxic environment vivo. However, majority of studies on HIV latency are performed under laboratory conditions HIFs inactive. We show role for HIF-2α restricting transcription via direct binding viral...
Shape-selective recognition of nucleic acid structures by supramolecular drugs offers the potential to treat disease. The Trans Activation Response (TAR) region is a high secondary structure within human immunodeficiency virus-1 (HIV-1) RNA that complexes with virus-encoded Transactivator protein (TAT) and regulates viral transcription. Herein, we explore different metallo-supramolecular triple stranded helicates (cylinders) target TAR bulge motif inhibit formation TAR-TAT HIV infection....
Background. Radiation-induced fibrosis (RIF) is a dose-limiting complication of cancer radiotherapy and causes serious problems, i.e. restricted tissue flexibility, pain, ulceration or necrosis. Recently, we have successfully treated RIF in mouse model by intraperitoneal administration chitosan/siRNA nanoparticles directed towards silencing TNF alpha local macrophage populations, but the mechanism for therapeutic effect at lesion site remains unclear. Methods. Using same murine utilized an...