A5028208020- Membrane Separation Technologies
- Microfluidic and Bio-sensing Technologies
- Analytical Chemistry and Chromatography
- Aerosol Filtration and Electrostatic Precipitation
- 3D Printing in Biomedical Research
- Smart Grid Security and Resilience
- Chemical and Physical Properties in Aqueous Solutions
- Proteins in Food Systems
- Pickering emulsions and particle stabilization
- Microencapsulation and Drying Processes
- Electrohydrodynamics and Fluid Dynamics
- Crystallization and Solubility Studies
- Diverse Specialized Academic Research
- Ionic liquids properties and applications
- RNA and protein synthesis mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Membrane-based Ion Separation Techniques
- Chromatography in Natural Products
- Pancreatic function and diabetes
- Viral Infectious Diseases and Gene Expression in Insects
- Microfluidic and Capillary Electrophoresis Applications
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
Technical University of Munich
2017-2023
German National Academic Foundation
2016
Pulsatile crossflow has often been suggested as a fouling mitigation concept for microfiltration. Besides beneficial effects regarding flux in the filtration of model suspensions, little is known about on fractionation efficiency when separating proteins complex multi-component systems. Therefore, this study focusses impact low-frequency pulsatile during microfiltration skimmed milk. We found relaxation deposited casein layer low-crossflow and thus low-transmembrane pressure phases. However,...
Robust cell retention devices are key to successful culture perfusion. Currently, tangential flow filtration (TFF) and alternating (ATF) most commonly used for this purpose. TFF, however, suffers from poor fouling mitigation, which leads high resistance product retention, ATF long residence times accumulation. In work, we propose a system filtration, takes full advantage of the mitigation effects reduces We have tested novel setup in direct comparison with XCell ATF® as well TFF model feed...
Separation of cells from produced biomolecules is a challenging task in many biotechnological downstream operations due to deposit formation the retained cells, affecting permeation target product. Compression and relaxation behavior cell deposits formed during filtration are important factors operational performance. The determination these by flux or pressure stepping experiments time- labor-intensive. In this work, we propose screening method analytical centrifugation, which capable...
Abstract Der Einsatz und die Wirtschaftlichkeit der Crossflow‐Mikrofiltration werden insbesondere durch das Auftreten von Fouling beeinträchtigt. Eine unstete Überströmung, beispielsweise eine pulsierende oder alternierende Betriebsweise, können Bildung einer Deckschicht verringern damit einen starken Fluxabfall den Rückhalt Gelöststoffen verhindern. Dadurch Prozesse mit geringer Überströmgeschwindigkeit hohem Transmembrandruck deutlich verbessert werden. Das Ausmaß Verbesserung hängt dabei...