A5090015458- Autoimmune and Inflammatory Disorders Research
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Emergency and Acute Care Studies
- Neurotransmitter Receptor Influence on Behavior
- Pediatric Pain Management Techniques
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Homelessness and Social Issues
- Traffic and Road Safety
- Intramuscular injections and effects
- Treatment of Major Depression
- Gender Roles and Identity Studies
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Global Public Health Policies and Epidemiology
- Sexuality, Behavior, and Technology
- Neuroendocrine regulation and behavior
- COVID-19 and healthcare impacts
- Pharmaceutical studies and practices
- Environmental and Social Impact Assessments
- Telemedicine and Telehealth Implementation
- Healthcare Systems and Technology
- Adolescent and Pediatric Healthcare
Children's Hospital of Eastern Ontario
2022-2025
University of Ottawa
2022-2025
University of Toronto
2014-2022
Public Health Agency of Canada
2022
Centre for Addiction and Mental Health
2022
Western University
2009-2013
The cannabinoid CB1 receptor system is critically involved in the control of associative fear memory formation within amygdala-prefrontal cortical pathway. found high concentrations brain structures that are critical for emotional processing, including basolateral amygdala (BLA) and prelimbic division (PLC) medial prefrontal cortex (mPFC). However, precise role transmission BLA during processing not fully understood. We examined potential an olfactory fear-conditioning procedure rats by...
For adolescents with gender dysphoria, it has become common to be offered hormonal treatment either delay or suppress pubertal development and/or masculinize feminize the body. At same time, been our clinical impression that psychological vulnerability of at least some these youth overlooked. Fifty consecutive referrals a DSM-IV-TR diagnosis identity disorder (GID) constituted sample. Information obtained intake was coded for presence absence 15 psychosocial and factors. The mean number...
The cannabinoid CB1 receptor system is functionally involved in the processing and encoding of emotionally salient sensory information, learning memory. found high concentrations brain structures that are critical for emotional processing, including basolateral amygdala (BLA) medial prefrontal cortex (mPFC). In addition, synaptic plasticity form long-term potentiation (LTP) within BLA > mPFC pathway an established correlate exposure to events. We performed a series vivo LTP studies by...
The medial prefrontal cortex (mPFC) plays a significant role in associative learning and memory formation during the opiate addiction process. Various lines of evidence demonstrate that glutamatergic (GLUT) transmission through N-methyl D-aspartate (NMDA) receptor can modulate neuronal network activity within mPFC influence dopaminergic signaling mesocorticolimbic pathway. However, little is known about how modulation NMDA may regulate reward formation. Using conditioned place preference...
Abstract Objectives Virtual care can facilitate access to pediatric emergency departments (EDs), but it is unclear if virtual equitably accessed by patients from marginalized communities. This study compares the use of a ED between neighbourhoods with different levels marginalization. Methods cross-sectional visits per neighbourhood (defined census dissemination area) within 100 km tertiary-care hospital in Ottawa, Ontario, May December 2020. Our primary outcome was incidence rate ratios...
The consolidation of newly acquired memories involves the temporal transition from a recent, less stable trace to more permanent consolidated form. Opiates possess potent rewarding effects and produce powerful associative memories. activation these is associated with opiate abuse relapse phenomena persistence compulsive dependence. However, neuronal, molecular mechanisms by which reward are not currently understood. We report that switch between basolateral nucleus amygdala (BLA) (early...
Despite the widespread use of subcutaneous methotrexate in treating pediatric rheumatic disorders, amount pain associated with injections has not been quantified. Our study aims 1) to quantify methotrexate, 2) explore predictors pain, 3) determine frequency patient-reported clinical adverse effects and 4) identify coping strategies patients caregivers. Patients aged 4–17 years rheumatologic diseases who were receiving weekly for at least 4 weeks invited participate this prospective cohort...
<h3>Background:</h3> Cannabis-related emergency department visits can be an entry point for youths to mental health and substance use care systems. We aimed examine trends in cannabis-related as a function of youths' age sex. <h3>Methods:</h3> Using administrative data, we examined all departments Ontario, Canada, from 2003 2017, by youth aged 10–24 years (grouped 10–13, 14–18 19–24 yr) determine visits. were identified using <i>International Statistical Classification Diseases Related...
Background/Purpose: Methotrexate is frequently used to treat a variety of paediatric rheumatologic conditions. We explored patient‐reported frequency side effects and coping strategies for weekly injections subcutaneous methotrexate. Methods: A prospective observational cohort study was conducted from June 2013 through August 2013. All patients with clinic appointments in rheumatology during this period were screened eligibility. Patients aged 4–17 years who currently receiving methotrexate...
The Infrastructure Investment and Jobs Act (Public Law 117-58) has ambitious intentions beyond roads bridges including climate change mitigation adaptation environmental justice. As these projects are launched health equity impacts should be evaluated. There 14 documented pathways that connect transportation to health. Health Impact Assessment (HIA) can a valuable tool in infrastructure planning ensure project benefits maximized harms minimized; but the practice of HIA with respect coverage...
Background/Purpose: Procedural pain may have long-term negative effects on children. The aim of this study was to evaluate the amount associated with weekly subcutaneous injections methotrexate. Methods: A prospective observational cohort conducted from June 2013 through August 2013. All patients appointments in rheumatology clinic during period were screened for eligibility. Patients between ages 4\N17 years who currently receiving methotrexate at least 4 weeks invited...