A5056620205- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Algal biology and biofuel production
- Axon Guidance and Neuronal Signaling
Albert Einstein College of Medicine
2017-2019
Neurons receive excitatory or sensory inputs through their dendrites, which often branch extensively to form unique neuron-specific structures. How neurons regulate the formation of particular arbor is only partially understood. In genetic screens using multidendritic PVD somatosensory in nematode Caenorhabditis elegans, we identified a mutation ER stress sensor IRE-1/Ire1 (inositol requiring enzyme 1) as crucial for proper dendrite arborization vivo. We further found that regulation growth...
The extracellular matrix is essential for various aspects of nervous system patterning. For example, sensory dendrites in flies, worms and fish have been shown to rely on coordinated interactions tissues with proteins. Here we show that the conserved basement membrane protein UNC-52/Perlecan required establishing correct number highly ordered dendritic trees somatosensory neuron PVD Caenorhabditis elegans This function dependent four specific immunoglobulin domains, but independent known...