A5040658701- Skin and Cellular Biology Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Psoriasis: Treatment and Pathogenesis
- Biomedical Text Mining and Ontologies
- Genomics and Rare Diseases
- RNA regulation and disease
- Immunotherapy and Immune Responses
- Pluripotent Stem Cells Research
- Wnt/β-catenin signaling in development and cancer
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Translation Studies and Practices
- Asthma and respiratory diseases
- Computational Drug Discovery Methods
- Viral Infectious Diseases and Gene Expression in Insects
- Fibroblast Growth Factor Research
- Cell Image Analysis Techniques
- Dermatological and Skeletal Disorders
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Mesenchymal stem cell research
- Skin Protection and Aging
- Topic Modeling
- Metabolomics and Mass Spectrometry Studies
Centre for Biomedical Network Research on Rare Diseases
2014-2025
Hospital Universitario Fundación Jiménez Díaz
2014-2025
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2014-2025
Universidad Carlos III de Madrid
2016-2025
Universidad Complutense de Madrid
2020-2025
Instituto de Salud Carlos III
2014-2023
3M (United States)
2011
Regenerative Medicine Institute
2011
Center of Regenerative Medicine in Barcelona
2011
Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer‐prone genodermatoses whose causal genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. Recent evidence highlights role stromal microenvironment in pathology these disorders. To investigate, by means comparative gene expression analysis, played dermal fibroblasts pathogenesis RDEB, KS XPC. We...
Drug repositioning is a strategy to identify new uses for existing, approved, or research drugs that are outside the scope of its original medical indication. repurposing based on fact one drug can act multiple targets two diseases have molecular similarities, among others. Currently, thanks rapid advancement high-performance technologies, massive amount biological and biomedical data being generated. This allows use computational methods models networks develop possibilities repurposing....
The quest for youthful, healthy skin and full, vibrant hair has long been a driving force in the dermocosmetics field. However, traditional approaches often struggle to address underlying causes of aging, damage, loss. Regenerative cosmetics powered by tissue engineering offer transformative alternative. This review explores emerging field using engineered tissues cosmetic purposes, focusing specifically on their potential anti-aging, repair, restoration applications. We discuss how these...
Drug discovery and development remains a complex time-consuming process, often hindered by high costs low success rates. In the big data era, artificial intelligence (AI) has emerged as promising tool to accelerate optimize these processes, particularly in field of oncology. This review explores application AI-based methods for drug repurposing natural product-inspired design cancer, focusing on their potential address challenges limitations traditional approaches. We delve into various...
Kindler Syndrome (KS) is a rare genodermatosis characterized by skin fragility, atrophy, premature aging and poikiloderma. It caused mutations in the FERMT1 gene, which encodes kindlin-1, protein involved integrin signalling formation of focal adhesions. Several reports have shown presence non-melanoma cancers KS patients but systematic study evaluating risk these tumors at different ages their potential outcome has not yet been published. We here addressed this condition retrospective 91...
Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) is an autosomal recessive disorder caused by pathogenic variants in PLEC1, which encodes plectin. It characterized mild mucocutaneous fragility and blistering muscle weakness. Translational readthrough-inducing drugs, such as repurposed aminoglycoside antibiotics, may represent a valuable therapeutic alternative for untreatable rare diseases nonsense variants.To evaluate whether systemic gentamicin, at dose of 7.5 mg/kg/d 14...
Kindler Syndrome (KS) is an autosomal recessive skin disorder characterized by blistering, photosensitivity, premature aging, and propensity to cancer. In spite of the knowledge underlying cause this disease involving mutations FERMT1 (fermitin family member 1), efforts characterize genotype-phenotype correlations, clinical variability genodermatosis still poorly understood. addition, several pathognomonic features KS, not related fragility such as inflammation cancer predisposition have...
Rare diseases affect a small number of people compared to the general population. However, more than 6,000 different rare exist and, in total, they 300 million worldwide. share as part their main problem, delay diagnosis and sparse information available for researchers, clinicians, patients. Finding diagnostic can be very long frustrating experience patients families. The average is between 6-8 years. Many these result manifestations among patients, which hampers even detection correct...
Although rare diseases are characterized by low prevalence, approximately 400 million people affected a disease. The early and accurate diagnosis of these conditions is major challenge for general practitioners, who do not have enough knowledge to identify them. In addition this, usually show wide variety manifestations, which might make the even more difficult. A delayed can negatively affect patient's life. Therefore, there an urgent need increase scientific medical about diseases. Natural...
The quest for youthful, healthy skin and full, vibrant hair has long been a driving force in the dermocosmetics field. However, traditional approaches often struggle to address underlying causes of aging, damage, loss. Regenerative cosmetics, powered by tissue engineering, offer transformative alternative. This review explores emerging field using engineered tissues cosmetic purposes, focusing specifically on their potential anti-aging, repair, restoration applications. We discuss how these...
The role of stroma is fundamental in the development and behavior epithelial tumors. In this regard, limited growth squamous cell carcinomas (SCC) or cell-lines derived from them has been achieved immunodeficient mice. Moreover, lack faithful recapitulation original human neoplasia complexity often observed xenografted Here, we used tissue engineering techniques to recreate a humanized tumor for SCCs grafted host mice, by combining CAF (cancer associated fibroblasts)-like cells with...
We present a novel method to assess the variations in protein expression and spatial heterogeneity of tumor biopsies with application computational pathology. This was done using different antigen stains for each tissue section proceeding complex image registration followed by final step color segmentation detect exact location proteins interest. For proper assessment, needs be highly accurate careful study patterns. However, histopathological images comes three main problems: high amount...