A5050765428- PI3K/AKT/mTOR signaling in cancer
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Synthesis and biological activity
- Carcinogens and Genotoxicity Assessment
- Angiogenesis and VEGF in Cancer
- Growth Hormone and Insulin-like Growth Factors
- Synthesis and Biological Evaluation
- Cholesterol and Lipid Metabolism
- Click Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Bone Tissue Engineering Materials
- Sphingolipid Metabolism and Signaling
- Protein Tyrosine Phosphatases
- Phytoestrogen effects and research
- Multicomponent Synthesis of Heterocycles
- Bone Metabolism and Diseases
- Nanomaterials for catalytic reactions
- Glutathione Transferases and Polymorphisms
- Cancer therapeutics and mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Drug Transport and Resistance Mechanisms
Nicholls State University
2019-2024
Xavier University of Louisiana
2017-2018
University of New Orleans
2014
Background: Members of the cytochrome P450 1A family metabolize many procarcinogens such as polycyclicaromatic hydrocarbons and heterocyclic amines. Inactivation these enzymes is a prerequisite for cancer prevention treatment in certain cases. Mechanism-based inhibition (time co-factor dependent) an effective method inactivation enzymes. Our recent study on emodin analogs revealed anthraquinone with ortho-methylarylamine moiety that exhibited timedependent 1A1 1A2. Keywords: Carbazoles,...
Abstract The backbone of 2‐hydroxyisophthalic acid was identified as a potential metal oxide anchor because the perfect alignment all three its donor groups for binding to inorganic surfaces. It can therefore be used in design organic linkers based hybrid materials. Optimized and scalable methods synthesis ( 1 ) 5‐substituted derivatives: 5‐bromo‐ 2 ), 5‐sulfooxy‐ 3 5‐hydroxy‐ 4 5‐PEG600 5 are presented. Dynamic light scattering (DLS) demonstrated that compound inhibits Fe(OH) precipitation...
Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to targeting this pathway is a frequent occurrence. Therapeutics p70S6K1, downstream member pathway, have recently gained importance due its critical role in all types and status as prognostic marker. We developed new class p70S6K1 inhibitors that show growth inhibition MCF7 cells.
Human epidermal growth factor receptor 2 (HER2) is overexpressed in nearly 20–30% of breast cancers and associated with metastasis resulting poor patient survival high recurrence. The dual EGFR/HER2 kinase inhibitor lapatinib has shown promising clinical results, but its limitations have also led to the resistance activation tumor pathways. Following our previous investigation quinones as HER2 inhibitors, we synthesized several naphthoquinone derivatives that significantly inhibited cells...
Abstract The 40S ribosomal S6 kinase 1 (S6K1), a conserved serine/threonine protein kinase, is the principal effector downstream of PI3K/mTOR regulatory signaling pathway. Over-expression RPS6K1 has been associated with cell transformation and elevated proliferation rates in tumors, poor prognosis an increased risk local recurrence. found to play important role progression ER-positive breast cancer, HER2 positive cancer node-negative premenopausal cancer. Overexpression closely correlated...
Abstract Currently, more than 3.8 million women in the United States are diagnosed with breast cancer which is second leading cause of cancer-related death women. The correlation ribosomal protein S6 kinase 1 (S6K1) activity and evident from amplification S6K1 localized chromosomal region 17q23 20% primary cancers. a conserved serine/threonine kinase, principal effector downstream PI3K/mTOR regulatory signaling pathway. Over-expression has been associated cell transformation elevated...