A5081458605- Functional Brain Connectivity Studies
- Neonatal Respiratory Health Research
- Eating Disorders and Behaviors
- Neural and Behavioral Psychology Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Birth, Development, and Health
- Mental Health Research Topics
- Infant Nutrition and Health
- Advanced MRI Techniques and Applications
- Suicide and Self-Harm Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- HER2/EGFR in Cancer Research
- Transcranial Magnetic Stimulation Studies
- Smoking Behavior and Cessation
- Child and Adolescent Psychosocial and Emotional Development
- Lymphoma Diagnosis and Treatment
- Attention Deficit Hyperactivity Disorder
- Neuroscience of respiration and sleep
- Obesity, Physical Activity, Diet
- Breast Cancer Treatment Studies
- Musculoskeletal pain and rehabilitation
- Heart Rate Variability and Autonomic Control
- Advanced Neuroimaging Techniques and Applications
- Neonatal and fetal brain pathology
Laureate Institute for Brain Research
2017-2025
Children's Mercy Hospital
2019-2025
University of Missouri–Kansas City
2020-2025
Mercy Hospital
2019-2025
University of Tulsa
2018-2025
Mercy Research
2022-2025
University of Oklahoma
2025
Oklahoma State University Center for Health Sciences
2025
Saint Francis Health System
2024
Center for Clinical Research (United States)
2024
Several imaging modalities, including T1-weighted structural imaging, diffusion tensor and functional MRI can show chronological age related changes. Employing machine learning algorithms, an individual's data predict their with reasonable accuracy. While details vary according to modality, the general strategy is to: 1) extract image-related features, 2) build a model on training set that uses those features age, 3) validate test dataset, producing predicted for each individual, 4) define...
Abstract Summary Feature selection can improve the accuracy of machine-learning models, but appropriate steps must be taken to avoid overfitting. Nested cross-validation (nCV) is a common approach that chooses classification model and features represent given outer fold based on give maximum inner-fold accuracy. Differential privacy related technique overfitting uses privacy-preserving noise mechanism identify are stable between training holdout sets. We develop consensus nested (cnCV)...
Abstract Introduction Human models of noninvasive breast tumors are limited, and the existing in vivo do not mimic inter- intratumoral heterogeneity. Ductal carcinoma situ (DCIS) is most common type (80%) lesions. The aim this study was to develop an model whereby natural progression human DCIS might be reproduced studied. To accomplish goal, intraductal human-in-mouse (HIM) transplantation developed. resulting models, which mimicked some diversity cancers , were used show whether subtypes...
The brain age gap estimate (BrainAGE) is the difference between estimated and individual chronological age. BrainAGE was studied primarily using MRI techniques. EEG signals in combination with machine learning (ML) approaches were not commonly used for human prediction, BrainAGE. We investigated whether age-related changes are affecting signals, we can predict obtain estimates a rigorous ML framework novel extensive features extraction.
Specific neurochemicals measured with proton magnetic resonance spectroscopy ((1)H-MRS) may serve as biomarkers of pathological mechanism in the brain. We used high field vivo (1)H-MRS to measure a detailed neurochemical profile after experimental traumatic brain injury (TBI) rats. characterized changes contused cortex and normal-appearing perilesional hippocampus over time course from 1 hour 2 weeks injury. found significant 19 out 20 cortex, 9 hippocampus. These provide evidence altered...
Although neuroscience has made tremendous progress towards understanding the basic neural circuitry underlying important processes such as attention, memory and emotion, little been in applying these insights to psychiatric populations make clinically meaningful treatment predictions. The overall aim of Tulsa 1000 (T-1000) study is use NIMH Research Domain Criteria framework order establish a robust reliable dimensional set variables that quantifies positive negative valence, cognition...
BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic created high levels of psychological distress and may have increased suicide risk. METHODS We used the 4-item Ask Suicide-Screening Questions (ASQ) to assess risk among all patients 12 24 years age at a children’s hospital. compared demographics, encounter type (telehealth or face-to-face [F2F]), screening results from April June 2020 (T2) those (T1). RESULTS Fewer were seen T2 than T1 (17 986 vs 863). A greater proportion visits by...
Despite substantial evidence of maternal and infant benefits breastfeeding, adolescent mothers initiate breastfeeding less often maintain for shorter durations when compared to their adult counterparts. A randomized controlled trial drawing on the theory planned behavior developmental was conducted determine if an education counseling intervention provided by a lactation consultant—peer counselor team increased initiation duration up 6 months postpartum among mothers. Study participants ( N...
