A5083576555- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Legume Nitrogen Fixing Symbiosis
- MicroRNA in disease regulation
- Rice Cultivation and Yield Improvement
- Autophagy in Disease and Therapy
- Crop Yield and Soil Fertility
- Pancreatic function and diabetes
- High voltage insulation and dielectric phenomena
- Vacuum and Plasma Arcs
- Plant nutrient uptake and metabolism
- COVID-19 Clinical Research Studies
- Seed Germination and Physiology
- Plasma Diagnostics and Applications
- Hepatitis C virus research
- Environmental and Agricultural Sciences
- Mycotoxins in Agriculture and Food
- Advanced MRI Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Plant Micronutrient Interactions and Effects
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Power Line Inspection Robots
Xinjiang Agricultural University
2024-2025
Third Hospital of Hebei Medical University
2024
Hebei Medical University
2024
Zhejiang University
2019-2024
Hangzhou Normal University
2024
Heilongjiang Bayi Agricultural University
2023-2024
Huazhong Agricultural University
2011-2023
Wannan Medical College
2023
Shanxi University of Traditional Chinese Medicine
2023
First Affiliated Hospital of Wannan Medical College
2023
Abstract Background Pancreatic cancer is one of the most aggressive cancers, and aggressiveness pancreatic in part due to its intrinsic extrinsic drug resistance characteristics, which are also associated with acquisition epithelial-to-mesenchymal transition (EMT). Increasing evidence suggests that EMT-type cells share many biological characteristics stem-like cells. And miR-200 has been identified as a powerful regulator EMT. Methods Cancer Stem Cells (CSCs) human cell line PANC-1 were...
Type 1 diabetes is an autoimmune disease which due to the lack of β cells. The ideal therapy cure pancreas transplantation, but its application confined a limited number people shortage organ and need for life-long immunosuppression. Regenerative medicine methods such as tissue engineered seem provide useful method. In order construct microenvironment similar native that suitable not only cell growth also cellular function exertion, decellularized mouse was used natural 3D scaffold in this...
The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem (iPSCs) in vitro is very important the phylogenetics pancreatic islets, molecular pathogenesis diabetes, and acquisition high-quality β-cells derived for cell therapy. miPSCs were IPCs differentiation. miRNA microarray assays performed by using total RNA our iPCs-derived containing undifferentiated iPSCs iPSCs-derived IPCSs at day 4, 14, 21 during step 3 to screen differentially expressed...
Abstract Due to externalities and market failure, innovation activities are facing insufficient investment. Venture capital guidance funds (VCGFs) an important policy implemented by China's government guide private participate in entrepreneurship activities, it can have impact on scientific technological innovation. Based the panel data of 285 cities China, this paper empirically analyzed VCGFs its mechanism. significantly promote urban role is sustained for three years following VCGF...
Snail-mediated epithelial-mesenchymal transition (EMT) process plays a fundamental role in facilitating pancreatic ductal adenocarcinoma (PDAC) stemness and metastasis.In the present study, we revealed that microRNA-30 (miR-30) members, especially miR-30b, were remarkably downregulated triple-positive (CD24 + , CD44 EpCAM ) cancer stem cells (PCSCs).In addition, miR-30b suppressed EMT PCSCs.Overexpression of led to reduced expression mesenchymal marker N-cadherin upregulation epithelial...
Key to the success of legumes is ability form and maintain optimal symbiotic nodules that enable them balance trade-off between symbiosis plant growth. Cytokinin essential for homeostatic regulation nodulation, but mechanism remains incompletely understood. Here, we show a B-type response regulator GmRR11d mediates systemic inhibition nodulation. induced by rhizobia low level cytokinin, can suppress transcriptional activity GmNSP1 on GmNIN1a inhibit soybean positively regulates cytokinin its...
Iron (Fe) is essential for DNA synthesis, photosynthesis and respiration of plants. The demand Fe substantially increases during legumes-rhizobia symbiotic nitrogen fixation because the synthesis leghemoglobin in host Fe-containing proteins bacteroids. However, mechanism by which plant controls iron transport to nodules remains largely unknown. Here we demonstrate that GmYSL7 serves as a key regulator controlling uptake from root nodule distribution soybean nodules. responsive transports...
Effective pain management is closely related to nurses' knowledge, attitudes and empathy regarding pain. Nursing educators managers should understand the relationship between level, take targeted measures accordingly. Currently, there limited study exploring knowledge among nurses in North China.The purpose of this was investigate level empathy, analyze factors influencing explore these two variables.This a quantitative, descriptive-correlation design.The population registered China, sample...
Winter wheat is a vital grain crop in Xinjiang and severe water scarcity this arid region necessitates efficient irrigation strategies for sustainable production. A two-year field experiment (2022-2023) northern was conducted to evaluate the effects of sowing patterns drip levels on winter growth yield. Two were tested: uniform row spacing (CK1, 15 cm) wide-narrow spacing, comprising 13.3 cm + 20 (M1), 10 30 (M2), (M3). Four applied: 4500 mm2/hm2 CK), 3600 m³/hm² (D1), 2700 (D2), 0 m2/hm2...
Pancreas transplantation is considered as a promising therapeutic option with the potential to cure diabetes. However, efficacy of current clinical limited by donor organ. With regard creating functional pancreas-tissue equivalent for transplantation, vascularization remains large obstacle. To enhance angiogenic properties pancreatic decellularized scaffold, surface modification vasculature was used promote endothelialization efficiency. In this study, an endothelialized scaffold obtained...
The cutting-edge technology of three-dimensional liver decellularized bioscaffold has a potential to provide microenvironment that is suitable for the resident cells and even develop new functional organ. Liver preserved native extracellular matrix architecture in support cell culture. goal this study was discover if derived from mouse could facilitate growth maintenance physiological functions isolated islets. We generated whole organ which successfully preserve proteins vascular channels...
Unintentional injury is the leading cause of childhood death and disability in many countries worldwide. This study aimed to quantify rates risk factors for unintentional areas rural China, where children are left behind by migrant worker parents. We administered a questionnaire aged 9 15, 56 schools five counties Zhejiang Guizhou provinces. Of 3791 respondents, 44% lived with both parents, 23% one parent, 33% neither. Around half (47.9%) had suffered at least past year, burns (26%), animal...
Abstract Background Abscisic acid (ABA) plays an important role in plant growth and adaptation through the ABA signaling pathway. The ABA-responsive element binding (AREB/ABF) family transcriptional factors are central regulators that integrate with various pathways. It has long been known inhibits rhizobial infection nodule formation legumes, but underlying molecular mechanisms remain elusive. Results Here, we show nodulation is very sensitive to exogenous dramatically soybean. In addition,...
Nitrogen (N) is an essential macronutrient for plant growth and productivity. Leguminous plants establish symbiotic relationships with nitrogen-fixing rhizobial bacteria to use atmospheric dinitrogen gas meet high N demand under low-N conditions. Nodule formation fixation are energy-consuming processes inhibited by nitrate present in the environment. Previous studies model leguminous characterized NIN-LIKE PROTEIN (NLP) proteins that mediate control of root nodule symbiosis, but mechanism...
Although there are available therapies as surgery, chemotherapy and radiation, glioblastoma (GBM) still has been considered the most common overwhelming primary tumor of brain. In GBM, brain glioma stem cells (BGSCs) were identified played a crucial role in resistance GBM to conventional described above. PAX3 was previously by our group diagnostic/prognostic marker therapeutic regulator therapy GBM. Here, we hypothesized PAX3/p53 axis promoted process differentiation, regulating cancer cell...