A5092815642- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
University of Edinburgh
2023-2024
Abstract Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. can be phosphorylated at up to 85 different sites, there increasing interest in whether tau phosphorylation specific epitopes, by kinases, plays an important role disease progression. The AMP-activated protein kinase (AMPK)-related enzyme NUAK1 has been identified as potential mediator pathology, whereby NUAK1-mediated Ser356 prevents the degradation proteasome, further...
Abstract Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. can be phosphorylated at up to 85 different sites, there increasing interest in whether tau phosphorylation specific epitopes, by kinases, plays an important role disease progression. The AMP-activated protein kinase (AMPK) related enzyme NUAK1 been identified as potential mediator pathology, whereby NUAK1-mediated Ser356 prevents the degradation proteasome, further...