A5039898916- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Trace Elements in Health
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- interferon and immune responses
- Genetics and Neurodevelopmental Disorders
- S100 Proteins and Annexins
- Muscle Physiology and Disorders
- Signaling Pathways in Disease
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects and Toxicity Studies
- Heavy Metal Exposure and Toxicity
Florey Institute of Neuroscience and Mental Health
2021-2024
The University of Melbourne
2018-2023
Abstract The identification of factors that regulate myelination provides important insight into the molecular mechanisms coordinate nervous system development and myelin regeneration after injury. In this study, we investigated role amyloid precursor protein (APP) its paralogue precursor‐like 2 (APLP2) in using APP APLP2 knockout (KO) mice. Given BACE1 regulates sheath thickness both peripheral central systems, sought to determine if APLP2, as alternate substrates, also modulate...
Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity in young adults. The role iron potentiating neurodegeneration following TBI has gained recent interest as deposition been detected the injured weeks to months post-TBI, both preclinical clinical setting. A failure homeostasis can lead oxidative stress, inflammation excitotoxicity; whether this is or consequence long-term effects unknown.We investigated effect therapeutic intervention using brain-permeable...
Repetitive mild traumatic brain injury (r-mTBI) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many which are characterised by tau pathology, metal dyshomeostasis and behavioural impairments. We aimed to characterise status involvement iron in repetitive controlled cortical impact (5 impacts, 48 h apart) 3-month-old C57Bl6 mice at chronic (12-month) time point. performed battery tests, neurodegeneration-associated proteins (tau...
Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. The amyloid precursor protein (APP) highly expressed in the central nervous system has been shown to modulate outcomes MND. APP part gene family that includes precursor-like 1 (APLP1) 2 (APLP2) genes. In present study, we investigated role APLP2 MND through examination human spinal cord tissue crossing knockout mice with superoxide dismutase...
Background and Purpose: Traumatic brain injury (TBI) remains a leading cause of mortality morbidity in young adults. The role iron potentiating neurodegeneration following TBI has gained recent interest since deposition been detected the injured weeks to months post-TBI, both preclinical clinical setting. A failure homeostasis can lead oxidative stress, inflammation excitotoxicity; whether this is or consequence long-term effects unknown. Experimental approach: We investigated iron, effect...
Abstract Introduction: Motor neurone disease (MND) is a neurodegenerative disorder characterised by progressive destruction of motor neurons, muscle paralysis and death. The amyloid precursor protein (APP) highly expressed in the central nervous system has been shown to modulate outcomes MND. APP part gene family that includes precursor-like 1 (APLP1) 2 (APLP2) genes. Methods In present study, we investigated role APLP2 MND through examination human spinal cord tissue crossing knockout mice...