CXCL1 is a chemotactic cytokine shown to regulate breast cancer progression and chemo-resistance. However, the prognostic significance of expression in has not been fully characterized. Fibroblasts are important cellular components tumor microenvironment, recent studies indicate that this cell type potential source tumors. The goal study was further characterize patterns stroma, determine stromal expression, identify factors affecting expression. Stromal protein analyzed 54 normal 83...
Background One in three college students experience significant depression or anxiety interfering with daily functioning. Resilience programs that can be administered to all offer an opportunity for addressing this public health problem. The current study objective was assess the benefit of a brief, universal resilience program first-year students. Method First-year at private, midwestern university participated. This trial used pragmatic design, delivering intervention within...
Floatation-REST (Reduced Environmental Stimulation Therapy), an intervention that attenuates exteroceptive sensory input to the nervous system, has recently been found reduce state anxiety across a diverse clinical sample with high levels of sensitivity (AS). To further examine this anxiolytic effect, present study investigated affective and physiological changes induced by assessed whether individuals AS experienced any alterations in their awareness for interoceptive sensation while...
OBJECTIVE: To examine the potential of dextrose injection versus lidocaine supervised usual care to reduce sport alteration and sport-related symptoms in adolescent athletes with Osgood-Schlatter disease. PATIENTS AND METHODS: Girls aged 9 15 boys 10 17 were randomly assigned either therapist-supervised or double-blind 1% solution without 12.5% dextrose. Injections administered monthly for 3 months. All subjects then offered injections as needed. Unaltered (Nirschl Pain Phase Scale <...
Although Francisella tularensis subsp. is known to cause extensive tissue necrosis, the pathogenesis of injury has not been elucidated. To characterize cell death in tularemia, C57BL/6 mice were challenged by intranasal route with type A F. tularensis, and pathological changes infected tissues characterized over next 4 days. At 3 days postinfection, well-organized inflammatory infiltrates developed spleen liver following spread infection from lungs. By day, death, presence pyknotic cells...
Purpose Our previous research found lower fetal HR and increased variability (HRV) in women who exercised during pregnancy. This finding is similar to the adult heart training response at rest due aerobic exercise. Dose–response associations have been between physical activity cardiorespiratory fitness adults. Therefore, our objective was determine whether there a dose–response relationship maternal HR, HRV, sympathovagal balance. Methods Pregnant completed questionnaire magnetocardiogram...
J. Neurochem. (2012) 121 , 407–417. Abstract Chronic hyperglycemia could lead to cerebral metabolic alterations and CNS injury. However, findings of in poorly managed diabetes humans animal models are rather inconsistent. We have characterized the consequences untreated from onset chronic stage a streptozotocin‐induced rat model diabetes. In vivo 1 H magnetic resonance spectroscopy was used measure over 20 neurochemicals longitudinally. Upon (acute state), increases brain glucose levels were...
Floatation-REST (Reduced Environmental Stimulation Therapy) reduces sensory input to the nervous system through act of floating supine in a pool water saturated with Epsom salt. The float experience is calibrated so that signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational and proprioceptive channels are minimized, as most movement speech. This open-label study aimed examine whether would attenuate symptoms anxiety, stress, depression clinical...
Abstract Objective The coronavirus disease 2019 pandemic (COVID-19) may increase pediatric mental health needs due to its social, economic, and public threats, especially among Black, Indigenous, People of Color those served within disadvantaged communities. COVID-19 protocols have resulted in increased provision telehealth integrated primary care (IPC) but little is known about IPC utilization during the for diverse traditionally underserved groups. Methods A comparative study was conducted...
We explored whether maternal exercise during pregnancy moderates the effect of fetal breathing movements on cardiac autonomic control assessed by metrics heart rate (HR) and variability (HRV). Thirty women were assigned to Exercise or Control group (n=15/group) based modifiable physical activity questionnaire (MPAQ). Magnetocardiograms (MCG) recorded using a dedicated biomagnetometer. Periods apnea identified diaphragmatic magnetomyogram (dMMG) as marker. MCG R-waves marked. Metrics HR HRV...
There are an estimated 60,000 new cases of ductal carcinoma in situ (DCIS) each year. A lack understanding DCIS pathobiology has led to overtreatment more than half patients. We profiled the temporal molecular changes during transition invasive (IDC) using vivo progression models. These studies identified B cell lymphoma-9 (BCL9) as a potential driver early invasion. BCL9 is newly found co-activator Wnt-stimulated β-catenin-mediated transcription. been shown promote multiple myeloma and...