A5052107460- Advanced Drug Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Enzyme Catalysis and Immobilization
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Protein purification and stability
- Microencapsulation and Drying Processes
- Dendrimers and Hyperbranched Polymers
- biodegradable polymer synthesis and properties
- Crystallography and molecular interactions
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Production and Characterization
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Clay minerals and soil interactions
- Osteoarthritis Treatment and Mechanisms
- X-ray Diffraction in Crystallography
- Migraine and Headache Studies
- Hydrogels: synthesis, properties, applications
- Total Knee Arthroplasty Outcomes
- Synthesis and properties of polymers
- Thermal and Kinetic Analysis
- Polymer Surface Interaction Studies
- Gastrointestinal motility and disorders
Liverpool John Moores University
2013-2023
University of Liverpool
2007
Aston University
2005
University of Nottingham
2005
University of Strathclyde
1996-2000
Queen's Medical Centre
1998
We have prepared and screened a library of novel functionalized polymers for development nanoparticle drug delivery systems. The polymer backbone consisting two ester-linked, nontoxic, biological monomers, glycerol adipic acid, was using hydrolytic enzyme. specificity the chosen enzyme yields linear with one free pendant hydroxyl group per repeat unit, which can be further functionalized. This protocol gives control over molecular weight, together ability to incorporate various amounts...
A previously unreported anhydrous polymorph (Form IV) of theophylline has been crystallized and characterized. Solubility determination, crystallization, equilibration experiments indicated that Form IV is the most thermodynamically stable polymorph. The hydration behavior was investigated by three different methods: solubility, slurry experiments. value water activity at which monohydrate form becomes investigated, these results help to explain differences reported in literature. Using...
The structure of a previously unreported polymorph anhydrous theophylline (1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione), C7H8N4O2, has been determined at 100 K and shown to have monoclinic symmetry with Z′ = 2. is named form IV experimental observation indicates that this the stable material. molecular packing consists discrete hydrogen-bonded dimers similar observed in monohydrate structure. I also chains.
The catalytic behavior of cross-linked subtilisin crystals in acetonitrile exhibits pronounced hysteresis. transesterification activity the anhydrous solvent varies as much 80-fold, depending on hydration history enzyme. In a comparison drying methods, highest rates reaction were obtained with dried by washing organic solvent. Crystals over molecular sieves air or showed significantly lower activity. all cases, full could be recovered aqueous buffer. Evidence for hysteresis was using 2H-NMR...
The anhydrous forms of theophylline and the stability relationships with monohydrate, Form M, are characterized. II, kinetically stable at room temperature considered as most form during 70-year history usage, is observed to act an intermediary for conversions between other forms. IV, thermodynamically temperature, shown be enantiotropically related II undergoes a solid state transition on heating. enantiotropic relationship Forms I was investigated, it established that only in samples...
Two novel co-polymers based on omega-pentadecalactone were enzymatically synthesized by a combination of ring-opening polymerization and polycondensation. Modified literature procedures enabled the production semi-crystalline materials with suitable molecular weights melting characteristics. Microspheres produced using an emulsion solvent evaporation method over range variables including manufacturing temperature, stirring speed duration, surfactant concentration, continuous disperse phase...