A5018493762- Lipid metabolism and biosynthesis
- RNA Research and Splicing
- Gout, Hyperuricemia, Uric Acid
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Case Reports on Hematomas
- Adipose Tissue and Metabolism
Indiana University – Purdue University Indianapolis
2023-2024
Indiana University School of Medicine
2023
Indianapolis Zoo
2023
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte LD accumulation implicated in metabolic disorder-associated heart diseases. Here we identify a human long non-coding RNA, Lipid-Droplet Transporter (LIPTER), essential transport cardiomyocytes. LIPTER binds phosphatidic acid and phosphatidylinositol 4-phosphate on surface membranes the MYH10 protein, connecting LDs to MYH10-ACTIN cytoskeleton facilitating transport. deficiencies impair trafficking,...
Abstract Hyperuricemia closely correlates with the development of atherosclerosis, but little is known mechanism by which atherosclerosis progression occurs in hyperuricemia. Atherosclerosis appears to involve pyroptosis, an emerging proinflammatory regulated cell death. This study tested hypothesis that pyroptosis underlies relationship between hyperuricemia and using ApoE −/− mice (a model atherosclerosis), human umbilical vein endothelial cells (HUVECs), atherosclerotic arterial samples....
Background: Recently, long non-coding RNAs (lncRNAs) have emerged as novel human-specific (i.e. non-conserved) regulators of cardiovascular development and disease, which possess diverse functions through interacting with other molecules, including DNA, RNA, protein, lipid. We identified a human lncRNA, LIPTER, mediates lipid droplet (LD) transport to regulate metabilism cardiomyocytes (CMs). Mechanistically, LIPTER binds phospholipids PA PI4P on the LD membranes MYH10 connecting LDs...
Background: Lipid droplets (LDs) are cellular organelles critical for maintaining lipid homeostasis. LD accumulation is associated with cardiomyopathies and heart failure in hyperlipidemia-related metabolic disorders. Currently, the cardiomyocyte (CM) intrinsic mechanism governing transport remains poorly understood. Hypothesis: We hypothesize that long non-coding RNA (lncRNA) can directly participate human CMs. Goals: To reveal a lncRNA LIPTER -mediated droplet system CMs define its role...