A5046031758- Estrogen and related hormone effects
- Regulation of Appetite and Obesity
- Phosphodiesterase function and regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Adipose Tissue and Metabolism
- Synthesis and Catalytic Reactions
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Nutritional Studies and Diet
- HER2/EGFR in Cancer Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Biochemical Analysis and Sensing Techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Metabolism, Diabetes, and Cancer
- Genomics and Chromatin Dynamics
- Retinoids in leukemia and cellular processes
- Cancer, Hypoxia, and Metabolism
University of Calabria
2016-2025
Pharmac
2009-2023
Matrix Research (United States)
2019
University of Salerno
2016-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2016
SDN Istituto di Ricerca Diagnostica e Nucleare
2016
Baylor College of Medicine
2009-2012
Université Grenoble Alpes
2011
Université Claude Bernard Lyon 1
2009-2011
Département de Chimie Moléculaire
2011
Abstract The omega‐3 long chain polyunsaturated fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic (EPA), elicit anti‐proliferative effects in cancer cell lines animal models. Dietary DHA EPA can be converted to their ethanolamide derivatives, docosahexaenoyl ethanolamine (DHEA), eicosapentaenoyl (EPEA), respectively; however, few studies are reported on anti‐cancer activities. Here, we demonstrated that DHEA EPEA were able reduce viability MCF‐7 breast cells whereas they did not...
Abstract Obesity confers risks to cancer development and progression but the mechanisms underlying these remain unclear. In this study, we identify a role for obesity cytokine leptin, which has been implicated previously in breast development, as determinant tumor-promoting activity of cancer-associated fibroblasts (CAF) both wild-type (WT) K303R mutant estrogen receptor-α (ERα)–expressing cells. Human CAFs stimulated greater increase proliferation migration cells expressing K303R-ERα...
The two isoforms of estrogen receptor (ER) alpha and beta play opposite roles in regulating proliferation differentiation breast cancers, with ER-alpha mediating mitogenic effects ER-beta acting as a tumor suppressor. Emerging data have reported that androgen (AR) activation inhibits ER-positive cancer progression mainly by antagonizing signaling. However, to date no studies specifically evaluated potential involvement the inhibitory androgens.ER-beta expression was examined human cell lines...
Abstract Leptin, a cytokine mainly produced by adipocytes, seems to play crucial role in mammary carcinogenesis. In the present study, we explored mechanism of leptin-mediated promotion breast tumor growth using xenograft MCF-7 45-day-old female nude mice, and an vitro model represented three-dimensional cultures. Xenograft tumors, obtained only animals with estradiol (E2) pellet implants, doubled control value after 13 weeks leptin exposure. cultures, and/or E2 enhanced cell-cell adhesion....
Obesity is a risk factor for endometrial cancer in pre- and post-menopausal women. Leptin, an adipocyte-derived hormone, addition to the control weight homeostasis, implicated multiple biological actions. A recent study demonstrated that leptin promotes growth invasiveness through STAT/MAPK Akt pathways, but molecular mechanism involved such processes still needs be elucidated. In attempt understand role of regulating cells proliferation, we have treatment reduced numbers G0/G1-phase while...
Obesity condition confers risks to breast cancer development and progression, several reports indicate that the adipokine leptin, whose synthesis plasma levels increase with obesity, might play an important role in modulating cell phenotype. Functional crosstalk occurring between leptin different signaling molecules contribute carcinogenesis. In this study, we show, human lines, enhanced expression of a chaperone protein Hsp90 resulting increased HER2 levels. Silencing gene by RNA...
// Cinzia Giordano 1, * , Francesca Chemi 2, Salvatore Panza Ines Barone 2 Daniela Bonofiglio Marilena Lanzino Angela Cordella 3 Antonella Campana Adnan Hashim 4, 5 Pietro Rizza Leggio Balázs Győrffy 7, 8, 9 Bruno M. Simões 6 Robert B. Clarke Alessandro Weisz 4 Stefania Catalano ** Sebastiano Andò 1 Centro Sanitario, University of Calabria, Arcavacata di Rende, Italy Department Pharmacy, Health and Nutritional Sciences, IRCCS SDN (Istituto Ricerca Diagnostica e...
Exosomes—small membrane vesicles secreted by both normal and malignant cells upon fusion of endosomal multivesicular bodies (MVBs) with the plasma membrane—play an important role in cell-to-cell communication. During last decade, several reports have highlighted involvement these nanovesicles many aspects breast cancer development progression, but extracellular signals governing their generation not been completely unraveled. Here, we investigated obesity hormone leptin, a well-known...
Activation of peroxisome proliferator-activated receptor gamma (PPARγ) elicits anti-proliferative effects on different tumor cells, including those derived from breast cancer. PPARγ is also expressed in several cells the microenvironment, among which associated macrophages (TAMs) play a pivotal role progression and metastasis. We explored ability synthetic natural ligands to modulate TAM polarization. The included rosiglitazone (BRL-49653), two docosahexaenoic acid (DHA) conjugates,...
Results from mice lacking the androgen receptor (AR) showed that it is critical for proper development and function of testes. The aim this study was to investigate whether a functional AR present in human sperm. expression its effects on sperm were evaluated by RT-PCR, Western Blot, Immunocytochemistry, PI3Kinase DNA laddering assays. We located at head region. Dihydrotestosterone (DHT), dose-dependent manner, leads rapid phosphorylation tyrosine, serine threonine residues effect reduced...
In situ estrogen production by aromatase conversion from androgens plays an important role in breast tumor promotion. Here, we show that 17β-estradiol (E2) can rapidly enhance enzymatic activity through increase of protein phosphorylation cancer cell lines. vivo labeling experiments and site-directed mutagenesis studies demonstrated the 361-tyrosine residue is crucial up-regulation under E2 exposure. Our results a direct involvement nonreceptor tyrosine-kinase c-Src E2-stimulated because...