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University of Trieste
2015-2024
University of Parma
2008
AREA Science Park
1990-2000
Slovak Academy of Sciences
2000
University of Naples Federico II
1985-1988
Istituto di Chimica Biomolecolare
1971-1985
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational Analysis of Regular Enantiomeric SequencesP. De Santis, S. Morosetti, and R. RizzoCite this: Macromolecules 1974, 7, 1, 52–58Publication Date (Print):January 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/ma60037a011https://doi.org/10.1021/ma60037a011research-articleACS PublicationsRequest reuse permissionsArticle Views632Altmetric-Citations193LEARN ABOUT THESE...
It has been previously demonstrated that calcium alginate gels prepared by dialysis often exhibit a concentration inhomogeneity being the polymer considerably lower in center of gel than at edges. Inhomogeneity may be preferred structure microcapsules due to low porosity and higher stability so it is interesting evaluate gradient spherically symmetrical small beads (1.0-0.7 mm diameter) obtained different conditions. In this paper, two complementary techniques have used investigate aspect....
Extracellular polysaccharides are crucial components for biofilm development. Although Bacillus subtilis is one of the most characterized Gram-positive model system, structure-function its exopolysaccharide, EpsA-O, remains to be elucidated. By combining chemical analysis, NMR spectroscopy, rheology, and molecular modeling, high-resolution data EpsA-O structure from atom supramolecular scale was obtained. The repeating unit composed trisaccharide backbone...
The Burkholderia cepacia Complex assembles at least eighteen closely related species that are ubiquitous in nature. Some isolates show beneficial potential for biocontrol, bioremediation and plant growth promotion. On the contrary, other strains pathogens plants immunocompromised individuals, like cystic fibrosis patients. In these subjects, they can cause respiratory tract infections sometimes characterised by fatal outcome. Most of mucoid when grown on a mannitol rich medium also form...
Abstract Antimicrobial peptides (AMPs) are secreted in the airway and contribute to initial defence against inhaled pathogens. Infections of respiratory tract a major cause morbidity mortality preterm newborns patients with cystic fibrosis (CF). In this latter group, state chronic lung infection is due ability bacteria grow as mucoid biofilm, condition characterised by overproduction release polysaccharides (PSs). study, we investigate effect PSs produced pathogens such Pseudomonas...
The interaction of bacterial exopolysaccharides, produced by opportunistic lung pathogens, with antimicrobial peptides the innate primate immune system was investigated. exopolysaccharides were Pseudomonas aeruginosa, Inquilinus limosus and clinical isolates Burkholderia cepacia complex, bacteria that are all involved in infections cystic fibrosis patients. effects biological activities three orthologous cathelicidins from Homo sapiens sapiens, Pongo pygmaeus (orangutan) Presbitys obscurus...
The human cathelicidin peptide LL-37 is an important effector of our innate immune system and contributes to host defence with direct antimicrobial activity immunomodulatory properties, by stimulating wound healing. Its sequence has evolved confer specific structural characteristics that strongly affect these biological activities, differentiate it from orthologues other primate species. In the present paper we report a detailed study folding self-assembly this in comparison rhesus monkey...
Burkholderia cepacia, a Gram-negative bacterium ubiquitous in the environment, is plant pathogen causing soft rot of onions. This microorganism has recently emerged as life-threatening multiresistant cystic fibrosis patients. An important virulence factor B. cepacia lipopolysaccharide (LPS) fraction. Clinical isolates and environmental strains possess LPS high inflammatory nature, which induces level production cytokines. For first time, complete structure lipid A components isolated from...
Fructans isolated from Agave americana grown in South Africa are currently used for spirit production. Structural studies on water-soluble fructans were performed to facilitate the development of other applications including its use as a prebiotic. Acid hydrolysis followed by HPAEC-PAD analysis confirmed that fructan was composed glucose and fructose, size exclusion chromatography indicated saccharides have DP range 6 50. An average 14 estimated (1)H NMR analysis. Linkage ESI-MS suggest A....
Abstract Conformational analysis of DNA–basic polypeptide complexes, based on stereo‐chemical criteria and energy calculations experimental results, is reported. Three types conformations were selected: the distorted β conformation similar to that proposed by Feughelmann et al.; a structure characterized repetition right‐handed left‐handed α helix‐type conformation; an intermediate structure. A model complex between DNA basic polypeptides was proposed, where chain fits narrow groove B form...
Mushrooms represent a formidable source of bioactive compounds. Some these may be considered as biological response modifiers; include compounds with specific function: antibiotics (e.g. plectasin), immune system stimulator (e,g, lentinan), antitumor agents krestin, PSK) and hypolipidemic lovastatin) inter alia. In this study, we focused on the Chinese medicinal mushroom "yun zhi", Trametes versicolor, traditionally used for (cit.) "replenish essence qi (vital energy)". Previous studies...
In the last years, outer membrane vesicles have attracted a lot of attention for development vaccines against bacterial pathogens. Extracellular can be obtained in high yields by genetic mutations, resulting generalized modules antigens (GMMA). Methods to check quality, consistency production, and stability GMMA are fundamental importance. this context, analytical methods size distribution determination verifying integrity possible aggregation particles strongly needed. Herein, particle has...